Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ragulator complex protein LAMTOR5

Gene

LAMTOR5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR5
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Gene namesi
Name:LAMTOR5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315941 – 91Ragulator complex protein LAMTOR5Add BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZ68
PeptideAtlasiQ3SZ68
PRIDEiQ3SZ68

Expressioni

Gene expression databases

BgeeiENSBTAG00000014970

Interactioni

Subunit structurei

Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019928

Structurei

3D structure databases

ProteinModelPortaliQ3SZ68
SMRiQ3SZ68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR5 family.Curated

Phylogenomic databases

eggNOGiENOG410IZVH Eukaryota
ENOG4111WFD LUCA
GeneTreeiENSGT00390000006247
HOGENOMiHOG000045746
HOVERGENiHBG010343
InParanoidiQ3SZ68
KOiK16344
OMAiPTVCLES
OrthoDBiEOG091G18B1
TreeFamiTF324433

Family and domain databases

InterProiView protein in InterPro
IPR024135 LAMTOR5
PANTHERiPTHR13342 PTHR13342, 1 hit
PfamiView protein in Pfam
PF16672 LAMTOR5, 1 hit
PRINTSiPR02092 HEPBVIRUSXIP

Sequencei

Sequence statusi: Complete.

Q3SZ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ
60 70 80 90
QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Length:91
Mass (Da):9,614
Last modified:October 11, 2005 - v1
Checksum:i01D9E762ABC63980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103091 mRNA Translation: AAI03092.1
RefSeqiNP_001029689.1, NM_001034517.2
UniGeneiBt.8810

Genome annotation databases

EnsembliENSBTAT00000019928; ENSBTAP00000019928; ENSBTAG00000014970
GeneIDi516090
KEGGibta:516090

Similar proteinsi

Entry informationi

Entry nameiLTOR5_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health