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Protein

Transmembrane protein 147

Gene

TMEM147

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 147
Gene namesi
Name:TMEM147
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:35978 TMEM147

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717001 – 224Transmembrane protein 147Add BLAST224

Proteomic databases

PaxDbiQ3SZR6
PRIDEiQ3SZR6

Expressioni

Gene expression databases

BgeeiENSBTAG00000015920

Interactioni

Subunit structurei

Forms a complex with NCLN and NOMO, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021170

Structurei

3D structure databases

SMRiQ3SZR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3236 Eukaryota
ENOG41101UF LUCA
GeneTreeiENSGT00390000013276
HOGENOMiHOG000005667
HOVERGENiHBG094059
InParanoidiQ3SZR6
OMAiEYNAFWR
OrthoDBiEOG091G0KEQ
TreeFamiTF314086

Family and domain databases

InterProiView protein in InterPro
IPR019164 TMEM147
PANTHERiPTHR12869 PTHR12869, 1 hit
PfamiView protein in Pfam
PF09767 DUF2053, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SZR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWKCVQAGV TYLFVQLCKM
60 70 80 90 100
LFLATFFPTW EGGIYDFIGE FMKASVDVAD LIGLNLVMSR NAGKGEYKIM
110 120 130 140 150
VAALGWATAE LIMSRCIPLW VGARGIEFDW KYIQMSIDSN ISLVHYIVAS
160 170 180 190 200
AQVWMITRYD LYHTYRPAVL LLMFLSVYKA FVMETFVHLC SLGSWTALLA
210 220
RALVTGLLAL STLALYVAVV NVHS
Length:224
Mass (Da):25,321
Last modified:October 11, 2005 - v1
Checksum:i90122F2DC80E96D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102737 mRNA Translation: AAI02738.1
RefSeqiNP_001029796.1, NM_001034624.1
UniGeneiBt.4533

Genome annotation databases

EnsembliENSBTAT00000021170; ENSBTAP00000021170; ENSBTAG00000015920
GeneIDi535038
KEGGibta:535038

Similar proteinsi

Entry informationi

Entry nameiTM147_BOVIN
AccessioniPrimary (citable) accession number: Q3SZR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health