Reviewed, UniProtKB/Swiss-Prot Q3SZ71 (MPPB_BOVIN)

Names and origin

Protein names

Recommended name:
    Mitochondrial-processing peptidase subunit beta
    EC=3.4.24.64
Alternative name(s):
    Beta-MPP

Gene names

Name:

PMPCB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cleaves presequences (transit peptides) from mitochondrial protein precursors By similarity.
Catalytic activity	Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of alpha and beta subunits By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peptidase M16 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 46	46	Mitochondrion Potential
	Chain	47 – 490	444	Mitochondrial-processing peptidase subunit beta		PRO_0000045850
Sites
	Active site	105	1	Proton acceptor By similarity
	Metal binding	102	1	Zinc By similarity
	Metal binding	106	1	Zinc By similarity
	Metal binding	182	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZ71-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 9C600D19B6712AFE	FASTA	490	54,237
	10 20 30 40 50 60 MAAAAVARAV LFSAARRRLC GFTERLLIGG AAGRSLYFGG NRLRSTQAAA QVVLNVPETR 70 80 90 100 110 120 VTCLENGLRV ASEDSGLATC TVGLWIDAGS RYENEKNNGT AHFLEHMAFK GTKKRSQLDL 130 140 150 160 170 180 ELEIENMGAH LNAYTSREQT VYYAKAFSKD LPRAVEILAD IIQNSTLGEA EIERERGVIL 190 200 210 220 230 240 REMQEVETNL QEVVFDYLHA TAYQNTALGR TILGPTENIK SINRKDLVDY ITTHYKGPRI 250 260 270 280 290 300 VLAAAGGVSH DELLELAKFH FGESLSTHKG EIPALPPCKF TGSEIRVRDD KMPLAHLAVA 310 320 330 340 350 360 VEAVGWAHPD TICLMVANTL IGNWDRSFGG GMNLSSKLAQ LTCHGNLCHS FQSFNTSYTD 370 380 390 400 410 420 TGLWGIYMVC EPATVADMLH VVQKEWMRLC TSVTESEVAR AKNLLKTNML LQLDGSTPIC 430 440 450 460 470 480 EDIGRQMLCY NRRIPIPELE ARIDAVNAEI IREVCTKYIY DKSPAVAAVG PIEQLPDFNQ 490 ICSNMRWLHD

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC103085 mRNA. Translation: AAI03086.1.
IPI	IPI00713456.
RefSeq	NP_001029785.1.
UniGene	Bt.87343
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M16.003.
Genome annotation databases
Ensembl	ENSBTAG00000006876. Bos taurus. [Contig view]
GeneID	534546.
KEGG	bta:534546.
Phylogenomic databases
HOVERGEN	Q3SZ71.
OMA	Q3SZ71. IPLMVAN.
Enzyme and pathway databases
BRENDA	3.4.24.64. 251.
Family and domain databases
InterPro	IPR011237. Pept_M16_core. IPR011765. Pept_M16_N. IPR001431. Pept_M16_Zn_BS. IPR007863. Peptidase_M16_C. [Graphical view]
Gene3D	G3DSA:3.30.830.10. Pept_M16_core. 2 hits.
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view]
PROSITE	PS00143. INSULINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPPB_BOVIN

Accession

Primary (citable) accession number: Q3SZ71

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)