Serine hydroxymethyltransferase, mitochondrial precursor

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Q3SZ20 (GLYM_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 51. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine hydroxymethyltransferase, mitochondrial
Short name=SHMT
EC=2.1.2.1

Alternative name(s):
Glycine hydroxymethyltransferase
Serine methylase

Gene names

Name:

SHMT2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H₂O = tetrahydrofolate + L-serine.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion By similarity. Mitochondrion matrix › mitochondrion nucleoid By similarity. Mitochondrion inner membrane By similarity.
Miscellaneous	In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane Mitochondrion nucleoid
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Methyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial inner membrane Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial nucleoid Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: EC methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 29

Mitochondrion By similarity

Chain

30 – 504

475

Serine hydroxymethyltransferase, mitochondrial

PRO_0000239655

Amino acid modifications

Modified residue

103

N6-acetyllysine By similarity

Modified residue

181

N6-acetyllysine By similarity

Modified residue

196

N6-acetyllysine By similarity

Modified residue

269

N6-acetyllysine By similarity

Modified residue

280

N6-(pyridoxal phosphate)lysine By similarity

Modified residue

356

N6-acetyllysine By similarity

Modified residue

464

N6-acetyllysine By similarity

Modified residue

469

N6-acetyllysine By similarity

Modified residue

474

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q3SZ20 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: ED59264587E8B3E6
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FASTA

504

55,605

        10         20         30         40         50         60 
MLSFSFIWAT RPLRRCGQLV GMAVRCQHSE AAQTQTGEAS KGWSGQESLS DSDPEMWELL 

        70         80         90        100        110        120 
RREKDRQCRG LELIASENFC SRAALEALGS CLNNKYSEGY PGKRYYGGAE VVDEIELLCQ 

       130        140        150        160        170        180 
RRALEAFDLD PAQWGVNVQP YSGSPANLAA YTALLQPHDR IMGLDLPDGG HLTHGYMSDV 

       190        200        210        220        230        240 
KRISATSIFF ESMPYKLNPQ TGLIDYDQLA LTARLFKPRL IIAGTSAYAR LIDYARMREV 

       250        260        270        280        290        300 
CDEVKAHLLA DMAHISGLVA AKVIPSPFKH ADIVTTTTHK TLRGARSGLI FYRKGVQAVD 

       310        320        330        340        350        360 
PKTGREIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY SLQILKNAQA 

       370        380        390        400        410        420 
MANALLERGY SLVSGGTDNH LVLVDLRPKG LDGARAERVL ELVSITANKN TCPGDRSAIT 

       430        440        450        460        470        480 
PGGLRLGAPA LTSRGFLEDD FRKVVGFIDE GVNIGLEVKS KTTKLQDFKS FLLKDPETSH 

       490        500 
QLADLRQRVE QFARAFPMPG FDDH

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References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103242 mRNA. Translation: AAI03243.1.
IPI	IPI00718654.
RefSeq	NP_001029454.1. NM_001034282.1.
UniGene	Bt.49106.
3D structure databases
ProteinModelPortal	Q3SZ20.
SMR	Q3SZ20. Positions 42-504.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SZ20.
Proteomic databases
PRIDE	Q3SZ20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000038244; ENSBTAP00000038059; ENSBTAG00000031500.
GeneID	507197.
KEGG	bta:507197.
Organism-specific databases
CTD	6472.
Phylogenomic databases
eggNOG	maNOG16919.
GeneTree	ENSGT00390000002762.
HOVERGEN	HBG002807.
InParanoid	Q3SZ20.
OMA	KDSETSQ.
OrthoDB	EOG4G4GQ7.
PhylomeDB	Q3SZ20.
Family and domain databases
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00600.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYM_BOVIN

Accession

Primary (citable) accession number: Q3SZ20

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents