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Protein

Protein transport protein Sec23B

Gene

SEC23B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23BCurated
Alternative name(s):
SEC23-related protein B
Gene namesi
Name:SEC23BBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002453442 – 767Protein transport protein Sec23BAdd BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei564N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZN2.
PeptideAtlasiQ3SZN2.
PRIDEiQ3SZN2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018295.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SAR1A (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024348.

Structurei

3D structure databases

ProteinModelPortaliQ3SZN2.
SMRiQ3SZN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati634 – 720Gelsolin-likeSequence analysisAdd BLAST87

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ3SZN2.
KOiK14006.
OMAiPQEHPFV.
OrthoDBiEOG091G063R.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
PfamiView protein in Pfam
PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD
60 70 80 90 100
LPPVQYEPVL CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG
110 120 130 140 150
ISEVNQPAEL MPQFSTIEYV IQRGAPSPLI FLYVVDTCLE DDDLQALKES
160 170 180 190 200
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI
210 220 230 240 250
QDMLGLTKPA MPVQPMRPAQ PQERPSVSSR FLQPIHKIDM NLTDLLGELQ
260 270 280 290 300
RDPWPVPQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
310 320 330 340 350
GMVVGDELKV PIRSWHDIEK DNARFMKKAT KHYEMLANRT AANGHCIDIY
360 370 380 390 400
ACALDQTGLL EMKCCPNLTG GYMVMGDSFN TSLFKQTFQR IFSKDFNGNF
410 420 430 440 450
RMAFGATLEV KTSRELKVAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI
460 470 480 490 500
CGLDPTTTLG IYFEVVNQHN APIPQGGRGA IQFVTHYQHS STQRRIRVTT
510 520 530 540 550
VARNWADVQS QLKHIEAAFD QEAAAVLMAR LGVFRAETEE GPDVLRWLDR
560 570 580 590 600
QLIRLCQKFG QYNKEDPMSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD
610 620 630 640 650
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL
660 670 680 690 700
LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA
710 720 730 740 750
RFPMPRYIHT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS
760
LQVFMDHLKK LAVSSAC
Length:767
Mass (Da):86,462
Last modified:October 11, 2005 - v1
Checksum:i0436D64B2F8840F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102775 mRNA. Translation: AAI02776.1.
RefSeqiNP_001029798.1. NM_001034626.2.
XP_005214413.1. XM_005214356.3.
XP_005214414.1. XM_005214357.3.
XP_005214415.1. XM_005214358.3.
XP_005214417.1. XM_005214360.3.
XP_005214418.1. XM_005214361.3.
XP_005214419.1. XM_005214362.3.
XP_005214420.1. XM_005214363.3.
XP_015329520.1. XM_015474034.1.
UniGeneiBt.48826.

Genome annotation databases

EnsembliENSBTAT00000024348; ENSBTAP00000024348; ENSBTAG00000018295.
GeneIDi535071.
KEGGibta:535071.

Similar proteinsi

Entry informationi

Entry nameiSC23B_BOVIN
AccessioniPrimary (citable) accession number: Q3SZN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families