Reviewed, UniProtKB/Swiss-Prot Q3SZI8 (IVD_BOVIN)

Names and origin

Protein names

Recommended name:
    Isovaleryl-CoA dehydrogenase, mitochondrial
      Short name=IVD
    EC=1.3.99.10

Gene names

Name:

IVD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro isovaleryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 32	32	Mitochondrion By similarity
	Chain	33 – 426	394	Isovaleryl-CoA dehydrogenase, mitochondrial		PRO_0000281993
Regions
	Nucleotide binding	165 – 174	10	FAD By similarity
	Nucleotide binding	198 – 200	3	FAD By similarity
	Nucleotide binding	380 – 384	5	FAD By similarity
	Nucleotide binding	409 – 411	3	FAD By similarity
	Region	222 – 223	2	Substrate binding By similarity
	Region	284 – 287	4	Substrate binding By similarity
	Region	407 – 408	2	Substrate binding By similarity
Sites
	Active site	286	1	Proton acceptor By similarity
	Binding site	174	1	Substrate; via carbonyl oxygen By similarity
	Binding site	277	1	Substrate By similarity
	Binding site	312	1	FAD By similarity
	Binding site	323	1	FAD By similarity
Amino acid modifications
	Modified residue	78	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZI8-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 77C268E25568ACCA	FASTA	426	46,498
	10 20 30 40 50 60 MATAAWLLGR RVASWRMRPP LQSLAGLITQ RTNSLLPVDD AVNGLNEEQK QLRQTVAKFL 70 80 90 100 110 120 QEHLAPQAQE IDQSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGFLE NVLVMEEISR 130 140 150 160 170 180 VSGAVGLSYG AHSNLCINQI VRNGNETQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK 190 200 210 220 230 240 LKAEKKGDHY VLNGNKFWIT NGPDADVLVV YAKTDVTAVP ASRGITAFIV EKGMPGFSTS 250 260 270 280 290 300 KKLDKLGMRG SNTCELVFED CEVPAANILG HLGKGVYVLM SGLDLERLVL AGGPLGIMQA 310 320 330 340 350 360 VLDHTIPYLH MREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTTKDC 370 380 390 400 410 420 AGVILYSAEC ATQVALDGIQ CLGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA FNADFH

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102836 mRNA. Translation: AAI02837.1.
IPI	IPI00691032.
RefSeq	NP_001029554.1.
UniGene	Bt.49071
3D structure databases
HSSP	HSSP built from PDB template 1WS9 based on UniProtKB Q5SGZ2.
SMR	Q3SZI8. Positions 38-424.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SZI8.
Genome annotation databases
Ensembl	ENSBTAT00000005782; ENSBTAP00000005782; ENSBTAG00000004409; Bos taurus. [Genome view]
GeneID	510440.
KEGG	bta:510440.
Organism-specific databases
CTD	510440.
Phylogenomic databases
eggNOG	maNOG11520.
HOVERGEN	Q3SZI8.
InParanoid	Q3SZI8.
OMA	MYVTMNA.
OrthoDB	EOG9FFGM4.
Enzyme and pathway databases
BRENDA	1.3.99.10. 251.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IVD_BOVIN

Accession

Primary (citable) accession number: Q3SZI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 11, 2005
Last modified:	January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)