Q3SZC6 (AN32B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene names

Name:

ANP32B

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome By similarity.
Subunit structure	Monomer. Interacts with histones H3 and H4 By similarity.
Subcellular location	Nucleus. Note: Accumulates in the nuclei at the S phase By similarity.
Domain	Histone binding is mediated by the concave surface of the LRR region By similarity.
Post-translational modification	Some Glu residues are glycylated by TTLL8; a modification that generates a side chains of glycine on the gamma-carboxyl groups of specific glutamate residues By similarity.
Sequence similarities	Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Leucine-rich repeat Repeat
Molecular function	Chaperone
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleocytoplasmic transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Acidic leucine-rich nuclear phosphoprotein 32 family member B		PRO_0000236249
Regions
	Repeat	16 – 40	25	LRR 1
	Repeat	43 – 64	22	LRR 2
	Repeat	65 – 87	23	LRR 3
	Repeat	89 – 110	22	LRR 4
	Domain	123 – 161	39	LRRCT
	Compositional bias	151 – 261	111	Asp/Glu-rich (highly acidic)
Amino acid modifications
	Modified residue	86	1	N6-acetyllysine By similarity
	Modified residue	254	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZC6 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 25133BB762971990	FASTA	261	29,872
	10 20 30 40 50 60 MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI NVGLISVSNL 70 80 90 100 110 120 PKLPKLKKLE LSDNRICGGL DMLAEKLPNL THLNLSGNKL KDISTLEPLK KLECLKSLDL 130 140 150 160 170 180 FNCEVTNLND YRESVFKLLP QLTYLDGYDR EDREAPDSDA EVDGVDEEED DEEGEDEDKE 190 200 210 220 230 240 EDEDGEEEEF DDEEDDDEDE DVEGEEDEDE VSGEEEEFGH DGEVDEDDED EDEDEDEDEE 250 260 EEESGKGEKR KRETDDEGED D

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102954 mRNA. Translation: AAI02955.1.
IPI	IPI00699002.
RefSeq	NP_001030246.1. NM_001035074.1.
UniGene	Bt.7074.
3D structure databases
ProteinModelPortal	Q3SZC6.
SMR	Q3SZC6. Positions 1-161.
ModBase	Search...
Proteomic databases
PRIDE	Q3SZC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	509685.
KEGG	bta:509685.
Organism-specific databases
CTD	10541.
Phylogenomic databases
eggNOG	maNOG19758.
GeneTree	ENSGT00560000077130.
HOVERGEN	HBG053102.
InParanoid	Q3SZC6.
OrthoDB	EOG4QNMXG.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003603. U2A'_phosphoprotein32A_C. [Graphical view]
SMART	SM00446. LRRcap. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN32B_BOVIN

Accession

Primary (citable) accession number: Q3SZC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 11, 2005
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program