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Q3SZM7

- DPEP1_BOVIN

UniProt

Q3SZM7 - DPEP1_BOVIN

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Protein

Dipeptidase 1

Gene

DPEP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zinc.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi38 – 381Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi141 – 1411Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi141 – 1411Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei168 – 1681SubstratePROSITE-ProRule annotation
Metal bindingi214 – 2141Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi235 – 2351Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei246 – 2461SubstratePROSITE-ProRule annotation
Binding sitei304 – 3041SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  2. dipeptidyl-peptidase activity Source: InterPro
  3. GPI anchor binding Source: UniProtKB
  4. metallodipeptidase activity Source: UniProtKB
  5. modified amino acid binding Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. antibiotic metabolic process Source: UniProtKB
  2. cellular response to calcium ion Source: UniProtKB
  3. cellular response to drug Source: UniProtKB
  4. cellular response to nitric oxide Source: UniProtKB
  5. homocysteine metabolic process Source: UniProtKB
  6. negative regulation of apoptotic process Source: UniProtKB
  7. negative regulation of cell migration Source: UniProtKB
  8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_215847. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Protein family/group databases

MEROPSiM19.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 1 (EC:3.4.13.19)
Alternative name(s):
Microsomal dipeptidase
Gene namesi
Name:DPEP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Apical cell membrane By similarity; Lipid-anchorGPI-anchor By similarity
Note: Brush border membrane.By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. apical part of cell Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: Ensembl
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Chaini17 – 384368Dipeptidase 1PRO_0000231601Add
BLAST
Propeptidei385 – 41026Removed in mature formBy similarityPRO_0000231602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)By similarity
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi377 – 377InterchainPROSITE-ProRule annotation
Lipidationi384 – 3841GPI-anchor amidated serineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ3SZM7.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016201.

Structurei

3D structure databases

ProteinModelPortaliQ3SZM7.
SMRiQ3SZM7. Positions 17-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ3SZM7.
KOiK01273.
OMAiGMRYMTL.
OrthoDBiEOG7SJD4N.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWTGWWLWPL VAVCTADQFR DNAVRLMQST PVIDGHNDLP WQLLKRFNNQ
60 70 80 90 100
LQDPRANLTS LNGTHTNIPK LKAGFVGAQF WSAYTPCDTQ NKDSVKRTLE
110 120 130 140 150
QIDVIQRMCQ LYPETFLCVT DSAGIQQAFQ EGKVASLVGV EGGHSIDSSL
160 170 180 190 200
GVLRALYHLG MRYLTLTHSC NTPWADNWLV DTGEDEAQSQ GLSSFGQSVV
210 220 230 240 250
KEMNRLGVII DLAHVSVATM EAALQLSKAP VIFSHSSAYS VCRHRRNVPD
260 270 280 290 300
HVLQLVKQTG SLVMVNFYND YVSCKAEANL SQVADHLDYI KKVAGAGAVG
310 320 330 340 350
FGGDYDGVSR LPSGLEDVSK YPDLVAELLR RQWTEEEVRG ALAENLLRVF
360 370 380 390 400
KAVEQASDHK QAPGEEPIPL GQLEASCRTN YGYSGAPSLH LQPGTLLASL
410
VTLLLSLCLL
Length:410
Mass (Da):45,127
Last modified:October 11, 2005 - v1
Checksum:i25174E46E558F95D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102783 mRNA. Translation: AAI02784.1.
RefSeqiNP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.1.
XP_005218638.1. XM_005218581.1.
UniGeneiBt.48813.

Genome annotation databases

EnsembliENSBTAT00000016201; ENSBTAP00000016201; ENSBTAG00000033326.
GeneIDi514685.
KEGGibta:514685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102783 mRNA. Translation: AAI02784.1 .
RefSeqi NP_001029644.1. NM_001034472.2.
XP_005218637.1. XM_005218580.1.
XP_005218638.1. XM_005218581.1.
UniGenei Bt.48813.

3D structure databases

ProteinModelPortali Q3SZM7.
SMRi Q3SZM7. Positions 17-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016201.

Protein family/group databases

MEROPSi M19.002.

Proteomic databases

PRIDEi Q3SZM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000016201 ; ENSBTAP00000016201 ; ENSBTAG00000033326 .
GeneIDi 514685.
KEGGi bta:514685.

Organism-specific databases

CTDi 1800.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q3SZM7.
KOi K01273.
OMAi GMRYMTL.
OrthoDBi EOG7SJD4N.
TreeFami TF324523.

Enzyme and pathway databases

Reactomei REACT_215847. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

NextBioi 20871464.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028536. Dpep1.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF17. PTHR10443:SF17. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiDPEP1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3