Q3SZ79 (LIPC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hepatic triacylglycerol lipase
Short name=HL
Short name=Hepatic lipase
EC=3.1.1.3

Alternative name(s):
Lipase member C

Gene names

Name:

LIPC

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin By similarity.
Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	HDL Secreted
Domain	Signal
Ligand	Heparin-binding
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 500	477	Hepatic triacylglycerol lipase		PRO_0000246183
Regions
	Domain	353 – 487	135	PLAT
	Region	181 – 193	13	Heparin-binding Potential
Sites
	Active site	168	1	Nucleophile By similarity
	Active site	194	1	Charge relay system By similarity
	Active site	279	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	363	1	N-linked (GlcNAc...) Potential
	Glycosylation	398	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3SZ79 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 65EECAF16C01B266	FASTA	500	56,826
	10 20 30 40 50 60 MENPLCVSIF LFYCILIQSS AHGQSLGPES FGRRSRAAET NKTPQETRTK FLLFRGETDK 70 80 90 100 110 120 GCQILLNHSD TLQQCGFNSS LPLVMIVHGW LVDDILEDWV WEMVAALKSQ LAQSVNVGLA 130 140 150 160 170 180 EWVTLAHNHY TTAVRNTRLV GQEIAALLQW LQESVQFSPS HVHLIGYSLG AHVSGFAGSY 190 200 210 220 230 240 MSRKHKIGRI TGLDAAGPLF EKASLSDRLS PDDANFVDAI HTFTWEHMGL SVGMKQPIAH 250 260 270 280 290 300 YDFYPNGGSY QPGCHFLELY KHFAKHGLNA ITRTVKCAHE RSVHLFIDSL LHADMQSMAY 310 320 330 340 350 360 LCRDMDRFSQ GLCLSCKKGR CNTLGYHTRQ ERQSKKSKSL FLVTRAQSPF KVYHYQFKIR 370 380 390 400 410 420 FINQTENPVE PTFTVSFLGT RGERQKIPIT LSKGITSNET YSFLITLDVD IGELIMIKFK 430 440 450 460 470 480 WENRMVWSNV WNTVQTIIPW GRGSLHSGLA LKSIRVKVGE TQQRMTFCSE NMNDLLLHPA 490 500 REKTFVRCEA NSETLKRKIR

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103072 mRNA. Translation: AAI03073.1.
IPI	IPI00714758.
RefSeq	NP_001030487.1. NM_001035410.1.
UniGene	Bt.92704.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q3SZ79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	535192.
KEGG	bta:535192.
Organism-specific databases
CTD	3990.
Phylogenomic databases
eggNOG	maNOG15677.
HOVERGEN	HBG002259.
Enzyme and pathway databases
BioCyc	CATTLE:535192-MONOMER.
Family and domain databases
InterPro	IPR000734. Lipase. IPR002333. Lipase_hep. IPR008976. Lipase_LipOase. IPR013818. Lipase_N. IPR001024. LipOase_LH2. IPR016272. Lipoprotein_lipase_LIPH. [Graphical view]
Gene3D	G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
KO	K01046.
PANTHER	PTHR11610. Lipase. 1 hit. PTHR11610:SF2. Lipase_hep. 1 hit.
Pfam	PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PIRSF	PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTS	PR00824. HEPLIPASE. PR00821. TAGLIPASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
SUPFAM	SSF49723. Lipase_LipOase. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIPC_BOVIN

Accession

Primary (citable) accession number: Q3SZ79

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program