Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metalloendopeptidase OMA1, mitochondrial

Gene

OMA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi327Zinc; catalyticPROSITE-ProRule annotation1
Active sitei328PROSITE-ProRule annotation1
Metal bindingi331Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi392Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-169911 Regulation of Apoptosis

Protein family/group databases

MEROPSiM48.017

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloendopeptidase OMA1, mitochondrial (EC:3.4.24.-)
Alternative name(s):
Overlapping with the m-AAA protease 1 homolog
Gene namesi
Name:OMA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:32428 OMA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
ChainiPRO_000030280846 – 523Metalloendopeptidase OMA1, mitochondrialAdd BLAST478

Post-translational modificationi

In normal conditions, cleaved into an inactive 40 kDa form. Following CCCP treatment that induces loss of mitochondrial membrane potential, the 40 kDa form is reduced in favor of an active 60 kDa form (By similarity).By similarity

Proteomic databases

PaxDbiQ3SZN3
PRIDEiQ3SZN3

Expressioni

Gene expression databases

BgeeiENSBTAG00000017326

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023044

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2661 Eukaryota
COG0501 LUCA
GeneTreeiENSGT00390000007027
HOGENOMiHOG000115266
HOVERGENiHBG096685
InParanoidiQ3SZN3
OMAiFLTMIWA
OrthoDBiEOG091G087J
TreeFamiTF329133

Family and domain databases

InterProiView protein in InterPro
IPR001915 Peptidase_M48
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIYGLQSA ARNCFFFRFN LLTNWRKCNT QAVTSRDFHQ VKINHIVNKS
60 70 80 90 100
LGLGVNHGDR WTPLPENFLF YRTFNTKRKG CLLSSRSKEI WMISRKCTAW
110 120 130 140 150
TDSFSRQLPM KNVPVVPAHS MSHPLNCLPT RDIRSFHTSP RCQAAPAPLL
160 170 180 190 200
LMILKPAQKL LAIIVGRGIR KWWQALPPNK KELFKESLRK NKWKLFLGLS
210 220 230 240 250
SFGLLFVVFY FTHLEVSPVT GRSKLLILGK EHFRLLSELE YEAWMEEFKN
260 270 280 290 300
DMLTEKDARY VAVKAVVHHL IECNQDIPGI SEINWIIHVV DSPDINAFVL
310 320 330 340 350
PNGQVFVFTG LLNSVTDIHQ LSFLLGHEIA HAVLEHAAEK ASLVHLLDFL
360 370 380 390 400
GLIFLTTIWA ICPRDSLALL GQWIQSKLQE FLFDRPYSRT LEAEADRIGL
410 420 430 440 450
QLAAKACVDV RASSVFWQQM EFAESLHGHP KLPEWLSTHP SHGNRAEHLD
460 470 480 490 500
RLIPQALKIR ETCNCPPLSG PDPRLLFKLS MKNFLEAEKE DLNITVKQKM
510 520
DALPIQNQKQ IPLTCIVDKR TGS
Length:523
Mass (Da):59,896
Last modified:May 16, 2012 - v2
Checksum:iA26E8867EE43A1A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti477F → L in AAI02775 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02008763 Genomic DNA No translation available.
BC102774 mRNA Translation: AAI02775.1
RefSeqiNP_001030205.1, NM_001035033.2
XP_005204593.1, XM_005204536.2
UniGeneiBt.27779

Genome annotation databases

EnsembliENSBTAT00000023044; ENSBTAP00000023044; ENSBTAG00000017326
GeneIDi506223
KEGGibta:506223

Similar proteinsi

Entry informationi

Entry nameiOMA1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZN3
Secondary accession number(s): F1N0Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 16, 2012
Last modified: March 28, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health