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Protein

GrpE protein homolog 1, mitochondrial

Gene

GRPEL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Short name:
mt-GrpE
Gene namesi
Name:GRPEL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion1 PublicationAdd
BLAST
Chaini28 – 217190GrpE protein homolog 1, mitochondrialPRO_0000245345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
Modified residuei100 – 1001N6-acetyllysineBy similarity
Modified residuei120 – 1201N6-succinyllysineBy similarity
Modified residuei215 – 2151N6-acetyllysine; alternateBy similarity
Modified residuei215 – 2151N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZC1.
PRIDEiQ3SZC1.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013431.

Structurei

3D structure databases

ProteinModelPortaliQ3SZC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ3SZC1.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG718KDB.
TreeFamiTF105284.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCVRLAR GSLPAFALSL RSSPRLLCTA AKQKNNGQNL EEDAGQNEQK
60 70 80 90 100
TDLPSTEKTL MEEKVKLEEQ LKETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQCVPQEEI RDDNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLNPLGAKF DPYEHEALFH TPVEGKEPGT VALVNKVGYK
210
LHGRTLRPAL VGVVKGA
Length:217
Mass (Da):24,306
Last modified:October 11, 2005 - v1
Checksum:i4BC6FB43FC049FF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281C → S AA sequence (PubMed:7711059).Curated
Sequence conflicti36 – 361N → D AA sequence (PubMed:7711059).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102964 mRNA. Translation: AAI02965.1.
RefSeqiNP_001029673.1. NM_001034501.2.
UniGeneiBt.48938.

Genome annotation databases

EnsembliENSBTAT00000013431; ENSBTAP00000013431; ENSBTAG00000010181.
GeneIDi515580.
KEGGibta:515580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102964 mRNA. Translation: AAI02965.1.
RefSeqiNP_001029673.1. NM_001034501.2.
UniGeneiBt.48938.

3D structure databases

ProteinModelPortaliQ3SZC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013431.

Proteomic databases

PaxDbiQ3SZC1.
PRIDEiQ3SZC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013431; ENSBTAP00000013431; ENSBTAG00000010181.
GeneIDi515580.
KEGGibta:515580.

Organism-specific databases

CTDi80273.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ3SZC1.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG718KDB.
TreeFamiTF105284.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. "Affinity-purification and identification of GrpE homologues from mammalian mitochondria."
    Naylor D.J., Ryan M.T., Condron R., Hoogenraad N.J., Hoj P.B.
    Biochim. Biophys. Acta 1248:75-79(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-55 AND 170-196.
    Tissue: Liver.

Entry informationi

Entry nameiGRPE1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZC1
Secondary accession number(s): Q9T2U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.