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Protein

Phosphomannomutase 2

Gene

PMM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (MPI), Mannose-6-phosphate isomerase (MPI)
  2. Phosphomannomutase (PMM2), Phosphomannomutase 2 (PMM2), Phosphomannomutase (PMM1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12NucleophileBy similarity1
Active sitei14Proton donor/acceptorSequence analysis1
Binding sitei21SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei134SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-BTA-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:PMM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002397342 – 246Phosphomannomutase 2Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZJ9.
PRIDEiQ3SZJ9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001440.
ExpressionAtlasiQ3SZJ9. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001888.

Structurei

3D structure databases

ProteinModelPortaliQ3SZJ9.
SMRiQ3SZJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ3SZJ9.
KOiK17497.
OMAiFDYCFSE.
OrthoDBiEOG091G0J2S.
TreeFamiTF300874.

Family and domain databases

CDDicd02585. HAD_PMM. 1 hit.
Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR036412. HAD-like_sf.
IPR006379. HAD-SF_hydro_IIB.
IPR023214. HAD_sf.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGPALCL FDVDGTLTAP RQKITKDMDC FLQKLRQKIK IGVVGGSDFE
60 70 80 90 100
KVQEQLGDDV IKKYDYVFPE NGLVAYRDGK LLCKQNIQGH LGEALIQDLI
110 120 130 140 150
NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDQK
160 170 180 190 200
ENIRQKFVED LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLGHVEKDG
210 220 230 240
YKTIYFFGDK TMPGGNDHEI FTDPRTVGYT VAAPEDTRRI CEELFC
Length:246
Mass (Da):27,997
Last modified:October 11, 2005 - v1
Checksum:iA1F430A34A2E5118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102817 mRNA. Translation: AAI02818.1.
RefSeqiNP_001030267.1. NM_001035095.2.
UniGeneiBt.63538.

Genome annotation databases

EnsembliENSBTAT00000001888; ENSBTAP00000001888; ENSBTAG00000001440.
GeneIDi510978.
KEGGibta:510978.

Similar proteinsi

Entry informationi

Entry nameiPMM2_BOVIN
AccessioniPrimary (citable) accession number: Q3SZJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families