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Protein

Transcription factor GATA-5

Gene

GATA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 218GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-5
Alternative name(s):
GATA-binding factor 5
Gene namesi
Name:GATA5By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895891 – 403Transcription factor GATA-5Add BLAST403

Proteomic databases

PaxDbiQ3SZJ5.
PRIDEiQ3SZJ5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000047944.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027184.

Structurei

3D structure databases

ProteinModelPortaliQ3SZJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 218GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ3SZJ5.
KOiK17896.
OMAiWTAGPFD.
OrthoDBiEOG091G0AUR.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028372. TF_GATA-5.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF193. PTHR10071:SF193. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQSLALAPS PGQTAYADSG AFLHTPGAGS PVFVPPARVP SMLPYLPACE
60 70 80 90 100
PGPQAPAITA HPGWAQAAAA DSSAFGSGSP HAPAAPPPGT TAFPFAHSSP
110 120 130 140 150
GPGGGTGTRD NGAFQGAMLA REQYPAALGR PVSSSYPTAY PAYMSAEVAP
160 170 180 190 200
SWTSGPLDGS VLHSLQGLPA GLPGRRAPFA AELLEEFPGE GRECVNCGAL
210 220 230 240 250
STPLWRRDGT GHYLCNACGL YHKMNGVNRP LVRPQKRLSS SRRAGLCCTN
260 270 280 290 300
CHTTTTTLWR RNVDGEPVCN ACGLYMKLHG VPRPLAMKKE SIQTRKRKPK
310 320 330 340 350
NIAKTKGSSG SSGHTTASPQ ASVPDPEVSA ATLKPEPSLA SPSCPGPSVT
360 370 380 390 400
SQGSAQVDDP LAPSHLEFKF EPEDFALPSA ALGQQAGLGG ALRQEAWCAL

ALA
Length:403
Mass (Da):41,603
Last modified:October 11, 2005 - v1
Checksum:iBCEB21845BBE7955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102821 mRNA. Translation: AAI02822.1.
RefSeqiNP_001029393.1. NM_001034221.2.
UniGeneiBt.61958.

Genome annotation databases

EnsembliENSBTAT00000027184; ENSBTAP00000027184; ENSBTAG00000047944.
GeneIDi504784.
KEGGibta:504784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102821 mRNA. Translation: AAI02822.1.
RefSeqiNP_001029393.1. NM_001034221.2.
UniGeneiBt.61958.

3D structure databases

ProteinModelPortaliQ3SZJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027184.

Proteomic databases

PaxDbiQ3SZJ5.
PRIDEiQ3SZJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027184; ENSBTAP00000027184; ENSBTAG00000047944.
GeneIDi504784.
KEGGibta:504784.

Organism-specific databases

CTDi140628.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiQ3SZJ5.
KOiK17896.
OMAiWTAGPFD.
OrthoDBiEOG091G0AUR.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiR-BTA-983231. Factors involved in megakaryocyte development and platelet production.

Gene expression databases

BgeeiENSBTAG00000047944.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028372. TF_GATA-5.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF193. PTHR10071:SF193. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA5_BOVIN
AccessioniPrimary (citable) accession number: Q3SZJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.