Q3SZ21 (RPP30_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p30
Short name=RNaseP protein p30
EC=3.1.26.5

Alternative name(s):
RNase P subunit 2

Gene names

Name:	RPP30
Synonyms:	RNASEP2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 268	267	Ribonuclease P protein subunit p30		PRO_0000236681
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	251	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SZ21 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: D61883E7AFAFED73	FASTA	268	29,395
	10 20 30 40 50 60 MAVFADLDLR AGSDLKALRG LVENAAHLGY SVVAINHVVE FKEKKQEIEK PVAVSELFTT 70 80 90 100 110 120 LPIVQGKSKP IKILTRLTII VSDPSHCNVL RATSSRVRLY DIVAVFPKTE KLFHVACTHL 130 140 150 160 170 180 DVDLVCITVT EKLPFYFKRP PINVAIDRGV GFELLYSPAI KDSTMRRYTI SNALNLMQVC 190 200 210 220 230 240 KGKNVIISSA AERPLEIRGP YDVANLGLLF GLSESDAKAA VSTNCRAVLL HGETRKTAFG 250 260 IISTVKKPRT SEADDDSLPA CKKAKCES

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103240 mRNA. Translation: AAI03241.1.
IPI	IPI00713952.
RefSeq	NP_001030538.1. NM_001035461.1.
UniGene	Bt.48969.
3D structure databases
ProteinModelPortal	Q3SZ21.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000003871.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	615098.
KEGG	bta:615098.
Organism-specific databases
CTD	10556.
Phylogenomic databases
eggNOG	COG1603.
HOGENOM	HOG000157793.
HOVERGEN	HBG010226.
InParanoid	Q3SZ21.
KO	K03539.
OrthoDB	EOG4D52Z9.
Family and domain databases
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR002738. RNase_P_p30. [Graphical view]
PANTHER	PTHR13031. PTHR13031. 1 hit.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...
Other
NextBio	20899443.

Entry information

Entry name

RPP30_BOVIN

Accession

Primary (citable) accession number: Q3SZ21

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program