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Protein

Tubulin-specific chaperone C

Gene

TBCC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin-folding protein; involved in the final step of the tubulin folding pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-BTA-389977. Post-chaperonin tubulin folding pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone C
Alternative name(s):
Tubulin-folding cofactor C
Short name:
CFC
Gene namesi
Name:TBCC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851061 – 345Tubulin-specific chaperone CAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SZE9.
PRIDEiQ3SZE9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000940.

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001245.

Structurei

3D structure databases

ProteinModelPortaliQ3SZE9.
SMRiQ3SZE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 322C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Belongs to the TBCC family.Curated

Phylogenomic databases

eggNOGiKOG2512. Eukaryota.
ENOG410Y28B. LUCA.
GeneTreeiENSGT00530000063741.
HOGENOMiHOG000030935.
HOVERGENiHBG017893.
InParanoidiQ3SZE9.
KOiK21766.
OMAiCQQLRLH.
OrthoDBiEOG091G0K00.
TreeFamiTF105832.

Family and domain databases

InterProiView protein in InterPro
IPR017901. C-CAP_CF_C-like.
IPR006599. CARP_motif.
IPR027684. TBCC.
IPR031925. TBCC_N.
IPR012945. Tubulin-bd_cofactor_C_dom.
PANTHERiPTHR15139. PTHR15139. 1 hit.
PfamiView protein in Pfam
PF07986. TBCC. 1 hit.
PF16752. TBCC_N. 1 hit.
PIRSFiPIRSF037947. Protein_XRP2_. 1 hit.
SMARTiView protein in SMART
SM00673. CARP. 2 hits.
PROSITEiView protein in PROSITE
PS51329. C_CAP_COFACTOR_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SZE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGGLSAAA LANGDLGSQR ERTLVPERLQ KREHERQLEV ERRKQKRQDQ
60 70 80 90 100
EVEEEKSDFF AAAFARERSA VEELLESGES VERLEEAAAR LQGLQKLIND
110 120 130 140 150
SVLFLAAYDL RQAQEVLARL QAALAKRRQE LQPKKRFAFK TRKKDAASAT
160 170 180 190 200
QVASAPDAPA AEGSLTSPPP LKEEGDFDSS WICGFSNLQS QVLEKRAEEL
210 220 230 240 250
HQQDVLLTQL RNCTIKLYGN PNTLRLTKAQ GCTLLCGPVS TSVFLEDCSD
260 270 280 290 300
CVLAVACQQL RVHTTKDTRI FLQVTSRAIM EDCTGIQFAP YTWSYPGIDK
310 320 330 340
DFEGSGLDKN KNNWNDVDDF NWLARDVASP NWNVLPEEER RIQWD
Length:345
Mass (Da):38,903
Last modified:October 11, 2005 - v1
Checksum:iAC953C5E29D45158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102901 mRNA. Translation: AAI02902.1.
RefSeqiNP_001069177.1. NM_001075709.2.
UniGeneiBt.49077.

Genome annotation databases

EnsembliENSBTAT00000001245; ENSBTAP00000001245; ENSBTAG00000000940.
GeneIDi515354.
KEGGibta:515354.

Similar proteinsi

Entry informationi

Entry nameiTBCC_BOVIN
AccessioniPrimary (citable) accession number: Q3SZE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families