ID   MPI_BOVIN               Reviewed;         423 AA.
AC   Q3SZI0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Mannose-6-phosphate isomerase;
DE            EC=5.3.1.8;
DE   AltName: Full=Phosphomannose isomerase;
DE            Short=PMI;
DE   AltName: Full=Phosphohexomutase;
GN   Name=MPI;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the synthesis of the GDP-mannose and
CC       dolichol-phosphate-mannose required for a number of critical
CC       mannosyl transfer reactions (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC       phosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-D-mannose
CC       biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC       phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC       family.
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DR   EMBL; BC102844; AAI02845.1; -; mRNA.
DR   IPI; IPI00692165; -.
DR   RefSeq; NP_001030361.1; -.
DR   UniGene; Bt.48873; -.
DR   Ensembl; ENSBTAG00000005845; Bos taurus.
DR   GeneID; 513586; -.
DR   KEGG; bta:513586; -.
DR   HOVERGEN; Q3SZI0; -.
DR   BRENDA; 5.3.1.8; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR001250; Man6P_Isoase-1.
DR   InterPro; IPR016305; Mannose-6-P_Isomerase.
DR   InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Gene3D; G3DSA:2.60.120.10; RmlC-like_jellyroll; 2.
DR   Pfam; PF01238; PMI_typeI; 1.
DR   PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR   PRINTS; PR00714; MAN6PISMRASE.
DR   TIGRFAMs; TIGR00218; manA; 1.
DR   PROSITE; PS00965; PMI_I_1; 1.
DR   PROSITE; PS00966; PMI_I_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Isomerase; Metal-binding; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    423       Mannose-6-phosphate isomerase.
FT                                /FTId=PRO_0000245030.
FT   ACT_SITE    295    295       By similarity.
FT   METAL       110    110       Zinc (By similarity).
FT   METAL       112    112       Zinc (By similarity).
FT   METAL       137    137       Zinc (By similarity).
FT   METAL       276    276       Zinc (By similarity).
SQ   SEQUENCE   423 AA;  46369 MW;  9BE8AB8D3B8B37E5 CRC64;
     MAAQRVFPLS CVVQQYAWGK MGSNSEVARL LASSDPLAQI SEDRPYAELW MGTHPRGDAK
     ILDNRISQKT LGQWIADNQD SLGSKVKDTF NGKLPFLFKV LSVETALSIQ AHPNKELAEK
     LHLQAPQHYP DANHKPEMAI ALTPFQGLCG FRPVEEIVTF LTKVPEFQFL IGDNAAAQLK
     QSLSQDSEAV TSALRSCFSH LMKSEKKVVV EQLNLLVKRI SQQVAAGNNM EDICGELLLQ
     LHQQYPGDIG CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP
     KFIDVPTLCE MLSYTPSPSQ DRLFPPARSP EDPYLSIYDP PVPDFTVMKV EVPGSVTEYK
     VLALDSASIL LVVQGTVTAS SPTAQAAIPL KRGGVLFIGA NESVSLKLTV PKDLLMFRAC
     CLL
//