Q3SZ62 (PGAM1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate mutase 1
EC=3.1.3.13
EC=5.4.2.1
EC=5.4.2.4

Alternative name(s):
BPG-dependent PGAM 1
Phosphoglycerate mutase isozyme B
Short name=PGAM-B

Gene names

Name:

PGAM1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Hydrolase Isomerase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	bisphosphoglycerate 2-phosphatase activity Inferred from electronic annotation. Source: EC bisphosphoglycerate mutase activity Inferred from electronic annotation. Source: EC phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Phosphoglycerate mutase 1		PRO_0000246079
Regions
	Compositional bias	122 – 131	10	Pro-rich
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	186	1	By similarity
	Site	62	1	Interaction with carboxyl group of phosphoglycerates By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	14	1	Phosphoserine By similarity
	Modified residue	26	1	Phosphotyrosine By similarity
	Modified residue	31	1	Phosphoserine By similarity
	Modified residue	92	1	Phosphotyrosine By similarity
	Modified residue	118	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZ62 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 233E2F8EEBB222A1	FASTA	254	28,852
	10 20 30 40 50 60 MAAYKLVLIR HGESTWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ 70 80 90 100 110 120 KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 130 140 150 160 170 180 VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR 190 200 210 220 230 240 VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPMVYEL DKNLKPIKPM QFLGDEETVR 250 KAMEAVAAQG KAKK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103115 mRNA. Translation: AAI03116.1.
IPI	IPI00698589.
RefSeq	NP_001029226.1. NM_001034054.1.
UniGene	Bt.15319.
3D structure databases
ProteinModelPortal	Q3SZ62.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SZ62.
Proteomic databases
PRIDE	Q3SZ62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000032937; ENSBTAP00000032864; ENSBTAG00000012697.
GeneID	404148.
KEGG	bta:404148.
Organism-specific databases
CTD	5223.
Phylogenomic databases
eggNOG	maNOG12725.
GeneTree	ENSGT00390000016700.
HOVERGEN	HBG027528.
InParanoid	Q3SZ62.
OMA	EWNALNL.
OrthoDB	EOG4MCX10.
PhylomeDB	Q3SZ62.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGAM1_BOVIN

Accession

Primary (citable) accession number: Q3SZ62

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program