Reviewed,
UniProtKB/Swiss-Prot Q3SZI0 (MPI_BOVIN)
Last modified
June 16, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannose-6-phosphate isomerase EC=5.3.1.8 Alternative name(s): Phosphomannose isomerase Short name=PMI Phosphohexomutase | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 423 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity. |
| Catalytic activity | D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the mannose-6-phosphate isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding Zinc |
| Molecular function | Isomerase |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 423 | 422 | Mannose-6-phosphate isomerase | PRO_0000245030 | |||||
Sites | |||||||||
| Active site | 295 | 1 | By similarity | ||||||
| Metal binding | 110 | 1 | Zinc By similarity | ||||||
| Metal binding | 112 | 1 | Zinc By similarity | ||||||
| Metal binding | 137 | 1 | Zinc By similarity | ||||||
| Metal binding | 276 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| BC102844 mRNA. Translation: AAI02845.1. | |
| IPI | IPI00692165. |
| RefSeq | NP_001030361.1. |
| UniGene | Bt.48873 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000005845. Bos taurus. [Contig view] |
| GeneID | 513586. |
| KEGG | bta:513586. |
Phylogenomic databases | |
| HOVERGEN | Q3SZI0. |
Enzyme and pathway databases | |
| BRENDA | 5.3.1.8. 251. |
Family and domain databases | |
| InterPro | IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits. |
| Pfam | PF01238. PMI_typeI. 1 hit. [Graphical view] |
| PIRSF | PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit. |
| PRINTS | PR00714. MAN6PISMRASE. |
| TIGRFAMs | TIGR00218. manA. 1 hit. |
| PROSITE | PS00965. PMI_I_1. 1 hit. PS00966. PMI_I_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPI_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3SZI0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


