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Protein

Peroxisomal biogenesis factor 19

Gene

PEX19

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

ReactomeiR-BTA-1369062. ABC transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 19
Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein
Gene namesi
Name:PEX19
Synonyms:PXF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 296295Peroxisomal biogenesis factor 19PRO_0000253623Add
BLAST
Propeptidei297 – 2993Removed in mature formBy similarityPRO_0000396699

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei66 – 661PhosphoserineBy similarity
Modified residuei236 – 2361PhosphothreonineBy similarity
Modified residuei296 – 2961Cysteine methyl esterBy similarity
Lipidationi296 – 2961S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ3SZD1.
PeptideAtlasiQ3SZD1.
PRIDEiQ3SZD1.

Interactioni

Subunit structurei

Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009921.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 9190Necessary for PEX19 function on peroxisome biogenesisAdd
BLAST
Regioni2 – 5655Docking to the peroxisome membrane and binding to PEX3Add
BLAST

Sequence similaritiesi

Belongs to the peroxin-19 family.Curated

Phylogenomic databases

eggNOGiKOG3133. Eukaryota.
ENOG4111QGU. LUCA.
GeneTreeiENSGT00390000010993.
HOGENOMiHOG000038537.
HOVERGENiHBG053573.
InParanoidiQ3SZD1.
KOiK13337.
OMAiMGDICKL.
OrthoDBiEOG7P5T1P.
TreeFamiTF315082.

Family and domain databases

InterProiIPR006708. Pex19.
[Graphical view]
PANTHERiPTHR12774. PTHR12774. 1 hit.
PfamiPF04614. Pex19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEGDGGV RAEADRELEE LLESALDDFD KAKPSPAPPP TTTAPDASGP
60 70 80 90 100
QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH
110 120 130 140 150
LVEQFQKLSE AAGRVGSDAT SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE
160 170 180 190 200
EELTKAMEGL GMDEGDGEGT ILPIMQSIMQ NLLSRDVLYP SLKEITEKYP
210 220 230 240 250
EWLRAHRDSL PPEQFEKYQE QHSVMGKICE QFEAETPTDS EATQKARFEV
260 270 280 290
VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM
Length:299
Mass (Da):32,667
Last modified:October 11, 2005 - v1
Checksum:iCCFADD95F62AB945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102949 mRNA. Translation: AAI02950.1.
RefSeqiNP_001029712.1. NM_001034540.2.
UniGeneiBt.46094.

Genome annotation databases

EnsembliENSBTAT00000009921; ENSBTAP00000009921; ENSBTAG00000007537.
GeneIDi521522.
KEGGibta:521522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102949 mRNA. Translation: AAI02950.1.
RefSeqiNP_001029712.1. NM_001034540.2.
UniGeneiBt.46094.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009921.

Proteomic databases

PaxDbiQ3SZD1.
PeptideAtlasiQ3SZD1.
PRIDEiQ3SZD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009921; ENSBTAP00000009921; ENSBTAG00000007537.
GeneIDi521522.
KEGGibta:521522.

Organism-specific databases

CTDi5824.

Phylogenomic databases

eggNOGiKOG3133. Eukaryota.
ENOG4111QGU. LUCA.
GeneTreeiENSGT00390000010993.
HOGENOMiHOG000038537.
HOVERGENiHBG053573.
InParanoidiQ3SZD1.
KOiK13337.
OMAiMGDICKL.
OrthoDBiEOG7P5T1P.
TreeFamiTF315082.

Enzyme and pathway databases

ReactomeiR-BTA-1369062. ABC transporters in lipid homeostasis.

Family and domain databases

InterProiIPR006708. Pex19.
[Graphical view]
PANTHERiPTHR12774. PTHR12774. 1 hit.
PfamiPF04614. Pex19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPEX19_BOVIN
AccessioniPrimary (citable) accession number: Q3SZD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.