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Q3SZM9

- NAGK_BOVIN

UniProt

Q3SZM9 - NAGK_BOVIN

Protein

N-acetyl-D-glucosamine kinase

Gene

NAGK

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity By similarity.By similarity

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei107 – 1071SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei271 – 2711ATPBy similarity
    Binding sitei275 – 2751ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 138ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. N-acetylglucosamine kinase activity Source: UniProtKB
    3. N-acylmannosamine kinase activity Source: Ensembl

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. N-acetylglucosamine metabolic process Source: Ensembl
    3. N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00629.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
    Short name:
    N-acetylglucosamine kinase
    Alternative name(s):
    GlcNAc kinase
    Gene namesi
    Name:NAGK
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 344343N-acetyl-D-glucosamine kinasePRO_0000253473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761PhosphoserineBy similarity
    Modified residuei205 – 2051PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3SZM9.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000019528.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SZM9.
    SMRiQ3SZM9. Positions 4-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1302Substrate bindingBy similarity
    Regioni145 – 1473Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2971.
    GeneTreeiENSGT00510000047418.
    HOGENOMiHOG000007248.
    HOVERGENiHBG052570.
    InParanoidiQ3SZM9.
    KOiK00884.
    OMAiAFYSYTF.
    OrthoDBiEOG7V1FR7.
    TreeFamiTF314158.

    Family and domain databases

    InterProiIPR002731. ATPase_BadF.
    [Graphical view]
    PfamiPF01869. BcrAD_BadFG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SZM9-1 [UniParc]FASTAAdd to Basket

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    MVTLYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDKCVERIN    50
    EMVNRAKRKA GVDPLVPLRG LGLSLSGGDQ EDAVRMLMEE LRDRFPYLSE 100
    SYLITTDAAG SIATATPDGG VVLISGTGSN CRLINPDGSE SGCGGWGHMM 150
    GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD IGYVKQAMFN YFQVPDRLGI 200
    LTHLYRDFDK SRFAGFCRKV AEGAQQGDPL SRCIFRKAGE MLGRHVVAVL 250
    PEIDPVLFQG EMGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNSFS 300
    GFTLLKLRHS SALGAASLGA KHIGHLLPMD YSTSAIAFYS YTFS 344
    Length:344
    Mass (Da):37,268
    Last modified:October 11, 2005 - v1
    Checksum:i575EC6F41FA4BA08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102780 mRNA. Translation: AAI02781.1.
    RefSeqiNP_001029486.1. NM_001034314.2.
    UniGeneiBt.4387.

    Genome annotation databases

    EnsembliENSBTAT00000019528; ENSBTAP00000019528; ENSBTAG00000014668.
    GeneIDi508132.
    KEGGibta:508132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102780 mRNA. Translation: AAI02781.1 .
    RefSeqi NP_001029486.1. NM_001034314.2.
    UniGenei Bt.4387.

    3D structure databases

    ProteinModelPortali Q3SZM9.
    SMRi Q3SZM9. Positions 4-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000019528.

    Proteomic databases

    PRIDEi Q3SZM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000019528 ; ENSBTAP00000019528 ; ENSBTAG00000014668 .
    GeneIDi 508132.
    KEGGi bta:508132.

    Organism-specific databases

    CTDi 55577.

    Phylogenomic databases

    eggNOGi COG2971.
    GeneTreei ENSGT00510000047418.
    HOGENOMi HOG000007248.
    HOVERGENi HBG052570.
    InParanoidi Q3SZM9.
    KOi K00884.
    OMAi AFYSYTF.
    OrthoDBi EOG7V1FR7.
    TreeFami TF314158.

    Enzyme and pathway databases

    UniPathwayi UPA00629 .

    Miscellaneous databases

    NextBioi 20868366.

    Family and domain databases

    InterProi IPR002731. ATPase_BadF.
    [Graphical view ]
    Pfami PF01869. BcrAD_BadFG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiNAGK_BOVIN
    AccessioniPrimary (citable) accession number: Q3SZM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3