ID   CDO1_BOVIN              Reviewed;         200 AA.
AC   Q3SZU4;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Cysteine dioxygenase type 1;
DE            EC=1.13.11.20;
DE   AltName: Full=Cysteine dioxygenase type I;
DE            Short=CDO-I;
DE            Short=CDO;
GN   Name=CDO1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-cysteine + O(2) = 3-sulfinoalanine.
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis;
CC       hypotaurine from L-cysteine: step 1/2.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a
CC       structural role through stabilizing the Fe(2+) ion, and prevents
CC       the production of highly damaging free hydroxyl radicals by
CC       holding the oxygen radical via hydroxyl hydrogen (By similarity).
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
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DR   EMBL; BT025474; ABF57430.1; -; mRNA.
DR   EMBL; BC102709; AAI02710.1; -; mRNA.
DR   IPI; IPI00825885; -.
DR   RefSeq; NP_001029637.1; -.
DR   UniGene; Bt.2723; -.
DR   Ensembl; ENSBTAG00000017442; Bos taurus.
DR   GeneID; 514462; -.
DR   KEGG; bta:514462; -.
DR   HOVERGEN; Q3SZU4; -.
DR   BRENDA; 1.13.11.20; 251.
DR   GO; GO:0017172; F:cysteine dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046439; P:L-cysteine metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR010300; Cys_dOase_I.
DR   Pfam; PF05995; CDO_I; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phosphoprotein;
KW   Thioether bond.
FT   CHAIN         1    200       Cysteine dioxygenase type 1.
FT                                /FTId=PRO_0000246081.
FT   METAL        86     86       Iron; catalytic (By similarity).
FT   METAL        88     88       Iron; catalytic (By similarity).
FT   METAL       140    140       Iron; catalytic (By similarity).
FT   MOD_RES      59     59       Phosphothreonine (By similarity).
FT   CROSSLNK     93    157       3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By
FT                                similarity).
SQ   SEQUENCE   200 AA;  23013 MW;  65796B06507CF936 CRC64;
     MERTEVLKPR TLADLIRVLH QLFAGEEINV EEVQAVMEAY ESNPAEWAVY AKFDQYRYTR
     NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKMLQG NLKETLFAWP DKKSNEMIKK
     SERILRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVIMT
     FHSKFGIKTP FTTSGSLENN
//