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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139FADBy similarity1
Binding sitei178FAD; via amide nitrogenBy similarity1
Active sitei421Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1 (EC:1.3.3.6)
Short name:
AOX
Alternative name(s):
Palmitoyl-CoA oxidase
Gene namesi
Name:ACOX1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002819961 – 660Peroxisomal acyl-coenzyme A oxidase 1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1
Modified residuei65N6-acetyllysineBy similarity1
Modified residuei89N6-succinyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei216N6-acetyllysineBy similarity1
Modified residuei241N6-succinyllysineBy similarity1
Modified residuei255N6-acetyllysineBy similarity1
Modified residuei267N6-acetyllysineBy similarity1
Modified residuei272N6-acetyllysineBy similarity1
Modified residuei349N6-succinyllysineBy similarity1
Modified residuei437N6-acetyllysine; alternateBy similarity1
Modified residuei437N6-succinyllysine; alternateBy similarity1
Modified residuei446N6-acetyllysine; alternateBy similarity1
Modified residuei446N6-succinyllysine; alternateBy similarity1
Modified residuei500N6-acetyllysineBy similarity1
Modified residuei512N6-acetyllysine; alternateBy similarity1
Modified residuei512N6-succinyllysine; alternateBy similarity1
Modified residuei542N6-succinyllysineBy similarity1
Modified residuei637N6-acetyllysine; alternateBy similarity1
Modified residuei637N6-succinyllysine; alternateBy similarity1
Modified residuei643N6-succinyllysineBy similarity1
Modified residuei649PhosphoserineBy similarity1
Modified residuei651N6-acetyllysineBy similarity1
Modified residuei654N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SZP5.
PeptideAtlasiQ3SZP5.
PRIDEiQ3SZP5.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029362.

Structurei

3D structure databases

ProteinModelPortaliQ3SZP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi658 – 660Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000181256.
HOVERGENiHBG050451.
InParanoidiQ3SZP5.
KOiK00232.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SZP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLQKERA GASFNPELLT NVLDGSPENT RRRREIENLI LNDPDFQHEN
60 70 80 90 100
LNFLSRSQRY EVAVKKSAIM VQKMRKFGIA DPAEIMWFKK LHLVNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWLHSSKGL EIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLFTQGKCY
210 220 230 240 250
GLHAFIVPIR ELGTHKPLPG ITVGDIGPKF GYDEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKHAQVK PDGTYVKPLN NKLTYGTMVF IRSFLVGESA RSLSKACTIA
310 320 330 340 350
VRYSAVRHQS EINPGEPEPQ ILDYQTQQYK LFPLLATAYA FQFVGAYMKE
360 370 380 390 400
TYLRINEDIG HGDLSELPEL HALTAGLKAF TSWTTNTAIE ACRMACGGHG
410 420 430 440 450
YSHCSGLPNI YVTFTPTCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG
460 470 480 490 500
MVSYLNDLPS QRIQPQQVAV WPTMVDINSP DSLTEAYKLR AARLVEIAAK
510 520 530 540 550
NLQTEVIHRK SKEVAWNLTS IDLVRASEAH CHYVVVKLFT EKVLQIQEKS
560 570 580 590 600
IQAVLRRLCL LYSLYGISQN AGDFLQGSIM TESQITQVNG RIKELLTAIR
610 620 630 640 650
PDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
KHLKSLQSKL
Length:660
Mass (Da):74,379
Last modified:October 11, 2005 - v1
Checksum:i606F86A63915DF9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102761 mRNA. Translation: AAI02762.1.
RefSeqiNP_001030366.1. NM_001035289.3.
UniGeneiBt.23818.

Genome annotation databases

GeneIDi513996.
KEGGibta:513996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102761 mRNA. Translation: AAI02762.1.
RefSeqiNP_001030366.1. NM_001035289.3.
UniGeneiBt.23818.

3D structure databases

ProteinModelPortaliQ3SZP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029362.

Proteomic databases

PaxDbiQ3SZP5.
PeptideAtlasiQ3SZP5.
PRIDEiQ3SZP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi513996.
KEGGibta:513996.

Organism-specific databases

CTDi51.

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000181256.
HOVERGENiHBG050451.
InParanoidiQ3SZP5.
KOiK00232.

Enzyme and pathway databases

UniPathwayiUPA00661.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACOX1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: October 5, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.