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Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:RPL13A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002309992 – 20360S ribosomal protein L13aAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei59CitrullineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei140CitrullineBy similarity1
Modified residuei191N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ3SZ90.
PeptideAtlasiQ3SZ90.
PRIDEiQ3SZ90.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005296.

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040732.

Structurei

3D structure databases

ProteinModelPortaliQ3SZ90.
SMRiQ3SZ90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3204. Eukaryota.
COG0102. LUCA.
GeneTreeiENSGT00390000010799.
HOGENOMiHOG000225289.
HOVERGENiHBG062176.
InParanoidiQ3SZ90.
KOiK02872.
OMAiRYHNFLH.
OrthoDBiEOG091G0PUZ.
TreeFamiTF300159.

Family and domain databases

CDDicd00392. Ribosomal_L13. 1 hit.
Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13. 1 hit.
InterProiView protein in InterPro
IPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR005755. Ribosomal_L13_euk/arc.
IPR036899. Ribosomal_L13_sf.
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiView protein in Pfam
PF00572. Ribosomal_L13. 1 hit.
PIRSFiPIRSF002181. Ribosomal_L13. 1 hit.
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiView protein in PROSITE
PS00783. RIBOSOMAL_L13. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZ90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN
60 70 80 90 100
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE
110 120 130 140 150
RLKVFDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ
160 170 180 190 200
AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ AEKNIEKKIG KFTEVLKTHG

FLV
Length:203
Mass (Da):23,523
Last modified:January 23, 2007 - v3
Checksum:i22F8FC6F0C961B1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103039 mRNA. Translation: AAI03040.1.
RefSeqiNP_001070466.1. NM_001076998.2.
UniGeneiBt.49211.

Genome annotation databases

EnsembliENSBTAT00000005007; ENSBTAP00000040732; ENSBTAG00000005296.
GeneIDi767925.
KEGGibta:767925.

Similar proteinsi

Entry informationi

Entry nameiRL13A_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 78 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families