Reviewed, UniProtKB/Swiss-Prot Q3SZJ9 (PMM2_BOVIN)

Names and origin

Protein names

Recommended name:
    Phosphomannomutase 2
      Short name=PMM 2
    EC=5.4.2.8

Gene names

Name:

PMM2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Pathway	Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic PMM family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	mannose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Phosphomannomutase 2		PRO_0000239734

Sequences

	Sequence		Length	Mass (Da)
	Q3SZJ9-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A1F430A34A2E5118	FASTA	246	27,997
	10 20 30 40 50 60 MAAPGPALCL FDVDGTLTAP RQKITKDMDC FLQKLRQKIK IGVVGGSDFE KVQEQLGDDV 70 80 90 100 110 120 IKKYDYVFPE NGLVAYRDGK LLCKQNIQGH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI 130 140 150 160 170 180 EFRNGMLNVS PIGRSCSQEE RIEFYELDQK ENIRQKFVED LRKEFAGKGL TFSIGGQISF 190 200 210 220 230 240 DVFPDGWDKR YCLGHVEKDG YKTIYFFGDK TMPGGNDHEI FTDPRTVGYT VAAPEDTRRI CEELFC

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102817 mRNA. Translation: AAI02818.1.
IPI	IPI00689323.
RefSeq	NP_001030267.1.
UniGene	Bt.63538
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000001440. Bos taurus. [Contig view]
GeneID	510978.
KEGG	bta:510978.
Phylogenomic databases
HOVERGEN	Q3SZJ9.
OMA	Q3SZJ9. LLCKQNI.
Enzyme and pathway databases
BRENDA	5.4.2.8. 251.
Family and domain databases
InterPro	IPR006379. HAD-SF_hydro_IIB. IPR005002. PMM. [Graphical view]
PANTHER	PTHR10466. PMM. 1 hit.
Pfam	PF03332. PMM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PMM2_BOVIN

Accession

Primary (citable) accession number: Q3SZJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)