Reviewed, UniProtKB/Swiss-Prot Q3SZX4 (CAH3_BOVIN)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 3
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase III
      Short name=CA-III
    Carbonate dehydratase III

Gene names

Name:

CA3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide By similarity.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 260	259	Carbonic anhydrase 3		PRO_0000262533
Sites
	Metal binding	94	1	Zinc; catalytic
	Metal binding	96	1	Zinc; catalytic
	Metal binding	119	1	Zinc; catalytic
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZX4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F78A6E7E9C47028B	FASTA	260	29,370
	10 20 30 40 50 60 MAKEWGYADH NGPDHWHELF PNAKGENQSP IELNTKEISH DPSLKPWTAS YDPGSAKTIL 70 80 90 100 110 120 NNGKTCRVVF DDTYDRSMLR GGPLAAPYRL RQFHLHWGSS DDHGSEHSVD GVKYAAELHL 130 140 150 160 170 180 VHWNSKYNSY ATALKHADGI AVVGVFLKIG REKGEFQLLL DALDKIKTKG KEAPFNNFNP 190 200 210 220 230 240 SCLFPACRDY WTYHGSFTTP PCEECIVWLL LKEPITVSSD QIAKLRTLYS SAENEPPVPL 250 260 VRNWRPPQPI KGRIVKASFK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102666 mRNA. Translation: AAI02667.1.
IPI	IPI00712036.
RefSeq	NP_001029609.1.
UniGene	Bt.49056
3D structure databases
SMR	Q3SZX4. Positions 2-260.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000020243; ENSBTAP00000020243; ENSBTAG00000015214; Bos taurus. [Genome view]
GeneID	513212.
KEGG	bta:513212.
Organism-specific databases
CTD	513212.
Phylogenomic databases
HOVERGEN	Q3SZX4.
OMA	LPWSASY.
Enzyme and pathway databases
BRENDA	4.2.1.1. 251.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018441. Carbonic_anhydrase_CA3. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF29. Carbonic_anhydrase_CA3. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH3_BOVIN

Accession

Primary (citable) accession number: Q3SZX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 34 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)