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Protein

Transmembrane protein 147

Gene

TMEM147

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 147
Gene namesi
Name:TMEM147
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Transmembrane protein 147PRO_0000271700Add
BLAST

Proteomic databases

PaxDbiQ3SZR6.
PRIDEiQ3SZR6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015920.

Interactioni

Subunit structurei

Forms a complex with NCLN and NOMO, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021170.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3236. Eukaryota.
ENOG41101UF. LUCA.
GeneTreeiENSGT00390000013276.
HOGENOMiHOG000005667.
HOVERGENiHBG094059.
InParanoidiQ3SZR6.
OMAiEYNAFWR.
OrthoDBiEOG091G0KEQ.
TreeFamiTF314086.

Family and domain databases

InterProiIPR019164. DUF2053_membrane.
[Graphical view]
PANTHERiPTHR12869. PTHR12869. 1 hit.
PfamiPF09767. DUF2053. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWKCVQAGV TYLFVQLCKM
60 70 80 90 100
LFLATFFPTW EGGIYDFIGE FMKASVDVAD LIGLNLVMSR NAGKGEYKIM
110 120 130 140 150
VAALGWATAE LIMSRCIPLW VGARGIEFDW KYIQMSIDSN ISLVHYIVAS
160 170 180 190 200
AQVWMITRYD LYHTYRPAVL LLMFLSVYKA FVMETFVHLC SLGSWTALLA
210 220
RALVTGLLAL STLALYVAVV NVHS
Length:224
Mass (Da):25,321
Last modified:October 11, 2005 - v1
Checksum:i90122F2DC80E96D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102737 mRNA. Translation: AAI02738.1.
RefSeqiNP_001029796.1. NM_001034624.1.
UniGeneiBt.4533.

Genome annotation databases

EnsembliENSBTAT00000021170; ENSBTAP00000021170; ENSBTAG00000015920.
GeneIDi535038.
KEGGibta:535038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102737 mRNA. Translation: AAI02738.1.
RefSeqiNP_001029796.1. NM_001034624.1.
UniGeneiBt.4533.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021170.

Proteomic databases

PaxDbiQ3SZR6.
PRIDEiQ3SZR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021170; ENSBTAP00000021170; ENSBTAG00000015920.
GeneIDi535038.
KEGGibta:535038.

Organism-specific databases

CTDi10430.

Phylogenomic databases

eggNOGiKOG3236. Eukaryota.
ENOG41101UF. LUCA.
GeneTreeiENSGT00390000013276.
HOGENOMiHOG000005667.
HOVERGENiHBG094059.
InParanoidiQ3SZR6.
OMAiEYNAFWR.
OrthoDBiEOG091G0KEQ.
TreeFamiTF314086.

Gene expression databases

BgeeiENSBTAG00000015920.

Family and domain databases

InterProiIPR019164. DUF2053_membrane.
[Graphical view]
PANTHERiPTHR12869. PTHR12869. 1 hit.
PfamiPF09767. DUF2053. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM147_BOVIN
AccessioniPrimary (citable) accession number: Q3SZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.