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Protein

Mitochondrial import inner membrane translocase subunit TIM50

Gene

TIMM50

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM50
Gene namesi
Name:TIMM50
Synonyms:TIM50
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 67Mitochondrial matrixSequence analysisAdd BLAST23
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 355Mitochondrial intermembraneSequence analysisAdd BLAST267

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_000004311445 – 355Mitochondrial import inner membrane translocase subunit TIM50Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SZB3
PeptideAtlasiQ3SZB3
PRIDEiQ3SZB3

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031959

Structurei

3D structure databases

ProteinModelPortaliQ3SZB3
SMRiQ3SZB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 288FCP1 homologyPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

Belongs to the TIM50 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2832 Eukaryota
COG5190 LUCA
HOVERGENiHBG084157
InParanoidiQ3SZB3
KOiK17496

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR027111 Tim50
PANTHERiPTHR12210:SF3 PTHR12210:SF3, 1 hit
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAAVFLR LRSGLRQGAR GLCARLATPP PRAPDQAAEI GSRAGTKAQT
60 70 80 90 100
QGPQQQRSSE GPSYAKKVAL WLARLLGAGG TVSVIYIFGN NAVDENGAKI
110 120 130 140 150
PDEFDNDPIL VQQLRRTYKY FKDYRQMIIE PTSPCLLPDP LREPYYQPPY
160 170 180 190 200
TLVLELTGVL LHPEWSLATG WRFKKRPGIE TLFQQLAPLY EIVIFTSETG
210 220 230 240 250
MTAFPLIDSV DPHGFISYRL FRDATRYMDG HHVKDISCLN RDPARVVVVD
260 270 280 290 300
CKKEAFRLQP YNGVALRPWD GNSDDRVLLD LSAFLKTIAL NGVEDVRTVL
310 320 330 340 350
EHYALEEDPL EAFKQRQSRL EQEEQQRLAE LSKSSKQNLF FSSLTSRLWP

RSKQP
Length:355
Mass (Da):40,109
Last modified:October 11, 2005 - v1
Checksum:i433FB15D8DEBB1AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102990 mRNA Translation: AAI02991.1
RefSeqiNP_001030196.1, NM_001035024.1
UniGeneiBt.49082

Genome annotation databases

GeneIDi505489
KEGGibta:505489

Similar proteinsi

Entry informationi

Entry nameiTIM50_BOVIN
AccessioniPrimary (citable) accession number: Q3SZB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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