ID   NAGK_BOVIN              Reviewed;         344 AA.
AC   Q3SZM9;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   05-MAY-2009, entry version 26.
DE   RecName: Full=N-acetyl-D-glucosamine kinase;
DE            Short=N-acetylglucosamine kinase;
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase;
GN   Name=NAGK;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a
CC       major component of complex carbohydrates, from lysosomal
CC       degradation or nutritional sources into GlcNAc 6-phosphate. Also
CC       has ManNAc kinase activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-
CC       D-glucosamine 6-phosphate.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the eukaryotic-type N-acetylglucosamine
CC       kinase family.
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DR   EMBL; BC102780; AAI02781.1; -; mRNA.
DR   IPI; IPI00718059; -.
DR   RefSeq; NP_001029486.1; -.
DR   UniGene; Bt.4387; -.
DR   SMR; Q3SZM9; 1-344.
DR   Ensembl; ENSBTAG00000014668; Bos taurus.
DR   GeneID; 508132; -.
DR   KEGG; bta:508132; -.
DR   HOVERGEN; Q3SZM9; -.
DR   OMA; Q3SZM9; RDRFPYL.
DR   BRENDA; 2.7.1.59; 251.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; IEA:EC.
DR   InterPro; IPR002731; ATPase_BadF.
DR   Pfam; PF01869; BcrAD_BadFG; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Transferase.
FT   CHAIN         1    344       N-acetyl-D-glucosamine kinase.
FT                                /FTId=PRO_0000253473.
FT   NP_BIND       6     13       ATP (By similarity).
FT   REGION      129    130       Substrate binding (By similarity).
FT   REGION      145    147       Substrate binding (By similarity).
FT   BINDING      36     36       Substrate (By similarity).
FT   BINDING     107    107       Substrate (By similarity).
FT   BINDING     152    152       Substrate (By similarity).
FT   BINDING     271    271       ATP (By similarity).
FT   BINDING     275    275       ATP (By similarity).
FT   MOD_RES      76     76       Phosphoserine (By similarity).
FT   MOD_RES     205    205       Phosphotyrosine (By similarity).
SQ   SEQUENCE   344 AA;  37268 MW;  575EC6F41FA4BA08 CRC64;
     MVTLYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDKCVERIN EMVNRAKRKA
     GVDPLVPLRG LGLSLSGGDQ EDAVRMLMEE LRDRFPYLSE SYLITTDAAG SIATATPDGG
     VVLISGTGSN CRLINPDGSE SGCGGWGHMM GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD
     IGYVKQAMFN YFQVPDRLGI LTHLYRDFDK SRFAGFCRKV AEGAQQGDPL SRCIFRKAGE
     MLGRHVVAVL PEIDPVLFQG EMGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNSFS
     GFTLLKLRHS SALGAASLGA KHIGHLLPMD YSTSAIAFYS YTFS
//