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Q3SZM9 (NAGK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

Short name=N-acetylglucosamine kinase
EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:NAGK
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity By similarity.

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 344343N-acetyl-D-glucosamine kinase
PRO_0000253473

Regions

Nucleotide binding6 – 138ATP By similarity
Region129 – 1302Substrate binding By similarity
Region145 – 1473Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1071Substrate By similarity
Binding site1521Substrate By similarity
Binding site2711ATP By similarity
Binding site2751ATP By similarity

Amino acid modifications

Modified residue761Phosphoserine By similarity
Modified residue2051Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SZM9 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 575EC6F41FA4BA08

FASTA34437,268
        10         20         30         40         50         60 
MVTLYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDKCVERIN EMVNRAKRKA 

        70         80         90        100        110        120 
GVDPLVPLRG LGLSLSGGDQ EDAVRMLMEE LRDRFPYLSE SYLITTDAAG SIATATPDGG 

       130        140        150        160        170        180 
VVLISGTGSN CRLINPDGSE SGCGGWGHMM GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD 

       190        200        210        220        230        240 
IGYVKQAMFN YFQVPDRLGI LTHLYRDFDK SRFAGFCRKV AEGAQQGDPL SRCIFRKAGE 

       250        260        270        280        290        300 
MLGRHVVAVL PEIDPVLFQG EMGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNSFS 

       310        320        330        340 
GFTLLKLRHS SALGAASLGA KHIGHLLPMD YSTSAIAFYS YTFS 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102780 mRNA. Translation: AAI02781.1.
RefSeqNP_001029486.1. NM_001034314.2.
UniGeneBt.4387.

3D structure databases

ProteinModelPortalQ3SZM9.
SMRQ3SZM9. Positions 4-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000019528.

Proteomic databases

PRIDEQ3SZM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000019528; ENSBTAP00000019528; ENSBTAG00000014668.
GeneID508132.
KEGGbta:508132.

Organism-specific databases

CTD55577.

Phylogenomic databases

eggNOGCOG2971.
GeneTreeENSGT00510000047418.
HOGENOMHOG000007248.
HOVERGENHBG052570.
InParanoidQ3SZM9.
KOK00884.
OMAAFYSYTF.
OrthoDBEOG7V1FR7.
TreeFamTF314158.

Enzyme and pathway databases

UniPathwayUPA00629.

Family and domain databases

InterProIPR002731. ATPase_BadF.
[Graphical view]
PfamPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868366.

Entry information

Entry nameNAGK_BOVIN
AccessionPrimary (citable) accession number: Q3SZM9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways