Q3SZT9 (CYC2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c 2

Gene names

Name:

CYCT

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity. Note: Loosely associated with the inner membrane By similarity.
Post-translational modification	Binds 1 heme group per subunit By similarity. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration By similarity.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Apoptosis Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW hydrogen peroxide metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: Compara iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 105	104	Cytochrome c 2		PRO_0000266018
Sites
	Metal binding	19	1	Iron (heme axial ligand) By similarity
	Metal binding	81	1	Iron (heme axial ligand) By similarity
	Binding site	15	1	Heme (covalent) By similarity
	Binding site	18	1	Heme (covalent) By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	49	1	Phosphotyrosine By similarity
	Modified residue	98	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZT9 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9E5AA14E7AAE7F39	FASTA	105	11,740
	10 20 30 40 50 60 MADAEAGKKI FIQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT EANKNKGIIW 70 80 90 100 GEQTLMEYLE NPKKYIPGTK MIFAGLKKKS EREDLIEYLK QATSS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102714 mRNA. Translation: AAI02715.1.
IPI	IPI00690497.
RefSeq	NP_001071431.1. NM_001077963.2.
UniGene	Bt.53549.
3D structure databases
HSSP	HSSP built from PDB template 2B4Z based on UniProtKB P62894.
ProteinModelPortal	Q3SZT9.
SMR	Q3SZT9. Positions 2-105.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000031831.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000031885; ENSBTAP00000031831; ENSBTAG00000039522.
GeneID	781996.
KEGG	bta:781996.
Organism-specific databases
CTD	13067.
Phylogenomic databases
eggNOG	COG3474.
GeneTree	ENSGT00390000009405.
HOGENOM	HOG000009762.
HOVERGEN	HBG003023.
InParanoid	Q3SZT9.
KO	K08738.
OMA	IFIQKCA.
OrthoDB	EOG45DWQX.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
PANTHER	PTHR11961. PTHR11961. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20925172.

Entry information

Entry name

CYC2_BOVIN

Accession

Primary (citable) accession number: Q3SZT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program