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Q3SZM9 (NAGK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase
Short name=N-acetylglucosamine kinase
EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:NAGK
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has ManNAc kinase activity By similarity.

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

N-acetylglucosamine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344N-acetyl-D-glucosamine kinase
PRO_0000253473

Regions

Nucleotide binding6 – 138ATP By similarity
Region129 – 1302Substrate binding By similarity
Region145 – 1473Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1071Substrate By similarity
Binding site1521Substrate By similarity
Binding site2711ATP By similarity
Binding site2751ATP By similarity

Amino acid modifications

Modified residue761Phosphoserine By similarity
Modified residue2051Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SZM9 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 575EC6F41FA4BA08

FASTA34437,268
        10         20         30         40         50         60 
MVTLYGGVEG GGTRSKVLLL SEDGQILAEA DGLSTNHWLI GTDKCVERIN EMVNRAKRKA 

        70         80         90        100        110        120 
GVDPLVPLRG LGLSLSGGDQ EDAVRMLMEE LRDRFPYLSE SYLITTDAAG SIATATPDGG 

       130        140        150        160        170        180 
VVLISGTGSN CRLINPDGSE SGCGGWGHMM GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD 

       190        200        210        220        230        240 
IGYVKQAMFN YFQVPDRLGI LTHLYRDFDK SRFAGFCRKV AEGAQQGDPL SRCIFRKAGE 

       250        260        270        280        290        300 
MLGRHVVAVL PEIDPVLFQG EMGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNSFS 

       310        320        330        340 
GFTLLKLRHS SALGAASLGA KHIGHLLPMD YSTSAIAFYS YTFS

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102780 mRNA. Translation: AAI02781.1.
IPIIPI00718059.
RefSeqNP_001029486.1. NM_001034314.1.
UniGeneBt.4387.

3D structure databases

ProteinModelPortalQ3SZM9.
SMRQ3SZM9. Positions 4-344.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3SZM9.

Proteomic databases

PRIDEQ3SZM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000019528; ENSBTAP00000019528; ENSBTAG00000014668.
GeneID508132.
KEGGbta:508132.

Organism-specific databases

CTD55577.

Phylogenomic databases

eggNOGmaNOG15429.
GeneTreeENSGT00510000047418.
HOVERGENHBG052570.
InParanoidQ3SZM9.
OMARDRFPYL.
OrthoDBEOG4GF3FF.
PhylomeDBQ3SZM9.

Family and domain databases

InterProIPR002731. ATPase_BadF.
[Graphical view]
KOK00884.
PfamPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGK_BOVIN
AccessionPrimary (citable) accession number: Q3SZM9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 11, 2005
Last modified: November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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