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Q3SZJ9 (PMM2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase 2

Short name=PMM 2
EC=5.4.2.8
Gene names
Name:PMM2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic PMM family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

mannose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 246245Phosphomannomutase 2
PRO_0000239734

Sites

Active site121Nucleophile By similarity
Active site141Proton donor/acceptor Potential
Binding site211Substrate By similarity
Binding site1231Substrate By similarity
Binding site1341Substrate By similarity
Binding site1411Substrate By similarity
Binding site1791Substrate By similarity
Binding site1811Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SZJ9 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: A1F430A34A2E5118

FASTA24627,997
        10         20         30         40         50         60 
MAAPGPALCL FDVDGTLTAP RQKITKDMDC FLQKLRQKIK IGVVGGSDFE KVQEQLGDDV 

        70         80         90        100        110        120 
IKKYDYVFPE NGLVAYRDGK LLCKQNIQGH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI 

       130        140        150        160        170        180 
EFRNGMLNVS PIGRSCSQEE RIEFYELDQK ENIRQKFVED LRKEFAGKGL TFSIGGQISF 

       190        200        210        220        230        240 
DVFPDGWDKR YCLGHVEKDG YKTIYFFGDK TMPGGNDHEI FTDPRTVGYT VAAPEDTRRI 


CEELFC 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102817 mRNA. Translation: AAI02818.1.
RefSeqNP_001030267.1. NM_001035095.2.
UniGeneBt.63538.

3D structure databases

ProteinModelPortalQ3SZJ9.
SMRQ3SZJ9. Positions 4-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001888.

Proteomic databases

PRIDEQ3SZJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001888; ENSBTAP00000001888; ENSBTAG00000001440.
GeneID510978.
KEGGbta:510978.

Organism-specific databases

CTD5373.

Phylogenomic databases

eggNOGCOG0561.
GeneTreeENSGT00390000002918.
HOGENOMHOG000181843.
HOVERGENHBG009971.
InParanoidQ3SZJ9.
KOK17497.
OMATYCLQHV.
OrthoDBEOG773XH0.
TreeFamTF300874.

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERPTHR10466. PTHR10466. 1 hit.
PfamPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetSearch...

Other

NextBio20869710.

Entry information

Entry namePMM2_BOVIN
AccessionPrimary (citable) accession number: Q3SZJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways