Reviewed, UniProtKB/Swiss-Prot Q3SZE3 (LPP3_BOVIN)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphohydrolase 3
    EC=3.1.3.4
Alternative name(s):
    Phosphatidic acid phosphatase 2b
    PAP2-beta
      Short name=PAP-2b
      Short name=PAP2b
    Phosphatidate phosphohydrolase type 2b

Gene names

Name:

PPAP2B

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) By similarity.
Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Lipid phosphate phosphohydrolase 3		PRO_0000286942
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Potential
	Topological domain	55 – 85	31	Lumenal Potential
	Transmembrane	86 – 106	21	Potential
	Topological domain	107 – 123	17	Cytoplasmic Potential
	Transmembrane	124 – 144	21	Potential
	Topological domain	145 – 194	50	Lumenal Potential
	Transmembrane	195 – 215	21	Potential
	Topological domain	216 – 228	13	Cytoplasmic Potential
	Transmembrane	229 – 249	21	Potential
	Topological domain	250 – 258	9	Lumenal Potential
	Transmembrane	259 – 279	21	Potential
	Topological domain	280 – 311	32	Cytoplasmic Potential
Amino acid modifications
	Modified residue	19	1	Phosphoserine By similarity
	Modified residue	110	1	Phosphotyrosine By similarity
	Modified residue	298	1	Phosphoserine By similarity
	Glycosylation	171	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3SZE3-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: B365EECCA46CFE97	FASTA	311	35,033
	10 20 30 40 50 60 MQNYKYDKAI VAESKNGGSP ALNNNPRKGG SKRVLLICLD LFCLFMAGLP FIIIETSTIK 70 80 90 100 110 120 PYHRGFYCND ESIKYPQKTG ETINDAVLTA VGIVIAILAI ITGEFYRIYY LKEKSRSTIQ 130 140 150 160 170 180 NPYVAALYKQ VGCFLFGCAI SQSFTDIAKV SIGRLRPHFL NVCNPDFSQI NCSVGYIQNY 190 200 210 220 230 240 RCRGEDSKVQ EARKSFFSGH ASFSMYTMLY LVLYLQARFT WRGARLLRPL LQFTLIMMAF 250 260 270 280 290 300 YTGLSRVSDH KHHPSDVLAG FAQGALVACC IVFFVSDLFK TKTTLSLPPS AIRKDMLSPV 310 DIDRSNHHNM V

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102920 mRNA. Translation: AAI02921.1.
IPI	IPI00711816.
RefSeq	NP_001069941.1.
UniGene	Bt.48940
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000011640. Bos taurus. [Contig view]
GeneID	617707.
KEGG	bta:617707.
Phylogenomic databases
HOVERGEN	Q3SZE3.
Enzyme and pathway databases
BRENDA	3.1.3.4. 251.
Family and domain databases
InterPro	IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPP3_BOVIN

Accession

Primary (citable) accession number: Q3SZE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 11, 2005
Last modified:	March 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)