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Q3SZM7

- DPEP1_BOVIN

UniProt

Q3SZM7 - DPEP1_BOVIN

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Protein
Dipeptidase 1
Gene
DPEP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity By similarity.

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Enzyme regulationi

Inhibited by L-penicillamine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Zinc 1; catalytic By similarity
Metal bindingi38 – 381Zinc 1; catalytic By similarity
Metal bindingi141 – 1411Zinc 1; catalytic By similarity
Metal bindingi141 – 1411Zinc 2; catalytic By similarity
Binding sitei168 – 1681Substrate By similarity
Metal bindingi214 – 2141Zinc 2; catalytic By similarity
Metal bindingi235 – 2351Zinc 2; catalytic By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei304 – 3041Substrate By similarity

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB
  2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  3. dipeptidyl-peptidase activity Source: InterPro
  4. metallodipeptidase activity Source: UniProtKB
  5. modified amino acid binding Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. antibiotic metabolic process Source: UniProtKB
  2. cellular response to calcium ion Source: UniProtKB
  3. cellular response to drug Source: UniProtKB
  4. cellular response to nitric oxide Source: UniProtKB
  5. homocysteine metabolic process Source: UniProtKB
  6. negative regulation of apoptotic process Source: UniProtKB
  7. negative regulation of cell migration Source: UniProtKB
  8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_215847. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Protein family/group databases

MEROPSiM19.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 1 (EC:3.4.13.19)
Alternative name(s):
Microsomal dipeptidase
Gene namesi
Name:DPEP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Apical cell membrane; Lipid-anchorGPI-anchor By similarity
Note: Brush border membrane By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. apical part of cell Source: UniProtKB
  3. apical plasma membrane Source: UniProtKB-SubCell
  4. extracellular space Source: UniProtKB
  5. extracellular vesicular exosome Source: Ensembl
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 By similarity
Add
BLAST
Chaini17 – 384368Dipeptidase 1
PRO_0000231601Add
BLAST
Propeptidei385 – 41026Removed in mature form By similarity
PRO_0000231602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) By similarity
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi87 ↔ 170 By similarity
Disulfide bondi242 ↔ 274 By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi377 – 377Interchain By similarity
Lipidationi384 – 3841GPI-anchor amidated serine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ3SZM7.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016201.

Structurei

3D structure databases

ProteinModelPortaliQ3SZM7.
SMRiQ3SZM7. Positions 17-384.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ3SZM7.
KOiK01273.
OMAiGMRYMTL.
OrthoDBiEOG7SJD4N.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZM7-1 [UniParc]FASTAAdd to Basket

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MWTGWWLWPL VAVCTADQFR DNAVRLMQST PVIDGHNDLP WQLLKRFNNQ    50
LQDPRANLTS LNGTHTNIPK LKAGFVGAQF WSAYTPCDTQ NKDSVKRTLE 100
QIDVIQRMCQ LYPETFLCVT DSAGIQQAFQ EGKVASLVGV EGGHSIDSSL 150
GVLRALYHLG MRYLTLTHSC NTPWADNWLV DTGEDEAQSQ GLSSFGQSVV 200
KEMNRLGVII DLAHVSVATM EAALQLSKAP VIFSHSSAYS VCRHRRNVPD 250
HVLQLVKQTG SLVMVNFYND YVSCKAEANL SQVADHLDYI KKVAGAGAVG 300
FGGDYDGVSR LPSGLEDVSK YPDLVAELLR RQWTEEEVRG ALAENLLRVF 350
KAVEQASDHK QAPGEEPIPL GQLEASCRTN YGYSGAPSLH LQPGTLLASL 400
VTLLLSLCLL 410
Length:410
Mass (Da):45,127
Last modified:October 11, 2005 - v1
Checksum:i25174E46E558F95D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102783 mRNA. Translation: AAI02784.1.
RefSeqiNP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.1.
XP_005218638.1. XM_005218581.1.
UniGeneiBt.48813.

Genome annotation databases

EnsembliENSBTAT00000016201; ENSBTAP00000016201; ENSBTAG00000033326.
GeneIDi514685.
KEGGibta:514685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102783 mRNA. Translation: AAI02784.1 .
RefSeqi NP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.1.
XP_005218638.1. XM_005218581.1.
UniGenei Bt.48813.

3D structure databases

ProteinModelPortali Q3SZM7.
SMRi Q3SZM7. Positions 17-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016201.

Protein family/group databases

MEROPSi M19.001.

Proteomic databases

PRIDEi Q3SZM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000016201 ; ENSBTAP00000016201 ; ENSBTAG00000033326 .
GeneIDi 514685.
KEGGi bta:514685.

Organism-specific databases

CTDi 1800.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q3SZM7.
KOi K01273.
OMAi GMRYMTL.
OrthoDBi EOG7SJD4N.
TreeFami TF324523.

Enzyme and pathway databases

Reactomei REACT_215847. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

NextBioi 20871464.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiDPEP1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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