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Protein

Solute carrier family 22 member 17

Gene

SLC22A17

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

ReactomeiR-BTA-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Lipocalin-2 receptor
Gene namesi
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:34725 SLC22A17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei350 – 369HelicalSequence analysisAdd BLAST20
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986321 – 567Solute carrier family 22 member 17Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3SZQ2

Expressioni

Gene expression databases

BgeeiENSBTAG00000016467

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036264

Structurei

3D structure databases

ProteinModelPortaliQ3SZQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7 Eukaryota
ENOG411129W LUCA
GeneTreeiENSGT00390000014377
HOGENOMiHOG000015298
HOVERGENiHBG031124
InParanoidiQ3SZQ2
KOiK08213
OMAiPSFYWTY
OrthoDBiEOG091G07Y4
TreeFamiTF335753

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequencei

Sequence statusi: Complete.

Q3SZQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSLSLAVP PGPLSFEALL AQVGALGGGQ QLQLGLCCLP VLFVALGLAS
60 70 80 90 100
DPIFTLAPPL HCHYGAFPPN ASGWEQPPNA SGVSVASAAL AASAASRLAT
110 120 130 140 150
STDPSCSGFA PPDFNHCLKD WDYNGLPVLT TNAIGQWDLV CDLGWQVILE
160 170 180 190 200
QILFILGFAS GYLFLGYPAD RFGRRGIVLL TLGLVGPCGV GGAAAGSSTG
210 220 230 240 250
VMALRFLLGF LLAGVDLGVY LMRLELCDPT QRLRVALAGE LVGVGGHFLF
260 270 280 290 300
LGLALVSKDW RFLQRMITAP CILFLFYGWP GLFLESARWL IVKRQIEEAQ
310 320 330 340 350
SVLRILAERN RPHGQMLGEE AQEALQDLEN TCPLPATSSF SFASLLNYRN
360 370 380 390 400
IWKNLLILGF TNFIAHAIRH CYQPVGGGGS PSDFYLCSLL ASGTAALACV
410 420 430 440 450
FLGVTVDRFG RRGILLLSMT LTGIASLALL GLWDYLNEAA ITTFSVLGLF
460 470 480 490 500
SSQAAGILST LLAAEVIPTT VRGRGLGLIM ALGALGGLSG PAQRLHMGHG
510 520 530 540 550
AFLQHVVLAA CALLCILSIM LLPETKRKLL PEVLRDGELC RRPSLLQQPP
560
PNRCDHVPLL ATPNPAL
Length:567
Mass (Da):60,174
Last modified:October 11, 2005 - v1
Checksum:i963A0EBC3DCAEE8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102752 mRNA Translation: AAI02753.2
RefSeqiNP_001124227.1, NM_001130755.2
XP_010807280.1, XM_010808978.2
UniGeneiBt.108326
Bt.48982

Genome annotation databases

EnsembliENSBTAT00000036406; ENSBTAP00000036264; ENSBTAG00000016467
GeneIDi539848
KEGGibta:539848

Similar proteinsi

Entry informationi

Entry nameiS22AH_BOVIN
AccessioniPrimary (citable) accession number: Q3SZQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health