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Q3SZ71 (MPPB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mitochondrial-processing peptidase subunit beta
EC=3.4.24.64
Alternative name(s):
Beta-MPP
Gene names
Name:PMPCB
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves presequences (transit peptides) from mitochondrial protein precursors By similarity.

Catalytic activity

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of alpha and beta subunits By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peptidase M16 family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4646Mitochondrion By similarity
Chain47 – 490444Mitochondrial-processing peptidase subunit beta
PRO_0000045850

Sites

Active site1051Proton acceptor By similarity
Metal binding1021Zinc By similarity
Metal binding1061Zinc By similarity
Metal binding1821Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SZ71 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 9C600D19B6712AFE

FASTA49054,237
        10         20         30         40         50         60 
MAAAAVARAV LFSAARRRLC GFTERLLIGG AAGRSLYFGG NRLRSTQAAA QVVLNVPETR 

        70         80         90        100        110        120 
VTCLENGLRV ASEDSGLATC TVGLWIDAGS RYENEKNNGT AHFLEHMAFK GTKKRSQLDL 

       130        140        150        160        170        180 
ELEIENMGAH LNAYTSREQT VYYAKAFSKD LPRAVEILAD IIQNSTLGEA EIERERGVIL 

       190        200        210        220        230        240 
REMQEVETNL QEVVFDYLHA TAYQNTALGR TILGPTENIK SINRKDLVDY ITTHYKGPRI 

       250        260        270        280        290        300 
VLAAAGGVSH DELLELAKFH FGESLSTHKG EIPALPPCKF TGSEIRVRDD KMPLAHLAVA 

       310        320        330        340        350        360 
VEAVGWAHPD TICLMVANTL IGNWDRSFGG GMNLSSKLAQ LTCHGNLCHS FQSFNTSYTD 

       370        380        390        400        410        420 
TGLWGIYMVC EPATVADMLH VVQKEWMRLC TSVTESEVAR AKNLLKTNML LQLDGSTPIC 

       430        440        450        460        470        480 
EDIGRQMLCY NRRIPIPELE ARIDAVNAEI IREVCTKYIY DKSPAVAAVG PIEQLPDFNQ 

       490 
ICSNMRWLHD

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC103085 mRNA. Translation: AAI03086.1.
IPIIPI00713456.
RefSeqNP_001029785.1. NM_001034613.1.
UniGeneBt.61294.

3D structure databases

ProteinModelPortalQ3SZ71.
SMRQ3SZ71. Positions 50-487.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3SZ71.

Protein family/group databases

MEROPSM16.003.

Proteomic databases

PRIDEQ3SZ71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID534546.
KEGGbta:534546.

Organism-specific databases

CTD9512.

Phylogenomic databases

eggNOGmaNOG11940.
GeneTreeENSGT00550000074701.
HOVERGENHBG006393.
InParanoidQ3SZ71.
OMAIPLMVAN.
OrthoDBEOG4XPQFR.
PhylomeDBQ3SZ71.

Family and domain databases

InterProIPR011249. Metalloenz_metal-bd.
IPR011237. Pept_M16_core.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
Gene3DG3DSA:3.30.830.10. Pept_M16_core. 2 hits.
KOK01412.
PfamPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMSSF63411. Metalloenz_metal-bd. 2 hits.
PROSITEPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPPB_BOVIN
AccessionPrimary (citable) accession number: Q3SZ71
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 11, 2005
Last modified: November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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