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Q3SZI0

- MPI_BOVIN

UniProt

Q3SZI0 - MPI_BOVIN

Protein

Mannose-6-phosphate isomerase

Gene

MPI

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi110 – 1101ZincBy similarity
    Metal bindingi112 – 1121ZincBy similarity
    Metal bindingi137 – 1371ZincBy similarity
    Metal bindingi276 – 2761ZincBy similarity
    Active sitei295 – 2951By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00423.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:MPI
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 423422Mannose-6-phosphate isomerasePRO_0000245030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ3SZI0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000043605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SZI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    HOGENOMiHOG000241277.
    HOVERGENiHBG000367.
    InParanoidiQ3SZI0.
    KOiK01809.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SZI0-1 [UniParc]FASTAAdd to Basket

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    MAAQRVFPLS CVVQQYAWGK MGSNSEVARL LASSDPLAQI SEDRPYAELW    50
    MGTHPRGDAK ILDNRISQKT LGQWIADNQD SLGSKVKDTF NGKLPFLFKV 100
    LSVETALSIQ AHPNKELAEK LHLQAPQHYP DANHKPEMAI ALTPFQGLCG 150
    FRPVEEIVTF LTKVPEFQFL IGDNAAAQLK QSLSQDSEAV TSALRSCFSH 200
    LMKSEKKVVV EQLNLLVKRI SQQVAAGNNM EDICGELLLQ LHQQYPGDIG 250
    CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP 300
    KFIDVPTLCE MLSYTPSPSQ DRLFPPARSP EDPYLSIYDP PVPDFTVMKV 350
    EVPGSVTEYK VLALDSASIL LVVQGTVTAS SPTAQAAIPL KRGGVLFIGA 400
    NESVSLKLTV PKDLLMFRAC CLL 423
    Length:423
    Mass (Da):46,369
    Last modified:January 23, 2007 - v3
    Checksum:i9BE8AB8D3B8B37E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102844 mRNA. Translation: AAI02845.1.
    RefSeqiNP_001030361.1. NM_001035284.1.
    UniGeneiBt.48873.

    Genome annotation databases

    GeneIDi513586.
    KEGGibta:513586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102844 mRNA. Translation: AAI02845.1 .
    RefSeqi NP_001030361.1. NM_001035284.1.
    UniGenei Bt.48873.

    3D structure databases

    ProteinModelPortali Q3SZI0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000043605.

    Proteomic databases

    PRIDEi Q3SZI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 513586.
    KEGGi bta:513586.

    Organism-specific databases

    CTDi 4351.

    Phylogenomic databases

    eggNOGi COG1482.
    HOGENOMi HOG000241277.
    HOVERGENi HBG000367.
    InParanoidi Q3SZI0.
    KOi K01809.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .

    Miscellaneous databases

    NextBioi 20870929.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiMPI_BOVIN
    AccessioniPrimary (citable) accession number: Q3SZI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3