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Protein

Dipeptidase 1

Gene

DPEP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi38Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei168SubstratePROSITE-ProRule annotation1
Metal bindingi214Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi235Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei246SubstratePROSITE-ProRule annotation1
Binding sitei304SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-BTA-5423646. Aflatoxin activation and detoxification.

Protein family/group databases

MEROPSiM19.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 1 (EC:3.4.13.19)
Alternative name(s):
Microsomal dipeptidase
Gene namesi
Name:DPEP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
ChainiPRO_000023160117 – 384Dipeptidase 1Add BLAST368
PropeptideiPRO_0000231602385 – 410Removed in mature formBy similarityAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)By similarity1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi377InterchainPROSITE-ProRule annotation
Lipidationi384GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ3SZM7.
PRIDEiQ3SZM7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000033326.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016201.

Structurei

3D structure databases

ProteinModelPortaliQ3SZM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ3SZM7.
KOiK01273.
OMAiGMRYMTL.
OrthoDBiEOG091G09CU.
TreeFamiTF324523.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTGWWLWPL VAVCTADQFR DNAVRLMQST PVIDGHNDLP WQLLKRFNNQ
60 70 80 90 100
LQDPRANLTS LNGTHTNIPK LKAGFVGAQF WSAYTPCDTQ NKDSVKRTLE
110 120 130 140 150
QIDVIQRMCQ LYPETFLCVT DSAGIQQAFQ EGKVASLVGV EGGHSIDSSL
160 170 180 190 200
GVLRALYHLG MRYLTLTHSC NTPWADNWLV DTGEDEAQSQ GLSSFGQSVV
210 220 230 240 250
KEMNRLGVII DLAHVSVATM EAALQLSKAP VIFSHSSAYS VCRHRRNVPD
260 270 280 290 300
HVLQLVKQTG SLVMVNFYND YVSCKAEANL SQVADHLDYI KKVAGAGAVG
310 320 330 340 350
FGGDYDGVSR LPSGLEDVSK YPDLVAELLR RQWTEEEVRG ALAENLLRVF
360 370 380 390 400
KAVEQASDHK QAPGEEPIPL GQLEASCRTN YGYSGAPSLH LQPGTLLASL
410
VTLLLSLCLL
Length:410
Mass (Da):45,127
Last modified:October 11, 2005 - v1
Checksum:i25174E46E558F95D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102783 mRNA. Translation: AAI02784.1.
RefSeqiNP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.3.
XP_005218638.1. XM_005218581.3.
UniGeneiBt.48813.

Genome annotation databases

EnsembliENSBTAT00000016201; ENSBTAP00000016201; ENSBTAG00000033326.
GeneIDi514685.
KEGGibta:514685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102783 mRNA. Translation: AAI02784.1.
RefSeqiNP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.3.
XP_005218638.1. XM_005218581.3.
UniGeneiBt.48813.

3D structure databases

ProteinModelPortaliQ3SZM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016201.

Protein family/group databases

MEROPSiM19.001.

Proteomic databases

PaxDbiQ3SZM7.
PRIDEiQ3SZM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016201; ENSBTAP00000016201; ENSBTAG00000033326.
GeneIDi514685.
KEGGibta:514685.

Organism-specific databases

CTDi1800.

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ3SZM7.
KOiK01273.
OMAiGMRYMTL.
OrthoDBiEOG091G09CU.
TreeFamiTF324523.

Enzyme and pathway databases

ReactomeiR-BTA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-BTA-5423646. Aflatoxin activation and detoxification.

Gene expression databases

BgeeiENSBTAG00000033326.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.