ID   MPPB_BOVIN              Reviewed;         490 AA.
AC   Q3SZ71;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Mitochondrial-processing peptidase subunit beta;
DE            EC=3.4.24.64;
DE   AltName: Full=Beta-MPP;
DE   Flags: Precursor;
GN   Name=PMPCB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cleaves presequences (transit peptides) from
CC       mitochondrial protein precursors (By similarity).
CC   -!- CATALYTIC ACTIVITY: Release of N-terminal transit peptides from
CC       precursor proteins imported into the mitochondrion, typically with
CC       Arg in position P2.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Heterodimer of alpha and beta subunits (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
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DR   EMBL; BC103085; AAI03086.1; -; mRNA.
DR   IPI; IPI00713456; -.
DR   RefSeq; NP_001029785.1; -.
DR   UniGene; Bt.87343; -.
DR   MEROPS; M16.003; -.
DR   Ensembl; ENSBTAG00000006876; Bos taurus.
DR   GeneID; 534546; -.
DR   KEGG; bta:534546; -.
DR   HOVERGEN; Q3SZ71; -.
DR   OMA; Q3SZ71; IPLMVAN.
DR   BRENDA; 3.4.24.64; 251.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR011237; Pept_M16_core.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   Gene3D; G3DSA:3.30.830.10; Pept_M16_core; 2.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Protease;
KW   Transit peptide; Zinc.
FT   TRANSIT       1     46       Mitochondrion (Potential).
FT   CHAIN        47    490       Mitochondrial-processing peptidase
FT                                subunit beta.
FT                                /FTId=PRO_0000045850.
FT   ACT_SITE    105    105       Proton acceptor (By similarity).
FT   METAL       102    102       Zinc (By similarity).
FT   METAL       106    106       Zinc (By similarity).
FT   METAL       182    182       Zinc (By similarity).
SQ   SEQUENCE   490 AA;  54237 MW;  9C600D19B6712AFE CRC64;
     MAAAAVARAV LFSAARRRLC GFTERLLIGG AAGRSLYFGG NRLRSTQAAA QVVLNVPETR
     VTCLENGLRV ASEDSGLATC TVGLWIDAGS RYENEKNNGT AHFLEHMAFK GTKKRSQLDL
     ELEIENMGAH LNAYTSREQT VYYAKAFSKD LPRAVEILAD IIQNSTLGEA EIERERGVIL
     REMQEVETNL QEVVFDYLHA TAYQNTALGR TILGPTENIK SINRKDLVDY ITTHYKGPRI
     VLAAAGGVSH DELLELAKFH FGESLSTHKG EIPALPPCKF TGSEIRVRDD KMPLAHLAVA
     VEAVGWAHPD TICLMVANTL IGNWDRSFGG GMNLSSKLAQ LTCHGNLCHS FQSFNTSYTD
     TGLWGIYMVC EPATVADMLH VVQKEWMRLC TSVTESEVAR AKNLLKTNML LQLDGSTPIC
     EDIGRQMLCY NRRIPIPELE ARIDAVNAEI IREVCTKYIY DKSPAVAAVG PIEQLPDFNQ
     ICSNMRWLHD
//