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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene

ANP32B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Gene namesi
Name:ANP32B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus

  • Note: Accumulates in the nuclei at the S phase.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Acidic leucine-rich nuclear phosphoprotein 32 family member BPRO_0000236249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861N6-acetyllysineBy similarity
Modified residuei158 – 1581PhosphoserineBy similarity
Modified residuei254 – 2541PhosphothreonineBy similarity

Post-translational modificationi

Some Glu residues are glycylated by TTLL8; a modification that generates a side chains of glycine on the gamma-carboxyl groups of specific glutamate residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SZC6.
PeptideAtlasiQ3SZC6.
PRIDEiQ3SZC6.

Interactioni

Subunit structurei

Monomer. Interacts with histones H3 and H4 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3SZC6. 1 interaction.
STRINGi9913.ENSBTAP00000028486.

Structurei

3D structure databases

ProteinModelPortaliQ3SZC6.
SMRiQ3SZC6. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati16 – 4025LRR 1Add
BLAST
Repeati43 – 6422LRR 2Add
BLAST
Repeati65 – 8723LRR 3Add
BLAST
Repeati89 – 11022LRR 4Add
BLAST
Domaini123 – 16139LRRCTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 261111Asp/Glu-rich (highly acidic)Add
BLAST

Domaini

Histone binding is mediated by the concave surface of the LRR region.By similarity

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ3SZC6.
KOiK18647.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SZC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI
60 70 80 90 100
NVGLISVSNL PKLPKLKKLE LSDNRICGGL DMLAEKLPNL THLNLSGNKL
110 120 130 140 150
KDISTLEPLK KLECLKSLDL FNCEVTNLND YRESVFKLLP QLTYLDGYDR
160 170 180 190 200
EDREAPDSDA EVDGVDEEED DEEGEDEDKE EDEDGEEEEF DDEEDDDEDE
210 220 230 240 250
DVEGEEDEDE VSGEEEEFGH DGEVDEDDED EDEDEDEDEE EEESGKGEKR
260
KRETDDEGED D
Length:261
Mass (Da):29,872
Last modified:October 11, 2005 - v1
Checksum:i25133BB762971990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102954 mRNA. Translation: AAI02955.1.
RefSeqiNP_001030246.1. NM_001035074.1.
UniGeneiBt.111545.

Genome annotation databases

GeneIDi509685.
KEGGibta:509685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102954 mRNA. Translation: AAI02955.1.
RefSeqiNP_001030246.1. NM_001035074.1.
UniGeneiBt.111545.

3D structure databases

ProteinModelPortaliQ3SZC6.
SMRiQ3SZC6. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3SZC6. 1 interaction.
STRINGi9913.ENSBTAP00000028486.

Proteomic databases

PaxDbiQ3SZC6.
PeptideAtlasiQ3SZC6.
PRIDEiQ3SZC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi509685.
KEGGibta:509685.

Organism-specific databases

CTDi10541.

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ3SZC6.
KOiK18647.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAN32B_BOVIN
AccessioniPrimary (citable) accession number: Q3SZC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.