ID   ACOX1_BOVIN             Reviewed;         660 AA.
AC   Q3SZP5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Peroxisomal acyl-coenzyme A oxidase 1;
DE            Short=AOX;
DE            EC=1.3.3.6;
DE   AltName: Full=Palmitoyl-CoA oxidase;
GN   Name=ACOX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the desaturation of very long chain acyl-CoAs
CC       to 2-trans-enoyl-CoAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA +
CC       H(2)O(2).
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC   -!- SUBCELLULAR LOCATION: Peroxisome (By similarity).
CC   -!- SIMILARITY: Belongs to the acyl-CoA oxidase family.
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DR   EMBL; BC102761; AAI02762.1; -; mRNA.
DR   IPI; IPI00693965; -.
DR   RefSeq; NP_001030366.1; -.
DR   UniGene; Bt.23818; -.
DR   SMR; Q3SZP5; 1-654.
DR   Ensembl; ENSBTAG00000030174; Bos taurus.
DR   GeneID; 513996; -.
DR   KEGG; bta:513996; -.
DR   HOVERGEN; Q3SZP5; -.
DR   BRENDA; 1.3.3.6; 251.
DR   GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0003997; F:acyl-CoA oxidase activity; ISS:UniProtKB.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:InterPro.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; ISS:UniProtKB.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006693; P:prostaglandin metabolic process; ISS:UniProtKB.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_M.
DR   InterPro; IPR012258; Acyl-CoA_oxidase.
DR   InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2.
DR   PANTHER; PTHR10909:SF11; Acyl-CoA_oxidase; 1.
DR   Pfam; PF01756; ACOX; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; FAD; Fatty acid metabolism; Flavoprotein;
KW   Lipid metabolism; Oxidoreductase; Peroxisome; Phosphoprotein.
FT   CHAIN         1    660       Peroxisomal acyl-coenzyme A oxidase 1.
FT                                /FTId=PRO_0000281996.
FT   MOTIF       658    660       Microbody targeting signal (By
FT                                similarity).
FT   ACT_SITE    421    421       Proton acceptor (By similarity).
FT   BINDING     139    139       FAD (By similarity).
FT   BINDING     178    178       FAD; via amide nitrogen (By similarity).
FT   MOD_RES      26     26       Phosphoserine (By similarity).
FT   MOD_RES     267    267       N6-acetyllysine (By similarity).
FT   MOD_RES     310    310       Phosphoserine (By similarity).
FT   MOD_RES     643    643       N6-acetyllysine (By similarity).
FT   MOD_RES     649    649       Phosphoserine (By similarity).
SQ   SEQUENCE   660 AA;  74379 MW;  606F86A63915DF9D CRC64;
     MNPDLQKERA GASFNPELLT NVLDGSPENT RRRREIENLI LNDPDFQHEN LNFLSRSQRY
     EVAVKKSAIM VQKMRKFGIA DPAEIMWFKK LHLVNFVEPV GLNYSMFIPT LLNQGTTAQQ
     EKWLHSSKGL EIIGTYAQTE MGHGTHLRGL ETTATYDPET QEFILNSPTV TSIKWWPGGL
     GKTSNHAIVL AQLFTQGKCY GLHAFIVPIR ELGTHKPLPG ITVGDIGPKF GYDEMDNGYL
     KMDNYRIPRE NMLMKHAQVK PDGTYVKPLN NKLTYGTMVF IRSFLVGESA RSLSKACTIA
     VRYSAVRHQS EINPGEPEPQ ILDYQTQQYK LFPLLATAYA FQFVGAYMKE TYLRINEDIG
     HGDLSELPEL HALTAGLKAF TSWTTNTAIE ACRMACGGHG YSHCSGLPNI YVTFTPTCTF
     EGENTVMMLQ TARFLMKSYD QVHSGKLVCG MVSYLNDLPS QRIQPQQVAV WPTMVDINSP
     DSLTEAYKLR AARLVEIAAK NLQTEVIHRK SKEVAWNLTS IDLVRASEAH CHYVVVKLFT
     EKVLQIQEKS IQAVLRRLCL LYSLYGISQN AGDFLQGSIM TESQITQVNG RIKELLTAIR
     PDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY KHLKSLQSKL
//