Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c 2

Gene

CYCT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)PROSITE-ProRule annotation
Binding sitei18 – 181Heme (covalent)PROSITE-ProRule annotation
Metal bindingi19 – 191Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi81 – 811Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: GO_Central
  2. heme binding Source: Ensembl
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. hydrogen peroxide metabolic process Source: Ensembl
  2. mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  3. mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
  4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  5. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c 2
Gene namesi
Name:CYCT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 2

Subcellular locationi

Mitochondrion intermembrane space By similarity
Note: Loosely associated with the inner membrane.By similarity

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: GO_Central
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 105104Cytochrome c 2PRO_0000266018Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.By similarity
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3SZT9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031831.

Structurei

3D structure databases

ProteinModelPortaliQ3SZT9.
SMRiQ3SZT9. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiQ3SZT9.
KOiK08738.
OMAiNGALIYQ.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAEAGKKI FIQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT
60 70 80 90 100
EANKNKGIIW GEQTLMEYLE NPKKYIPGTK MIFAGLKKKS EREDLIEYLK

QATSS
Length:105
Mass (Da):11,740
Last modified:January 23, 2007 - v3
Checksum:i9E5AA14E7AAE7F39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102714 mRNA. Translation: AAI02715.1.
RefSeqiNP_001071431.1. NM_001077963.2.
XP_005202335.1. XM_005202278.2.
XP_010800162.1. XM_010801860.1.
UniGeneiBt.53549.

Genome annotation databases

EnsembliENSBTAT00000031885; ENSBTAP00000031831; ENSBTAG00000039522.
GeneIDi781996.
KEGGibta:781996.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102714 mRNA. Translation: AAI02715.1.
RefSeqiNP_001071431.1. NM_001077963.2.
XP_005202335.1. XM_005202278.2.
XP_010800162.1. XM_010801860.1.
UniGeneiBt.53549.

3D structure databases

ProteinModelPortaliQ3SZT9.
SMRiQ3SZT9. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031831.

Proteomic databases

PRIDEiQ3SZT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000031885; ENSBTAP00000031831; ENSBTAG00000039522.
GeneIDi781996.
KEGGibta:781996.

Organism-specific databases

CTDi13067.

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiQ3SZT9.
KOiK08738.
OMAiNGALIYQ.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Miscellaneous databases

NextBioi20925172.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCYC2_BOVIN
AccessioniPrimary (citable) accession number: Q3SZT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.