Reviewed, UniProtKB/Swiss-Prot Q3SYY2 (TPST2_BOVIN)

Names and origin

Protein names

Recommended name:
    Protein-tyrosine sulfotransferase 2
    EC=2.8.2.20
Alternative name(s):
    Tyrosylprotein sulfotransferase-2
      Short name=TPST-2

Gene names

Name:

TPST2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides By similarity.
Catalytic activity	3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the protein sulfotransferase family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein-tyrosine sulfotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Protein-tyrosine sulfotransferase 2		PRO_0000253723
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Signal-anchor for type II membrane protein Potential
	Topological domain	26 – 377	352	Lumenal Potential
Amino acid modifications
	Glycosylation	343	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3SYY2-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 9DC99F2A9D4288D8	FASTA	377	41,967
	10 20 30 40 50 60 MRLSMRRALL AAGLALALVL AVHLGQRVLE CQAVLGGPRG PRRTMRPEQE DLMMVGADHV 70 80 90 100 110 120 EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK 130 140 150 160 170 180 LRLDEAGVTD EVLDAAMQAF ILEVIAKHGE PARVLCNKDP FTLKSSVYLS RLFPNSKFLL 190 200 210 220 230 240 MVRDGRASVH SMITRKVTIA GFDLSSYRDC LTKWNKAIEV MYAQCMEVGR DKCLPVYYEQ 250 260 270 280 290 300 LVLHPRRSLK VILDFLGIAW SDAVLHHEDL IGKPGGVSLS KIERSTDQVI KPVNLEALSK 310 320 330 340 350 360 WTGHIPGDVL RDMAQIAPML ARLGYDPYAN PPNYGNPDPI VINNTHRVLK GDYKTPANLK 370 GYFQVNLNST SSHLGSS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103334 mRNA. Translation: AAI03335.1.
IPI	IPI00702070.
RefSeq	NP_001030506.1.
UniGene	Bt.65031
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000013685; ENSBTAP00000013685; ENSBTAG00000010368; Bos taurus. [Genome view]
GeneID	540183.
KEGG	bta:540183.
Organism-specific databases
CTD	540183.
Phylogenomic databases
eggNOG	maNOG04352.
HOVERGEN	Q3SYY2.
InParanoid	Q3SYY2.
Enzyme and pathway databases
BRENDA	2.8.2.20. 251.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

TPST2_BOVIN

Accession

Primary (citable) accession number: Q3SYY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 11, 2005
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)