Reviewed, UniProtKB/Swiss-Prot Q3SZU4 (CDO1_BOVIN)

Names and origin

Protein names

Recommended name:
    Cysteine dioxygenase type 1
    EC=1.13.11.20
Alternative name(s):
    Cysteine dioxygenase type I
      Short name=CDO-I
      Short name=CDO

Gene names

Name:

CDO1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Subunit structure	Monomer By similarity.
Post-translational modification	The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Phosphoprotein Thioether bond
Gene Ontology (GO)
Biological process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Cysteine dioxygenase type 1		PRO_0000246081
Sites
	Metal binding	86	1	Iron; catalytic By similarity
	Metal binding	88	1	Iron; catalytic By similarity
	Metal binding	140	1	Iron; catalytic By similarity
Amino acid modifications
	Modified residue	59	1	Phosphothreonine By similarity
	Cross-link	93 ↔ 157		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZU4-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 65796B06507CF936	FASTA	200	23,013
	10 20 30 40 50 60 MERTEVLKPR TLADLIRVLH QLFAGEEINV EEVQAVMEAY ESNPAEWAVY AKFDQYRYTR 70 80 90 100 110 120 NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKMLQG NLKETLFAWP DKKSNEMIKK 130 140 150 160 170 180 SERILRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVIMT 190 200 FHSKFGIKTP FTTSGSLENN

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT025474 mRNA. Translation: ABF57430.1. BC102709 mRNA. Translation: AAI02710.1.
IPI	IPI00825885.
RefSeq	NP_001029637.1.
UniGene	Bt.2723
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SZU4.
Genome annotation databases
Ensembl	ENSBTAT00000023186; ENSBTAP00000023186; ENSBTAG00000017442; Bos taurus. [Genome view]
GeneID	514462.
KEGG	bta:514462.
Organism-specific databases
CTD	514462.
Phylogenomic databases
HOVERGEN	Q3SZU4.
Enzyme and pathway databases
BRENDA	1.13.11.20. 251.
Family and domain databases
InterPro	IPR010300. Cys_dOase_I. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDO1_BOVIN

Accession

Primary (citable) accession number: Q3SZU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 11, 2005
Last modified:	September 1, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)