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Protein

Ragulator complex protein LAMTOR5

Gene

LAMTOR5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-1632852. Macroautophagy.
R-BTA-165159. mTOR signalling.
R-BTA-166208. mTORC1-mediated signalling.
R-BTA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-BTA-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR5
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Gene namesi
Name:LAMTOR5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9191Ragulator complex protein LAMTOR5PRO_0000331594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZ68.

Interactioni

Subunit structurei

Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019928.

Structurei

3D structure databases

ProteinModelPortaliQ3SZ68.
SMRiQ3SZ68. Positions 1-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR5 family.Curated

Phylogenomic databases

eggNOGiENOG410IZVH. Eukaryota.
ENOG4111WFD. LUCA.
GeneTreeiENSGT00390000006247.
HOGENOMiHOG000045746.
HOVERGENiHBG010343.
InParanoidiQ3SZ68.
KOiK16344.
OMAiPTVCLES.
OrthoDBiEOG7FNCBP.
TreeFamiTF324433.

Family and domain databases

InterProiIPR024135. LAMTOR5.
[Graphical view]
PANTHERiPTHR13342. PTHR13342. 1 hit.
PfamiPF16672. LAMTOR5. 1 hit.
[Graphical view]
PRINTSiPR02092. HEPBVIRUSXIP.

Sequencei

Sequence statusi: Complete.

Q3SZ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ
60 70 80 90
QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Length:91
Mass (Da):9,614
Last modified:October 11, 2005 - v1
Checksum:i01D9E762ABC63980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103091 mRNA. Translation: AAI03092.1.
RefSeqiNP_001029689.1. NM_001034517.2.
UniGeneiBt.8810.

Genome annotation databases

EnsembliENSBTAT00000019928; ENSBTAP00000019928; ENSBTAG00000014970.
GeneIDi516090.
KEGGibta:516090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103091 mRNA. Translation: AAI03092.1.
RefSeqiNP_001029689.1. NM_001034517.2.
UniGeneiBt.8810.

3D structure databases

ProteinModelPortaliQ3SZ68.
SMRiQ3SZ68. Positions 1-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019928.

Proteomic databases

PaxDbiQ3SZ68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019928; ENSBTAP00000019928; ENSBTAG00000014970.
GeneIDi516090.
KEGGibta:516090.

Organism-specific databases

CTDi10542.

Phylogenomic databases

eggNOGiENOG410IZVH. Eukaryota.
ENOG4111WFD. LUCA.
GeneTreeiENSGT00390000006247.
HOGENOMiHOG000045746.
HOVERGENiHBG010343.
InParanoidiQ3SZ68.
KOiK16344.
OMAiPTVCLES.
OrthoDBiEOG7FNCBP.
TreeFamiTF324433.

Enzyme and pathway databases

ReactomeiR-BTA-1632852. Macroautophagy.
R-BTA-165159. mTOR signalling.
R-BTA-166208. mTORC1-mediated signalling.
R-BTA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-BTA-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi20872131.

Family and domain databases

InterProiIPR024135. LAMTOR5.
[Graphical view]
PANTHERiPTHR13342. PTHR13342. 1 hit.
PfamiPF16672. LAMTOR5. 1 hit.
[Graphical view]
PRINTSiPR02092. HEPBVIRUSXIP.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiLTOR5_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: February 17, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.