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Protein

Tubulin-specific chaperone C

Gene

TBCC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin-folding protein; involved in the final step of the tubulin folding pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-BTA-389977. Post-chaperonin tubulin folding pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone C
Alternative name(s):
Tubulin-folding cofactor C
Short name:
CFC
Gene namesi
Name:TBCC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Detected predominantly in the photoreceptor connecting cilium.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Tubulin-specific chaperone CPRO_0000285106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei80 – 801PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SZE9.
PRIDEiQ3SZE9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000940.

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001245.

Structurei

3D structure databases

ProteinModelPortaliQ3SZE9.
SMRiQ3SZE9. Positions 181-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 322153C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TBCC family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2512. Eukaryota.
ENOG410Y28B. LUCA.
GeneTreeiENSGT00530000063741.
HOGENOMiHOG000030935.
HOVERGENiHBG017893.
InParanoidiQ3SZE9.
OMAiEKSDFFA.
OrthoDBiEOG091G0K00.
TreeFamiTF105832.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR006599. CARP_motif.
IPR027684. TBCC.
IPR031925. TBCC_N.
IPR012945. Tubulin-bd_cofactor_C_dom.
[Graphical view]
PANTHERiPTHR15139. PTHR15139. 1 hit.
PfamiPF07986. TBCC. 1 hit.
PF16752. TBCC_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGGLSAAA LANGDLGSQR ERTLVPERLQ KREHERQLEV ERRKQKRQDQ
60 70 80 90 100
EVEEEKSDFF AAAFARERSA VEELLESGES VERLEEAAAR LQGLQKLIND
110 120 130 140 150
SVLFLAAYDL RQAQEVLARL QAALAKRRQE LQPKKRFAFK TRKKDAASAT
160 170 180 190 200
QVASAPDAPA AEGSLTSPPP LKEEGDFDSS WICGFSNLQS QVLEKRAEEL
210 220 230 240 250
HQQDVLLTQL RNCTIKLYGN PNTLRLTKAQ GCTLLCGPVS TSVFLEDCSD
260 270 280 290 300
CVLAVACQQL RVHTTKDTRI FLQVTSRAIM EDCTGIQFAP YTWSYPGIDK
310 320 330 340
DFEGSGLDKN KNNWNDVDDF NWLARDVASP NWNVLPEEER RIQWD
Length:345
Mass (Da):38,903
Last modified:October 11, 2005 - v1
Checksum:iAC953C5E29D45158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102901 mRNA. Translation: AAI02902.1.
RefSeqiNP_001069177.1. NM_001075709.2.
UniGeneiBt.49077.

Genome annotation databases

EnsembliENSBTAT00000001245; ENSBTAP00000001245; ENSBTAG00000000940.
GeneIDi515354.
KEGGibta:515354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102901 mRNA. Translation: AAI02902.1.
RefSeqiNP_001069177.1. NM_001075709.2.
UniGeneiBt.49077.

3D structure databases

ProteinModelPortaliQ3SZE9.
SMRiQ3SZE9. Positions 181-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001245.

Proteomic databases

PaxDbiQ3SZE9.
PRIDEiQ3SZE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001245; ENSBTAP00000001245; ENSBTAG00000000940.
GeneIDi515354.
KEGGibta:515354.

Organism-specific databases

CTDi6903.

Phylogenomic databases

eggNOGiKOG2512. Eukaryota.
ENOG410Y28B. LUCA.
GeneTreeiENSGT00530000063741.
HOGENOMiHOG000030935.
HOVERGENiHBG017893.
InParanoidiQ3SZE9.
OMAiEKSDFFA.
OrthoDBiEOG091G0K00.
TreeFamiTF105832.

Enzyme and pathway databases

ReactomeiR-BTA-389977. Post-chaperonin tubulin folding pathway.

Gene expression databases

BgeeiENSBTAG00000000940.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR006599. CARP_motif.
IPR027684. TBCC.
IPR031925. TBCC_N.
IPR012945. Tubulin-bd_cofactor_C_dom.
[Graphical view]
PANTHERiPTHR15139. PTHR15139. 1 hit.
PfamiPF07986. TBCC. 1 hit.
PF16752. TBCC_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCC_BOVIN
AccessioniPrimary (citable) accession number: Q3SZE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.