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Protein

Xylulose kinase

Gene

XYLB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei280 – 2801SubstrateBy similarity
Binding sitei281 – 2811SubstrateBy similarity
Binding sitei355 – 3551ATPBy similarity
Binding sitei445 – 4451ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi441 – 4422ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. D-xylose metabolic process Source: UniProtKB-KW
  3. xylulose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13243.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:XYLB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Xylulose kinasePRO_0000230984Add
BLAST

Proteomic databases

PRIDEiQ3SYZ6.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030820.

Structurei

3D structure databases

ProteinModelPortaliQ3SYZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiQ3SYZ6.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG751NFS.
TreeFamiTF313643.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAERAARHCC LGWDFSTQQV KVVAVDAELS VFYEDSVHFD RDLVEFGTQG
60 70 80 90 100
GVHVHKDGLT VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG
110 120 130 140 150
SVYWKTGASQ VLTSLSPDLP LREQLQACFS ISNCPVWMDS STAAQCRQLE
160 170 180 190 200
AAVGGAQALS LLTGSRAYER FTGNQIAKIY QQNPEAYSHT ERISLVSSFA
210 220 230 240 250
ASLFLGSYSP VDYSDGSGMN LLQIQDKVWS QACLGACAPR LEEKLGRPVP
260 270 280 290 300
SCSIVGAISS YFVQRYGFPP ECKVVAFTGD NPASLAGMRL EEGDIAVSLG
310 320 330 340 350
TSDTLFLWLQ EPTPALEGHI FCNPVDPQHY MALLCFKNGS LMREKIRDES
360 370 380 390 400
ASGSWSKFSK ALQSTGMGNS GNLGFYFDVM EITPEIIGRH RFTAENHEVS
410 420 430 440 450
AFPQDVEIRA LIEGQFMAKK IHAEALGYRV MPKTKILATG GASHNRDILQ
460 470 480 490
VLADVFGAPV YVIDTANSAC VGSAYRAFHG PSLLCLVSIY
Length:490
Mass (Da):53,305
Last modified:October 11, 2005 - v1
Checksum:iC681FED9E37A01F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103316 mRNA. Translation: AAI03317.1.
RefSeqiNP_001029655.1. NM_001034483.1.
UniGeneiBt.17735.

Genome annotation databases

EnsembliENSBTAT00000030851; ENSBTAP00000030820; ENSBTAG00000011278.
GeneIDi515146.
KEGGibta:515146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103316 mRNA. Translation: AAI03317.1.
RefSeqiNP_001029655.1. NM_001034483.1.
UniGeneiBt.17735.

3D structure databases

ProteinModelPortaliQ3SYZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030820.

Proteomic databases

PRIDEiQ3SYZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000030851; ENSBTAP00000030820; ENSBTAG00000011278.
GeneIDi515146.
KEGGibta:515146.

Organism-specific databases

CTDi9942.

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiQ3SYZ6.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG751NFS.
TreeFamiTF313643.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13243.

Miscellaneous databases

NextBioi20871683.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiXYLB_BOVIN
AccessioniPrimary (citable) accession number: Q3SYZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.