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Q3SZT9

- CYC2_BOVIN

UniProt

Q3SZT9 - CYC2_BOVIN

Protein

Cytochrome c 2

Gene

CYCT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.By similarity
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151Heme (covalent)PROSITE-ProRule annotation
    Binding sitei18 – 181Heme (covalent)PROSITE-ProRule annotation
    Metal bindingi19 – 191Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi81 – 811Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: Ensembl
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. hydrogen peroxide metabolic process Source: Ensembl
    3. oxidation-reduction process Source: UniProtKB-KW
    4. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl

    Keywords - Biological processi

    Apoptosis, Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c 2
    Gene namesi
    Name:CYCT
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Mitochondrion intermembrane space By similarity
    Note: Loosely associated with the inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 105104Cytochrome c 2PRO_0000266018Add
    BLAST

    Post-translational modificationi

    Binds 1 heme group per subunit.By similarity
    Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3SZT9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000031831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SZT9.
    SMRiQ3SZT9. Positions 2-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    HOGENOMiHOG000009762.
    HOVERGENiHBG003023.
    InParanoidiQ3SZT9.
    KOiK08738.
    OMAiAENIMAY.
    OrthoDBiEOG761BWX.
    TreeFamiTF300226.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SZT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAEAGKKI FIQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT    50
    EANKNKGIIW GEQTLMEYLE NPKKYIPGTK MIFAGLKKKS EREDLIEYLK 100
    QATSS 105
    Length:105
    Mass (Da):11,740
    Last modified:January 23, 2007 - v3
    Checksum:i9E5AA14E7AAE7F39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102714 mRNA. Translation: AAI02715.1.
    RefSeqiNP_001071431.1. NM_001077963.2.
    XP_005202335.1. XM_005202278.1.
    XP_005202336.1. XM_005202279.1.
    UniGeneiBt.53549.

    Genome annotation databases

    EnsembliENSBTAT00000031885; ENSBTAP00000031831; ENSBTAG00000039522.
    GeneIDi781996.
    KEGGibta:781996.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102714 mRNA. Translation: AAI02715.1 .
    RefSeqi NP_001071431.1. NM_001077963.2.
    XP_005202335.1. XM_005202278.1.
    XP_005202336.1. XM_005202279.1.
    UniGenei Bt.53549.

    3D structure databases

    ProteinModelPortali Q3SZT9.
    SMRi Q3SZT9. Positions 2-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000031831.

    Proteomic databases

    PRIDEi Q3SZT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000031885 ; ENSBTAP00000031831 ; ENSBTAG00000039522 .
    GeneIDi 781996.
    KEGGi bta:781996.

    Organism-specific databases

    CTDi 13067.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    HOGENOMi HOG000009762.
    HOVERGENi HBG003023.
    InParanoidi Q3SZT9.
    KOi K08738.
    OMAi AENIMAY.
    OrthoDBi EOG761BWX.
    TreeFami TF300226.

    Miscellaneous databases

    NextBioi 20925172.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiCYC2_BOVIN
    AccessioniPrimary (citable) accession number: Q3SZT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3