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Protein

N-acetyl-D-glucosamine kinase

Gene

NAGK

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity).By similarity

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei271 – 2711ATPBy similarity
Binding sitei275 – 2751ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. N-acetylglucosamine kinase activity Source: UniProtKB
  3. N-acylmannosamine kinase activity Source: Ensembl

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. N-acetylglucosamine metabolic process Source: Ensembl
  3. N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Short name:
N-acetylglucosamine kinase
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:NAGK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 344343N-acetyl-D-glucosamine kinasePRO_0000253473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphoserineBy similarity
Modified residuei205 – 2051PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3SZM9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019528.

Structurei

3D structure databases

ProteinModelPortaliQ3SZM9.
SMRiQ3SZM9. Positions 4-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1302Substrate bindingBy similarity
Regioni145 – 1473Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2971.
GeneTreeiENSGT00510000047418.
HOGENOMiHOG000007248.
HOVERGENiHBG052570.
InParanoidiQ3SZM9.
KOiK00884.
OMAiLLPMDYS.
OrthoDBiEOG7V1FR7.
TreeFamiTF314158.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDKCVERIN
60 70 80 90 100
EMVNRAKRKA GVDPLVPLRG LGLSLSGGDQ EDAVRMLMEE LRDRFPYLSE
110 120 130 140 150
SYLITTDAAG SIATATPDGG VVLISGTGSN CRLINPDGSE SGCGGWGHMM
160 170 180 190 200
GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD IGYVKQAMFN YFQVPDRLGI
210 220 230 240 250
LTHLYRDFDK SRFAGFCRKV AEGAQQGDPL SRCIFRKAGE MLGRHVVAVL
260 270 280 290 300
PEIDPVLFQG EMGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNSFS
310 320 330 340
GFTLLKLRHS SALGAASLGA KHIGHLLPMD YSTSAIAFYS YTFS
Length:344
Mass (Da):37,268
Last modified:October 11, 2005 - v1
Checksum:i575EC6F41FA4BA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102780 mRNA. Translation: AAI02781.1.
RefSeqiNP_001029486.1. NM_001034314.2.
UniGeneiBt.4387.

Genome annotation databases

EnsembliENSBTAT00000019528; ENSBTAP00000019528; ENSBTAG00000014668.
GeneIDi508132.
KEGGibta:508132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102780 mRNA. Translation: AAI02781.1.
RefSeqiNP_001029486.1. NM_001034314.2.
UniGeneiBt.4387.

3D structure databases

ProteinModelPortaliQ3SZM9.
SMRiQ3SZM9. Positions 4-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019528.

Proteomic databases

PRIDEiQ3SZM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019528; ENSBTAP00000019528; ENSBTAG00000014668.
GeneIDi508132.
KEGGibta:508132.

Organism-specific databases

CTDi55577.

Phylogenomic databases

eggNOGiCOG2971.
GeneTreeiENSGT00510000047418.
HOGENOMiHOG000007248.
HOVERGENiHBG052570.
InParanoidiQ3SZM9.
KOiK00884.
OMAiLLPMDYS.
OrthoDBiEOG7V1FR7.
TreeFamiTF314158.

Enzyme and pathway databases

UniPathwayiUPA00629.

Miscellaneous databases

NextBioi20868366.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiNAGK_BOVIN
AccessioniPrimary (citable) accession number: Q3SZM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.