Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphomannomutase 2

Gene

PMM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121NucleophileBy similarity
Active sitei14 – 141Proton donor/acceptorSequence Analysis
Binding sitei21 – 211SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei134 – 1341SubstrateBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_203476. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:PMM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 246245Phosphomannomutase 2PRO_0000239734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ3SZJ9.

Expressioni

Gene expression databases

ExpressionAtlasiQ3SZJ9. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001888.

Structurei

3D structure databases

ProteinModelPortaliQ3SZJ9.
SMRiQ3SZJ9. Positions 4-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ3SZJ9.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.
TreeFamiTF300874.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPGPALCL FDVDGTLTAP RQKITKDMDC FLQKLRQKIK IGVVGGSDFE
60 70 80 90 100
KVQEQLGDDV IKKYDYVFPE NGLVAYRDGK LLCKQNIQGH LGEALIQDLI
110 120 130 140 150
NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDQK
160 170 180 190 200
ENIRQKFVED LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLGHVEKDG
210 220 230 240
YKTIYFFGDK TMPGGNDHEI FTDPRTVGYT VAAPEDTRRI CEELFC
Length:246
Mass (Da):27,997
Last modified:October 11, 2005 - v1
Checksum:iA1F430A34A2E5118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102817 mRNA. Translation: AAI02818.1.
RefSeqiNP_001030267.1. NM_001035095.2.
UniGeneiBt.63538.

Genome annotation databases

EnsembliENSBTAT00000001888; ENSBTAP00000001888; ENSBTAG00000001440.
GeneIDi510978.
KEGGibta:510978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102817 mRNA. Translation: AAI02818.1.
RefSeqiNP_001030267.1. NM_001035095.2.
UniGeneiBt.63538.

3D structure databases

ProteinModelPortaliQ3SZJ9.
SMRiQ3SZJ9. Positions 4-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001888.

Proteomic databases

PRIDEiQ3SZJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001888; ENSBTAP00000001888; ENSBTAG00000001440.
GeneIDi510978.
KEGGibta:510978.

Organism-specific databases

CTDi5373.

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ3SZJ9.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.
TreeFamiTF300874.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiREACT_203476. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi20869710.

Gene expression databases

ExpressionAtlasiQ3SZJ9. baseline.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPMM2_BOVIN
AccessioniPrimary (citable) accession number: Q3SZJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.