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Q3SZU4

- CDO1_BOVIN

UniProt

Q3SZU4 - CDO1_BOVIN

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Protein

Cysteine dioxygenase type 1

Gene
CDO1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalytic By similarity
Metal bindingi88 – 881Iron; catalytic By similarity
Metal bindingi140 – 1401Iron; catalytic By similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:CDO1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cysteine dioxygenase type 1PRO_0000246081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Keywords - PTMi

Thioether bond

Proteomic databases

PRIDEiQ3SZU4.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023186.

Structurei

3D structure databases

ProteinModelPortaliQ3SZU4.
SMRiQ3SZU4. Positions 6-190.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG126313.
HOGENOMiHOG000177818.
HOVERGENiHBG004469.
InParanoidiQ3SZU4.
KOiK00456.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SZU4-1 [UniParc]FASTAAdd to Basket

« Hide

MERTEVLKPR TLADLIRVLH QLFAGEEINV EEVQAVMEAY ESNPAEWAVY    50
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKMLQG 100
NLKETLFAWP DKKSNEMIKK SERILRENQC AYINDSIGLH RVENISHTEP 150
AVSLHLYSPP FDTCHAFDQR TGHKNKVIMT FHSKFGIKTP FTTSGSLENN 200
Length:200
Mass (Da):23,013
Last modified:October 11, 2005 - v1
Checksum:i65796B06507CF936
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025474 mRNA. Translation: ABF57430.1.
BC102709 mRNA. Translation: AAI02710.1.
RefSeqiNP_001029637.1. NM_001034465.2.
UniGeneiBt.2723.

Genome annotation databases

GeneIDi514462.
KEGGibta:514462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025474 mRNA. Translation: ABF57430.1 .
BC102709 mRNA. Translation: AAI02710.1 .
RefSeqi NP_001029637.1. NM_001034465.2.
UniGenei Bt.2723.

3D structure databases

ProteinModelPortali Q3SZU4.
SMRi Q3SZU4. Positions 6-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000023186.

Proteomic databases

PRIDEi Q3SZU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 514462.
KEGGi bta:514462.

Organism-specific databases

CTDi 1036.

Phylogenomic databases

eggNOGi NOG126313.
HOGENOMi HOG000177818.
HOVERGENi HBG004469.
InParanoidi Q3SZU4.
KOi K00456.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Miscellaneous databases

NextBioi 20871348.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCDO1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: January 22, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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