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Protein

Recombining binding protein suppressor of hairless

Gene

RBPJ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (By similarity). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi45 – 528By similarity
DNA bindingi179 – 18810By similarity
DNA bindingi252 – 28433By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-2122947. NOTCH1 Intracellular Domain Regulates Transcription.
R-BTA-2197563. NOTCH2 intracellular domain regulates transcription.
R-BTA-350054. Notch-HLH transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless
Alternative name(s):
J kappa-recombination signal-binding protein
RBP-J kappa
Gene namesi
Name:RBPJ
Synonyms:RBPSUH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Recombining binding protein suppressor of hairlessPRO_0000260076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZ41.
PRIDEiQ3SZ41.

Interactioni

Subunit structurei

Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with RITA1, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Interacts with SNW1 (By similarity). Interacts with CHCHD2 and CXXC5. Interacts with BEND6 (via BEN domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004696.

Structurei

3D structure databases

ProteinModelPortaliQ3SZ41.
SMRiQ3SZ41. Positions 12-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini342 – 43291IPT/TIGAdd
BLAST

Sequence similaritiesi

Belongs to the Su(H) family.Curated
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3743. Eukaryota.
ENOG410XV7K. LUCA.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiQ3SZ41.
KOiK06053.
OMAiVIVILHA.
OrthoDBiEOG7BP826.
TreeFamiTF314117.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SMARTiSM01268. BTD. 1 hit.
SM01267. LAG1_DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SZ41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVVTGKFG ERPPPKRLTR EAMRNYLKER GDQTVLILHA KVAQKSYGNE
60 70 80 90 100
KRFFCPPPCV YLMGSGWKKK KEQMERDGCS EQESQPCAFI GIGNSDQEMQ
110 120 130 140 150
QLNLEGKNYC TAKTLYISDS DKRKHFMLSV KMFYGNSDDI GVFLSKRIKV
160 170 180 190 200
ISKPSKKKQS LKNADLCIAS GTKVALFNRL RSQTVSTRYL HVEGGNFHAS
210 220 230 240 250
SQQWGAFYIH LLDDDESEGE EFTVRDGYIH YGQTVKLVCS VTGMALPRLI
260 270 280 290 300
IRKVDKQTAL LDADDPVSQL HKCAFYLKDT ERMYLCLSQE RIIQFQATPC
310 320 330 340 350
PKEPNKEMIN DGASWTIIST DKAEYTFYEG MGPVLAPVTP VPVVESLQLN
360 370 380 390 400
GGGDVAMLEL TGQNFTPNLR VWFGDVEAET MYRCGESMLC VVPDISAFRE
410 420 430 440 450
GWRWVRQPVQ VPVTLVRNDG IIYSTSLTFT YTPEPGPRPH CSAAGAILRA
460 470 480
NSSQVPPNES NTNSEGSYTN VSTNSTSVTS STATVVS
Length:487
Mass (Da):54,341
Last modified:October 11, 2005 - v1
Checksum:i0EA722EED8647942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103164 mRNA. Translation: AAI03165.1.
RefSeqiNP_001070469.1. NM_001077001.2.
UniGeneiBt.48972.

Genome annotation databases

EnsembliENSBTAT00000004696; ENSBTAP00000004696; ENSBTAG00000003602.
GeneIDi767928.
KEGGibta:767928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103164 mRNA. Translation: AAI03165.1.
RefSeqiNP_001070469.1. NM_001077001.2.
UniGeneiBt.48972.

3D structure databases

ProteinModelPortaliQ3SZ41.
SMRiQ3SZ41. Positions 12-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004696.

Proteomic databases

PaxDbiQ3SZ41.
PRIDEiQ3SZ41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004696; ENSBTAP00000004696; ENSBTAG00000003602.
GeneIDi767928.
KEGGibta:767928.

Organism-specific databases

CTDi3516.

Phylogenomic databases

eggNOGiKOG3743. Eukaryota.
ENOG410XV7K. LUCA.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiQ3SZ41.
KOiK06053.
OMAiVIVILHA.
OrthoDBiEOG7BP826.
TreeFamiTF314117.

Enzyme and pathway databases

ReactomeiR-BTA-2122947. NOTCH1 Intracellular Domain Regulates Transcription.
R-BTA-2197563. NOTCH2 intracellular domain regulates transcription.
R-BTA-350054. Notch-HLH transcription pathway.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SMARTiSM01268. BTD. 1 hit.
SM01267. LAG1_DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiSUH_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.