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Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:RPL13A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 20320260S ribosomal protein L13aPRO_0000230999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei59 – 591CitrullineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei140 – 1401CitrullineBy similarity
Modified residuei191 – 1911N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ3SZ90.
PeptideAtlasiQ3SZ90.
PRIDEiQ3SZ90.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005296.

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040732.

Structurei

3D structure databases

ProteinModelPortaliQ3SZ90.
SMRiQ3SZ90. Positions 7-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L13P family.Curated

Phylogenomic databases

eggNOGiKOG3204. Eukaryota.
COG0102. LUCA.
GeneTreeiENSGT00390000010799.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiQ3SZ90.
KOiK02872.
OMAiYYERKKV.
OrthoDBiEOG091G0PUZ.
TreeFamiTF300159.

Family and domain databases

CDDicd00392. Ribosomal_L13. 1 hit.
Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13. 1 hit.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZ90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN
60 70 80 90 100
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE
110 120 130 140 150
RLKVFDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ
160 170 180 190 200
AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ AEKNIEKKIG KFTEVLKTHG

FLV
Length:203
Mass (Da):23,523
Last modified:January 23, 2007 - v3
Checksum:i22F8FC6F0C961B1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103039 mRNA. Translation: AAI03040.1.
RefSeqiNP_001070466.1. NM_001076998.2.
UniGeneiBt.49211.

Genome annotation databases

EnsembliENSBTAT00000005007; ENSBTAP00000040732; ENSBTAG00000005296.
GeneIDi767925.
KEGGibta:767925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103039 mRNA. Translation: AAI03040.1.
RefSeqiNP_001070466.1. NM_001076998.2.
UniGeneiBt.49211.

3D structure databases

ProteinModelPortaliQ3SZ90.
SMRiQ3SZ90. Positions 7-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040732.

Proteomic databases

PaxDbiQ3SZ90.
PeptideAtlasiQ3SZ90.
PRIDEiQ3SZ90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005007; ENSBTAP00000040732; ENSBTAG00000005296.
GeneIDi767925.
KEGGibta:767925.

Organism-specific databases

CTDi23521.

Phylogenomic databases

eggNOGiKOG3204. Eukaryota.
COG0102. LUCA.
GeneTreeiENSGT00390000010799.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiQ3SZ90.
KOiK02872.
OMAiYYERKKV.
OrthoDBiEOG091G0PUZ.
TreeFamiTF300159.

Gene expression databases

BgeeiENSBTAG00000005296.

Family and domain databases

CDDicd00392. Ribosomal_L13. 1 hit.
Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13. 1 hit.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL13A_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.