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Protein

Solute carrier family 22 member 17

Gene

SLC22A17

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Lipocalin-2 receptor
Gene namesi
Name:SLC22A17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei350 – 369HelicalSequence analysisAdd BLAST20
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986321 – 567Solute carrier family 22 member 17Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3SZQ2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016467.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036264.

Structurei

3D structure databases

ProteinModelPortaliQ3SZQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ3SZQ2.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG091G07Y4.
TreeFamiTF335753.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSLSLAVP PGPLSFEALL AQVGALGGGQ QLQLGLCCLP VLFVALGLAS
60 70 80 90 100
DPIFTLAPPL HCHYGAFPPN ASGWEQPPNA SGVSVASAAL AASAASRLAT
110 120 130 140 150
STDPSCSGFA PPDFNHCLKD WDYNGLPVLT TNAIGQWDLV CDLGWQVILE
160 170 180 190 200
QILFILGFAS GYLFLGYPAD RFGRRGIVLL TLGLVGPCGV GGAAAGSSTG
210 220 230 240 250
VMALRFLLGF LLAGVDLGVY LMRLELCDPT QRLRVALAGE LVGVGGHFLF
260 270 280 290 300
LGLALVSKDW RFLQRMITAP CILFLFYGWP GLFLESARWL IVKRQIEEAQ
310 320 330 340 350
SVLRILAERN RPHGQMLGEE AQEALQDLEN TCPLPATSSF SFASLLNYRN
360 370 380 390 400
IWKNLLILGF TNFIAHAIRH CYQPVGGGGS PSDFYLCSLL ASGTAALACV
410 420 430 440 450
FLGVTVDRFG RRGILLLSMT LTGIASLALL GLWDYLNEAA ITTFSVLGLF
460 470 480 490 500
SSQAAGILST LLAAEVIPTT VRGRGLGLIM ALGALGGLSG PAQRLHMGHG
510 520 530 540 550
AFLQHVVLAA CALLCILSIM LLPETKRKLL PEVLRDGELC RRPSLLQQPP
560
PNRCDHVPLL ATPNPAL
Length:567
Mass (Da):60,174
Last modified:October 11, 2005 - v1
Checksum:i963A0EBC3DCAEE8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102752 mRNA. Translation: AAI02753.2.
RefSeqiNP_001124227.1. NM_001130755.2.
XP_010807280.1. XM_010808978.2.
UniGeneiBt.108326.
Bt.48982.

Genome annotation databases

EnsembliENSBTAT00000036406; ENSBTAP00000036264; ENSBTAG00000016467.
GeneIDi539848.
KEGGibta:539848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102752 mRNA. Translation: AAI02753.2.
RefSeqiNP_001124227.1. NM_001130755.2.
XP_010807280.1. XM_010808978.2.
UniGeneiBt.108326.
Bt.48982.

3D structure databases

ProteinModelPortaliQ3SZQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036264.

Proteomic databases

PaxDbiQ3SZQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036406; ENSBTAP00000036264; ENSBTAG00000016467.
GeneIDi539848.
KEGGibta:539848.

Organism-specific databases

CTDi51310.

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000015298.
HOVERGENiHBG031124.
InParanoidiQ3SZQ2.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG091G07Y4.
TreeFamiTF335753.

Gene expression databases

BgeeiENSBTAG00000016467.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AH_BOVIN
AccessioniPrimary (citable) accession number: Q3SZQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.