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Q3SZT9

- CYC2_BOVIN

UniProt

Q3SZT9 - CYC2_BOVIN

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Protein
Cytochrome c 2
Gene
CYCT
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent) By similarity
Binding sitei18 – 181Heme (covalent) By similarity
Metal bindingi19 – 191Iron (heme axial ligand) By similarity
Metal bindingi81 – 811Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: Ensembl
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. hydrogen peroxide metabolic process Source: Ensembl
  3. oxidation-reduction process Source: UniProtKB-KW
  4. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c 2
Gene namesi
Name:CYCT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Mitochondrion intermembrane space By similarity
Note: Loosely associated with the inner membrane By similarity.

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 105104Cytochrome c 2
PRO_0000266018Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit By similarity.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3SZT9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031831.

Structurei

3D structure databases

ProteinModelPortaliQ3SZT9.
SMRiQ3SZT9. Positions 2-105.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiQ3SZT9.
KOiK08738.
OMAiAENIMAY.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZT9-1 [UniParc]FASTAAdd to Basket

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MADAEAGKKI FIQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT    50
EANKNKGIIW GEQTLMEYLE NPKKYIPGTK MIFAGLKKKS EREDLIEYLK 100
QATSS 105
Length:105
Mass (Da):11,740
Last modified:January 23, 2007 - v3
Checksum:i9E5AA14E7AAE7F39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102714 mRNA. Translation: AAI02715.1.
RefSeqiNP_001071431.1. NM_001077963.2.
XP_005202335.1. XM_005202278.1.
XP_005202336.1. XM_005202279.1.
UniGeneiBt.53549.

Genome annotation databases

EnsembliENSBTAT00000031885; ENSBTAP00000031831; ENSBTAG00000039522.
GeneIDi781996.
KEGGibta:781996.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102714 mRNA. Translation: AAI02715.1 .
RefSeqi NP_001071431.1. NM_001077963.2.
XP_005202335.1. XM_005202278.1.
XP_005202336.1. XM_005202279.1.
UniGenei Bt.53549.

3D structure databases

ProteinModelPortali Q3SZT9.
SMRi Q3SZT9. Positions 2-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000031831.

Proteomic databases

PRIDEi Q3SZT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000031885 ; ENSBTAP00000031831 ; ENSBTAG00000039522 .
GeneIDi 781996.
KEGGi bta:781996.

Organism-specific databases

CTDi 13067.

Phylogenomic databases

eggNOGi COG3474.
GeneTreei ENSGT00390000009405.
HOGENOMi HOG000009762.
HOVERGENi HBG003023.
InParanoidi Q3SZT9.
KOi K08738.
OMAi AENIMAY.
OrthoDBi EOG761BWX.
TreeFami TF300226.

Miscellaneous databases

NextBioi 20925172.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCYC2_BOVIN
AccessioniPrimary (citable) accession number: Q3SZT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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