Reviewed,
UniProtKB/Swiss-Prot Q3SZU4 (CDO1_BOVIN)
Last modified
September 1, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cysteine dioxygenase type 1 EC=1.13.11.20 Alternative name(s): Cysteine dioxygenase type I Short name=CDO-I Short name=CDO | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 200 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-cysteine + O2 = 3-sulfinoalanine. |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Pathway | Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. |
| Subunit structure | Monomer By similarity. |
| Post-translational modification | The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity. |
| Sequence similarities | Belongs to the cysteine dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Phosphoprotein Thioether bond |
| Gene Ontology (GO) | |
| Biological process | L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 200 | 200 | Cysteine dioxygenase type 1 | PRO_0000246081 | |||||||
Sites | |||||||||||
| Metal binding | 86 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 88 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 140 | 1 | Iron; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 59 | 1 | Phosphothreonine By similarity | ||||||||
| Cross-link | 93 ↔ 157 | 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity | |||||||||
Sequences
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References
| [1] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| BT025474 mRNA. Translation: ABF57430.1. BC102709 mRNA. Translation: AAI02710.1. | |
| IPI | IPI00825885. |
| RefSeq | NP_001029637.1. |
| UniGene | Bt.2723 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3SZU4. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000023186; ENSBTAP00000023186; ENSBTAG00000017442; Bos taurus. [Genome view] |
| GeneID | 514462. |
| KEGG | bta:514462. |
Organism-specific databases | |
| CTD | 514462. |
Phylogenomic databases | |
| HOVERGEN | Q3SZU4. |
Enzyme and pathway databases | |
| BRENDA | 1.13.11.20. 251. |
Family and domain databases | |
| InterPro | IPR010300. Cys_dOase_I. [Graphical view] |
| Pfam | PF05995. CDO_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDO1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3SZU4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


