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Protein

Alpha-1-acid glycoprotein

Gene

ORM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein
Alternative name(s):
Orosomucoid
Short name:
OMD
Gene namesi
Name:ORM1
Synonyms:AGP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 202184Alpha-1-acid glycoproteinPRO_0000271395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 184By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3SZR3.
PRIDEiQ3SZR3.

PTM databases

UniCarbKBiQ3SZR3.

Miscellaneous databases

PMAP-CutDBQ3SZR3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022991.

Structurei

3D structure databases

ProteinModelPortaliQ3SZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiQ3SZR3.
KOiK17308.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWALAVL SHLPLLDAQS PECANLMTVA PITNATMDLL SGKWFYIGSA
60 70 80 90 100
FRNPEYNKSA RAIQAAFFYL EPRHAEDKLI TREYQTIEDK CVYNCSFIKI
110 120 130 140 150
YRQNGTLSKV ESDREHFVDL LLSKHFRTFM LAASWNGTKN VGVSFYADKP
160 170 180 190 200
EVTQEQKKEF LDVIKCIGIQ ESEIIYTDEK KDACGPLEKQ HEEERKKETE

AS
Length:202
Mass (Da):23,182
Last modified:October 11, 2005 - v1
Checksum:iB6EF3A1691BCCF2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102740 mRNA. Translation: AAI02741.1.
RefSeqiNP_001035592.1. NM_001040502.2.
UniGeneiBt.49064.

Genome annotation databases

GeneIDi497200.
KEGGibta:497200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102740 mRNA. Translation: AAI02741.1.
RefSeqiNP_001035592.1. NM_001040502.2.
UniGeneiBt.49064.

3D structure databases

ProteinModelPortaliQ3SZR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022991.

PTM databases

UniCarbKBiQ3SZR3.

Proteomic databases

PaxDbiQ3SZR3.
PRIDEiQ3SZR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi497200.
KEGGibta:497200.

Organism-specific databases

CTDi5004.

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiQ3SZR3.
KOiK17308.

Miscellaneous databases

PMAP-CutDBQ3SZR3.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiA1AG_BOVIN
AccessioniPrimary (citable) accession number: Q3SZR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.