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Protein

Mitochondrial import inner membrane translocase subunit TIM50

Gene

TIMM50

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM50
Gene namesi
Name:TIMM50
Synonyms:TIM50
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 6723Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 355267Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444MitochondrionSequence analysisAdd
BLAST
Chaini45 – 355311Mitochondrial import inner membrane translocase subunit TIM50PRO_0000043114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SZB3.
PeptideAtlasiQ3SZB3.
PRIDEiQ3SZB3.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031959.

Structurei

3D structure databases

ProteinModelPortaliQ3SZB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 288144FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TIM50 family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2832. Eukaryota.
COG5190. LUCA.
HOVERGENiHBG084157.
InParanoidiQ3SZB3.
KOiK17496.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR027111. Tim50.
[Graphical view]
PANTHERiPTHR12210:SF3. PTHR12210:SF3. 1 hit.
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAAVFLR LRSGLRQGAR GLCARLATPP PRAPDQAAEI GSRAGTKAQT
60 70 80 90 100
QGPQQQRSSE GPSYAKKVAL WLARLLGAGG TVSVIYIFGN NAVDENGAKI
110 120 130 140 150
PDEFDNDPIL VQQLRRTYKY FKDYRQMIIE PTSPCLLPDP LREPYYQPPY
160 170 180 190 200
TLVLELTGVL LHPEWSLATG WRFKKRPGIE TLFQQLAPLY EIVIFTSETG
210 220 230 240 250
MTAFPLIDSV DPHGFISYRL FRDATRYMDG HHVKDISCLN RDPARVVVVD
260 270 280 290 300
CKKEAFRLQP YNGVALRPWD GNSDDRVLLD LSAFLKTIAL NGVEDVRTVL
310 320 330 340 350
EHYALEEDPL EAFKQRQSRL EQEEQQRLAE LSKSSKQNLF FSSLTSRLWP

RSKQP
Length:355
Mass (Da):40,109
Last modified:October 11, 2005 - v1
Checksum:i433FB15D8DEBB1AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102990 mRNA. Translation: AAI02991.1.
RefSeqiNP_001030196.1. NM_001035024.1.
UniGeneiBt.49082.

Genome annotation databases

GeneIDi505489.
KEGGibta:505489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102990 mRNA. Translation: AAI02991.1.
RefSeqiNP_001030196.1. NM_001035024.1.
UniGeneiBt.49082.

3D structure databases

ProteinModelPortaliQ3SZB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031959.

Proteomic databases

PaxDbiQ3SZB3.
PeptideAtlasiQ3SZB3.
PRIDEiQ3SZB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi505489.
KEGGibta:505489.

Organism-specific databases

CTDi92609.

Phylogenomic databases

eggNOGiKOG2832. Eukaryota.
COG5190. LUCA.
HOVERGENiHBG084157.
InParanoidiQ3SZB3.
KOiK17496.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR027111. Tim50.
[Graphical view]
PANTHERiPTHR12210:SF3. PTHR12210:SF3. 1 hit.
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIM50_BOVIN
AccessioniPrimary (citable) accession number: Q3SZB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.