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Protein

Alpha-1-acid glycoprotein

Gene

ORM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAcute phase, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein
Alternative name(s):
Orosomucoid
Short name:
OMD
Gene namesi
Name:ORM1
Synonyms:AGP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000027139519 – 202Alpha-1-acid glycoproteinAdd BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 184By similarity
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3SZR3
PeptideAtlasiQ3SZR3
PRIDEiQ3SZR3

PTM databases

GlyConnecti693
UniCarbKBiQ3SZR3

Miscellaneous databases

PMAP-CutDBiQ3SZR3

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022991

Structurei

3D structure databases

ProteinModelPortaliQ3SZR3
SMRiQ3SZR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI Eukaryota
ENOG4111C49 LUCA
HOGENOMiHOG000125170
HOVERGENiHBG000035
InParanoidiQ3SZR3
KOiK17308

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11967 PTHR11967, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036899 AGP, 1 hit
PRINTSiPR00708 A1AGLPROTEIN
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWALAVL SHLPLLDAQS PECANLMTVA PITNATMDLL SGKWFYIGSA
60 70 80 90 100
FRNPEYNKSA RAIQAAFFYL EPRHAEDKLI TREYQTIEDK CVYNCSFIKI
110 120 130 140 150
YRQNGTLSKV ESDREHFVDL LLSKHFRTFM LAASWNGTKN VGVSFYADKP
160 170 180 190 200
EVTQEQKKEF LDVIKCIGIQ ESEIIYTDEK KDACGPLEKQ HEEERKKETE

AS
Length:202
Mass (Da):23,182
Last modified:October 11, 2005 - v1
Checksum:iB6EF3A1691BCCF2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102740 mRNA Translation: AAI02741.1
RefSeqiNP_001035592.1, NM_001040502.2
UniGeneiBt.49064

Genome annotation databases

GeneIDi497200
KEGGibta:497200

Entry informationi

Entry nameiA1AG_BOVIN
AccessioniPrimary (citable) accession number: Q3SZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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