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Protein

Phospholipid phosphatase 3

Gene

PLPP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 3By similarity (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 3
PAP2-beta
Phosphatidate phosphohydrolase type 2b
Phosphatidic acid phosphatase 2b
Short name:
PAP-2b
Short name:
PAP2b
Gene namesi
Name:PLPP3By similarity
Synonyms:PPAP2B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 85LumenalSequence analysisAdd BLAST31
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 123CytoplasmicSequence analysisAdd BLAST17
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 194LumenalSequence analysisAdd BLAST50
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 228CytoplasmicSequence analysisAdd BLAST13
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 258LumenalSequence analysis9
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 311CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869421 – 311Phospholipid phosphatase 3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Modified residuei298PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3SZE3.
PRIDEiQ3SZE3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011640.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015460.

Structurei

3D structure databases

ProteinModelPortaliQ3SZE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiQ3SZE3.
KOiK01080.
OMAiTINCAKG.
OrthoDBiEOG091G0K5H.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028675. LPP3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF79. PTHR10165:SF79. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SZE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNYKYDKAI VAESKNGGSP ALNNNPRKGG SKRVLLICLD LFCLFMAGLP
60 70 80 90 100
FIIIETSTIK PYHRGFYCND ESIKYPQKTG ETINDAVLTA VGIVIAILAI
110 120 130 140 150
ITGEFYRIYY LKEKSRSTIQ NPYVAALYKQ VGCFLFGCAI SQSFTDIAKV
160 170 180 190 200
SIGRLRPHFL NVCNPDFSQI NCSVGYIQNY RCRGEDSKVQ EARKSFFSGH
210 220 230 240 250
ASFSMYTMLY LVLYLQARFT WRGARLLRPL LQFTLIMMAF YTGLSRVSDH
260 270 280 290 300
KHHPSDVLAG FAQGALVACC IVFFVSDLFK TKTTLSLPPS AIRKDMLSPV
310
DIDRSNHHNM V
Length:311
Mass (Da):35,033
Last modified:October 11, 2005 - v1
Checksum:iB365EECCA46CFE97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102920 mRNA. Translation: AAI02921.1.
RefSeqiNP_001069941.1. NM_001076473.2.
UniGeneiBt.48940.

Genome annotation databases

EnsembliENSBTAT00000015460; ENSBTAP00000015460; ENSBTAG00000011640.
GeneIDi617707.
KEGGibta:617707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102920 mRNA. Translation: AAI02921.1.
RefSeqiNP_001069941.1. NM_001076473.2.
UniGeneiBt.48940.

3D structure databases

ProteinModelPortaliQ3SZE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015460.

Proteomic databases

PaxDbiQ3SZE3.
PRIDEiQ3SZE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015460; ENSBTAP00000015460; ENSBTAG00000011640.
GeneIDi617707.
KEGGibta:617707.

Organism-specific databases

CTDi8613.

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiQ3SZE3.
KOiK01080.
OMAiTINCAKG.
OrthoDBiEOG091G0K5H.
TreeFamiTF316040.

Enzyme and pathway databases

ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.

Gene expression databases

BgeeiENSBTAG00000011640.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028675. LPP3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF79. PTHR10165:SF79. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPP3_BOVIN
AccessioniPrimary (citable) accession number: Q3SZE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.