ID   PMM2_BOVIN              Reviewed;         246 AA.
AC   Q3SZJ9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Phosphomannomutase 2;
DE            Short=PMM 2;
DE            EC=5.4.2.8;
GN   Name=PMM2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the synthesis of the GDP-mannose and
CC       dolichol-phosphate-mannose required for a number of critical
CC       mannosyl transfer reactions (By similarity).
CC   -!- CATALYTIC ACTIVITY: Alpha-D-mannose 1-phosphate = D-mannose 6-
CC       phosphate.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-D-mannose
CC       biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC       phosphate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the eukaryotic PMM family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC102817; AAI02818.1; -; mRNA.
DR   IPI; IPI00689323; -.
DR   RefSeq; NP_001030267.1; -.
DR   UniGene; Bt.63538; -.
DR   Ensembl; ENSBTAG00000001440; Bos taurus.
DR   GeneID; 510978; -.
DR   KEGG; bta:510978; -.
DR   HOVERGEN; Q3SZJ9; -.
DR   OMA; Q3SZJ9; LLCKQNI.
DR   BRENDA; 5.4.2.8; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004615; F:phosphomannomutase activity; IEA:EC.
DR   GO; GO:0019307; P:mannose biosynthetic process; IEA:InterPro.
DR   InterPro; IPR006379; HAD-SF_hydro_IIB.
DR   InterPro; IPR005002; PMM.
DR   PANTHER; PTHR10466; PMM; 1.
DR   Pfam; PF03332; PMM; 1.
DR   TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Isomerase.
FT   CHAIN         1    246       Phosphomannomutase 2.
FT                                /FTId=PRO_0000239734.
SQ   SEQUENCE   246 AA;  27997 MW;  A1F430A34A2E5118 CRC64;
     MAAPGPALCL FDVDGTLTAP RQKITKDMDC FLQKLRQKIK IGVVGGSDFE KVQEQLGDDV
     IKKYDYVFPE NGLVAYRDGK LLCKQNIQGH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI
     EFRNGMLNVS PIGRSCSQEE RIEFYELDQK ENIRQKFVED LRKEFAGKGL TFSIGGQISF
     DVFPDGWDKR YCLGHVEKDG YKTIYFFGDK TMPGGNDHEI FTDPRTVGYT VAAPEDTRRI
     CEELFC
//