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Protein

Angio-associated migratory cell protein

Gene

AAMP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell migration Source: UniProtKB
  • ribosomal large subunit biogenesis Source: GO_Central
  • smooth muscle cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angio-associated migratory cell protein
Gene namesi
Name:AAMP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Angio-associated migratory cell proteinPRO_0000278193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SZK1.
PRIDEiQ3SZK1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003927.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005126.

Structurei

3D structure databases

ProteinModelPortaliQ3SZK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 12941WD 1Add
BLAST
Repeati132 – 17140WD 2Add
BLAST
Repeati173 – 21240WD 3Add
BLAST
Repeati214 – 25441WD 4Add
BLAST
Repeati258 – 29942WD 5Add
BLAST
Repeati315 – 35440WD 6Add
BLAST
Repeati356 – 39540WD 7Add
BLAST
Repeati398 – 43336WD 8Add
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0296. Eukaryota.
ENOG410XR6A. LUCA.
GeneTreeiENSGT00760000119390.
HOGENOMiHOG000261676.
HOVERGENiHBG061307.
InParanoidiQ3SZK1.
OMAiQCGEFTP.
OrthoDBiEOG091G093C.
TreeFamiTF314543.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLVQEMEDV
60 70 80 90 100
DFEEEEEEEG NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD
110 120 130 140 150
PKTNTLAVTG GEDDKAFVWR LSDGELLFEC AGHKDSVTCA GFSHDSTLVA
160 170 180 190 200
TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM EWHPRAPVLL AGTADGNTWM
210 220 230 240 250
WKVPTGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR IWDLKQGNSI
260 270 280 290 300
HVLKGTEGHQ GPLTCVATNQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
310 320 330 340 350
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLSTQT
360 370 380 390 400
LRHQCQHQSG IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT
410 420 430
AEILDFALSK DASLVVTTSG DHKAKVFCVQ RPDR
Length:434
Mass (Da):46,829
Last modified:October 11, 2005 - v1
Checksum:iA30C5979D7A8DCC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102815 mRNA. Translation: AAI02816.1.
RefSeqiNP_001070463.1. NM_001076995.2.
UniGeneiBt.20293.

Genome annotation databases

EnsembliENSBTAT00000005126; ENSBTAP00000005126; ENSBTAG00000003927.
GeneIDi767919.
KEGGibta:767919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102815 mRNA. Translation: AAI02816.1.
RefSeqiNP_001070463.1. NM_001076995.2.
UniGeneiBt.20293.

3D structure databases

ProteinModelPortaliQ3SZK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005126.

Proteomic databases

PaxDbiQ3SZK1.
PRIDEiQ3SZK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005126; ENSBTAP00000005126; ENSBTAG00000003927.
GeneIDi767919.
KEGGibta:767919.

Organism-specific databases

CTDi14.

Phylogenomic databases

eggNOGiKOG0296. Eukaryota.
ENOG410XR6A. LUCA.
GeneTreeiENSGT00760000119390.
HOGENOMiHOG000261676.
HOVERGENiHBG061307.
InParanoidiQ3SZK1.
OMAiQCGEFTP.
OrthoDBiEOG091G093C.
TreeFamiTF314543.

Gene expression databases

BgeeiENSBTAG00000003927.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAMP_BOVIN
AccessioniPrimary (citable) accession number: Q3SZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.