ID   ARLY_BOVIN              Reviewed;         473 AA.
AC   Q3SZJ0;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Argininosuccinate lyase;
DE            Short=ASAL;
DE            EC=4.3.2.1;
DE   AltName: Full=Arginosuccinase;
GN   Name=ASL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2-(N(omega)-L-arginino)succinate = fumarate +
CC       L-arginine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 3/3.
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; L-arginine and fumarate
CC       from N(omega)-(L-arginino)succinic acid: step 1/1.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily.
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DR   EMBL; BC102831; AAI02832.1; -; mRNA.
DR   IPI; IPI00703946; -.
DR   RefSeq; NP_001029600.1; -.
DR   UniGene; Bt.10013; -.
DR   SMR; Q3SZJ0; 16-465.
DR   Ensembl; ENSBTAG00000015314; Bos taurus.
DR   GeneID; 512771; -.
DR   KEGG; bta:512771; -.
DR   HOVERGEN; Q3SZJ0; -.
DR   BRENDA; 4.3.2.1; 251.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:EC.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   GO; GO:0000050; P:urea cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR003031; D_crystallin.
DR   InterPro; IPR000362; Fumarate_lyase.
DR   PANTHER; PTHR11444:SF3; argH; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; DCRYSTALLIN.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Lyase; Urea cycle.
FT   CHAIN         1    473       Argininosuccinate lyase.
FT                                /FTId=PRO_0000273253.
SQ   SEQUENCE   473 AA;  52743 MW;  DCF05530CFB06404 CRC64;
     MASESGKLWG GRFVGTVDPI MEKFNSSITY DRHLWEADVQ GSKAYSRGLE KAGLLTKAEM
     DQILHGLDKV AEEWAQGTFK LNPNDEDIHT ANERRLKELI GETAGKLHTG RSRNDQVVTD
     LRLWMRQNCS MLSALLCELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL
     TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL DFGAITLNSM DATSERDFVA
     EFLFWASLCM THLSRMAEDL ILYGTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA
     GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHRENM
     GRALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF
     SGDVSHVWDY GHSVEQYEAL GGTARSSVDW QIGQLRALLR AQQTESPPHA SPK
//