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Protein

Transcription factor GATA-5

Gene

GATA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 218GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-5
Alternative name(s):
GATA-binding factor 5
Gene namesi
Name:GATA5By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:29269 GATA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895891 – 403Transcription factor GATA-5Add BLAST403

Proteomic databases

PaxDbiQ3SZJ5
PRIDEiQ3SZJ5

Expressioni

Gene expression databases

BgeeiENSBTAG00000047944

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027184

Structurei

3D structure databases

ProteinModelPortaliQ3SZJ5
SMRiQ3SZJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri194 – 218GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiQ3SZJ5
KOiK17896
OMAiAFPFAHS
OrthoDBiEOG091G0AUR
TreeFamiTF315391

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q3SZJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQSLALAPS PGQTAYADSG AFLHTPGAGS PVFVPPARVP SMLPYLPACE
60 70 80 90 100
PGPQAPAITA HPGWAQAAAA DSSAFGSGSP HAPAAPPPGT TAFPFAHSSP
110 120 130 140 150
GPGGGTGTRD NGAFQGAMLA REQYPAALGR PVSSSYPTAY PAYMSAEVAP
160 170 180 190 200
SWTSGPLDGS VLHSLQGLPA GLPGRRAPFA AELLEEFPGE GRECVNCGAL
210 220 230 240 250
STPLWRRDGT GHYLCNACGL YHKMNGVNRP LVRPQKRLSS SRRAGLCCTN
260 270 280 290 300
CHTTTTTLWR RNVDGEPVCN ACGLYMKLHG VPRPLAMKKE SIQTRKRKPK
310 320 330 340 350
NIAKTKGSSG SSGHTTASPQ ASVPDPEVSA ATLKPEPSLA SPSCPGPSVT
360 370 380 390 400
SQGSAQVDDP LAPSHLEFKF EPEDFALPSA ALGQQAGLGG ALRQEAWCAL

ALA
Length:403
Mass (Da):41,603
Last modified:October 11, 2005 - v1
Checksum:iBCEB21845BBE7955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102821 mRNA Translation: AAI02822.1
RefSeqiNP_001029393.1, NM_001034221.2
UniGeneiBt.61958

Genome annotation databases

EnsembliENSBTAT00000027184; ENSBTAP00000027184; ENSBTAG00000047944
GeneIDi504784
KEGGibta:504784

Similar proteinsi

Entry informationi

Entry nameiGATA5_BOVIN
AccessioniPrimary (citable) accession number: Q3SZJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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