ID   IVD_BOVIN               Reviewed;         426 AA.
AC   Q3SZI8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial;
DE            Short=IVD;
DE            EC=1.3.99.10;
DE   Flags: Precursor;
GN   Name=IVD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-
CC       2-enoyl-CoA + reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; HMG-CoA
CC       from 3-isovaleryl-CoA: step 1/3.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR   EMBL; BC102836; AAI02837.1; -; mRNA.
DR   IPI; IPI00691032; -.
DR   RefSeq; NP_001029554.1; -.
DR   UniGene; Bt.49071; -.
DR   SMR; Q3SZI8; 38-424.
DR   Ensembl; ENSBTAG00000004409; Bos taurus.
DR   GeneID; 510440; -.
DR   KEGG; bta:510440; -.
DR   HOVERGEN; Q3SZI8; -.
DR   OMA; Q3SZI8; ELFNETR.
DR   BRENDA; 1.3.99.10; 251.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006089; Acyl-CoA_DH_CS.
DR   InterPro; IPR006092; Acyl-CoA_DH_N.
DR   InterPro; IPR006090; Acyl-CoA_Oxase/DH_1.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_M.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR   PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Transit peptide.
FT   TRANSIT       1     32       Mitochondrion (By similarity).
FT   CHAIN        33    426       Isovaleryl-CoA dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000281993.
FT   ACT_SITE    286    286       Proton acceptor (By similarity).
FT   MOD_RES      78     78       N6-acetyllysine (By similarity).
SQ   SEQUENCE   426 AA;  46498 MW;  77C268E25568ACCA CRC64;
     MATAAWLLGR RVASWRMRPP LQSLAGLITQ RTNSLLPVDD AVNGLNEEQK QLRQTVAKFL
     QEHLAPQAQE IDQSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGFLE NVLVMEEISR
     VSGAVGLSYG AHSNLCINQI VRNGNETQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK
     LKAEKKGDHY VLNGNKFWIT NGPDADVLVV YAKTDVTAVP ASRGITAFIV EKGMPGFSTS
     KKLDKLGMRG SNTCELVFED CEVPAANILG HLGKGVYVLM SGLDLERLVL AGGPLGIMQA
     VLDHTIPYLH MREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTTKDC
     AGVILYSAEC ATQVALDGIQ CLGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA
     FNADFH
//