ID   CAH3_BOVIN              Reviewed;         260 AA.
AC   Q3SZX4;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Carbonic anhydrase 3;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonic anhydrase III;
DE            Short=CA-III;
DE   AltName: Full=Carbonate dehydratase III;
GN   Name=CA3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reversible hydration of carbon dioxide (By similarity).
CC   -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
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DR   EMBL; BC102666; AAI02667.1; -; mRNA.
DR   IPI; IPI00712036; -.
DR   RefSeq; NP_001029609.1; -.
DR   UniGene; Bt.49056; -.
DR   SMR; Q3SZX4; 2-260.
DR   Ensembl; ENSBTAG00000015214; Bos taurus.
DR   GeneID; 513212; -.
DR   KEGG; bta:513212; -.
DR   HOVERGEN; Q3SZX4; -.
DR   OMA; Q3SZX4; LPWSASY.
DR   BRENDA; 4.2.1.1; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro.
DR   InterPro; IPR001148; Carbonic_anhydrase_a-class_cat.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   InterPro; IPR018441; Carbonic_anhydrase_CA3.
DR   Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1.
DR   PANTHER; PTHR18952:SF29; Carbonic_anhydrase_CA3; 1.
DR   PANTHER; PTHR18952; Euk_COanhd; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   ProDom; PD000865; Euk_COanhd; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Lyase; Metal-binding; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    260       Carbonic anhydrase 3.
FT                                /FTId=PRO_0000262533.
FT   METAL        94     94       Zinc; catalytic.
FT   METAL        96     96       Zinc; catalytic.
FT   METAL       119    119       Zinc; catalytic.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   260 AA;  29370 MW;  F78A6E7E9C47028B CRC64;
     MAKEWGYADH NGPDHWHELF PNAKGENQSP IELNTKEISH DPSLKPWTAS YDPGSAKTIL
     NNGKTCRVVF DDTYDRSMLR GGPLAAPYRL RQFHLHWGSS DDHGSEHSVD GVKYAAELHL
     VHWNSKYNSY ATALKHADGI AVVGVFLKIG REKGEFQLLL DALDKIKTKG KEAPFNNFNP
     SCLFPACRDY WTYHGSFTTP PCEECIVWLL LKEPITVSSD QIAKLRTLYS SAENEPPVPL
     VRNWRPPQPI KGRIVKASFK
//