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Protein

Carbonic anhydrase 3

Gene

CA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Reversible hydration of carbon dioxide.By similarity

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Zinc; catalyticBy similarity
Metal bindingi96 – 961Zinc; catalyticBy similarity
Metal bindingi119 – 1191Zinc; catalyticBy similarity
Active sitei127 – 1271By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 3 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase III
Carbonic anhydrase III
Short name:
CA-III
Gene namesi
Name:CA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Protein family/group databases

Allergomei10878. Bos d CA.

Chemistry

ChEMBLiCHEMBL2096971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 260259Carbonic anhydrase 3PRO_0000262533Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei50 – 501PhosphoserineBy similarity
Modified residuei55 – 551PhosphoserineBy similarity
Modified residuei73 – 731PhosphothreonineBy similarity
Modified residuei127 – 1271PhosphotyrosineBy similarity
Modified residuei182 – 1821S-glutathionyl cysteineBy similarity
Modified residuei187 – 1871S-glutathionyl cysteineBy similarity
Modified residuei216 – 2161PhosphothreonineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity

Post-translational modificationi

S-glutathionylated in hepatocytes under oxidative stress.By similarity

Keywords - PTMi

Acetylation, Glutathionylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SZX4.
PeptideAtlasiQ3SZX4.
PRIDEiQ3SZX4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015214.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020243.

Chemistry

BindingDBiQ3SZX4.

Structurei

3D structure databases

ProteinModelPortaliQ3SZX4.
SMRiQ3SZX4. Positions 2-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 259257Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 674Involved in proton transferBy similarity
Regioni198 – 1992Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiQ3SZX4.
KOiK01672.
OMAiKQRDGIA.
OrthoDBiEOG091G0XFM.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018441. Carbonic_anhydrase_CA3.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF127. PTHR18952:SF127. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEWGYADH NGPDHWHELF PNAKGENQSP IELNTKEISH DPSLKPWTAS
60 70 80 90 100
YDPGSAKTIL NNGKTCRVVF DDTYDRSMLR GGPLAAPYRL RQFHLHWGSS
110 120 130 140 150
DDHGSEHSVD GVKYAAELHL VHWNSKYNSY ATALKHADGI AVVGVFLKIG
160 170 180 190 200
REKGEFQLLL DALDKIKTKG KEAPFNNFNP SCLFPACRDY WTYHGSFTTP
210 220 230 240 250
PCEECIVWLL LKEPITVSSD QIAKLRTLYS SAENEPPVPL VRNWRPPQPI
260
KGRIVKASFK
Length:260
Mass (Da):29,370
Last modified:January 23, 2007 - v3
Checksum:iF78A6E7E9C47028B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102666 mRNA. Translation: AAI02667.1.
RefSeqiNP_001029609.1. NM_001034437.1.
UniGeneiBt.49056.

Genome annotation databases

EnsembliENSBTAT00000020243; ENSBTAP00000020243; ENSBTAG00000015214.
GeneIDi513212.
KEGGibta:513212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102666 mRNA. Translation: AAI02667.1.
RefSeqiNP_001029609.1. NM_001034437.1.
UniGeneiBt.49056.

3D structure databases

ProteinModelPortaliQ3SZX4.
SMRiQ3SZX4. Positions 2-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020243.

Chemistry

BindingDBiQ3SZX4.
ChEMBLiCHEMBL2096971.

Protein family/group databases

Allergomei10878. Bos d CA.

Proteomic databases

PaxDbiQ3SZX4.
PeptideAtlasiQ3SZX4.
PRIDEiQ3SZX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020243; ENSBTAP00000020243; ENSBTAG00000015214.
GeneIDi513212.
KEGGibta:513212.

Organism-specific databases

CTDi761.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiQ3SZX4.
KOiK01672.
OMAiKQRDGIA.
OrthoDBiEOG091G0XFM.
TreeFamiTF316425.

Enzyme and pathway databases

ReactomeiR-BTA-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

PROiQ3SZX4.

Gene expression databases

BgeeiENSBTAG00000015214.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018441. Carbonic_anhydrase_CA3.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF127. PTHR18952:SF127. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH3_BOVIN
AccessioniPrimary (citable) accession number: Q3SZX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.