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Q3SYX9

- ARPC5_BOVIN

UniProt

Q3SYX9 - ARPC5_BOVIN

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Protein

Actin-related protein 2/3 complex subunit 5

Gene
ARPC5
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

GO - Biological processi

  1. regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARPC5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
  3. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 151150Actin-related protein 2/3 complex subunit 5PRO_0000246172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation By similarity.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PRIDEiQ3SYX9.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29795N.

Structurei

Secondary structure

1
151
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 123
Helixi16 – 194
Beta strandi21 – 233
Helixi39 – 479
Helixi51 – 588
Beta strandi59 – 613
Helixi69 – 8517
Helixi88 – 903
Helixi91 – 966
Helixi100 – 11415
Helixi121 – 14525

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00G1-151[»]
1TYQX-ray2.55G1-151[»]
1U2VX-ray2.55G1-151[»]
2P9IX-ray2.46G1-151[»]
2P9KX-ray2.59G1-151[»]
2P9LX-ray2.65G1-151[»]
2P9NX-ray2.85G1-151[»]
2P9PX-ray2.90G1-151[»]
2P9SX-ray2.68G1-151[»]
2P9UX-ray2.75G1-151[»]
3DXKX-ray2.70G1-151[»]
3DXMX-ray2.85G1-151[»]
3RSEX-ray2.65G1-151[»]
3UKRX-ray2.48G1-151[»]
3UKUX-ray2.75G1-151[»]
3ULEX-ray2.50G1-151[»]
4JD2X-ray3.08G1-151[»]
ProteinModelPortaliQ3SYX9.
SMRiQ3SYX9. Positions 9-150.

Miscellaneous databases

EvolutionaryTraceiQ3SYX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.

Phylogenomic databases

HOVERGENiHBG050583.
KOiK05754.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARP2/3_p16_Arc.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYX9-1 [UniParc]FASTAAdd to Basket

« Hide

MSKNTVSSAR FRKVDVGEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN    50
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK 100
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT 150
V 151
Length:151
Mass (Da):16,230
Last modified:January 23, 2007 - v3
Checksum:iF39FB10DC68E6F79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103337 mRNA. Translation: AAI03338.1.
RefSeqiNP_001030524.1. NM_001035447.2.
UniGeneiBt.8254.

Genome annotation databases

GeneIDi614345.
KEGGibta:614345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103337 mRNA. Translation: AAI03338.1 .
RefSeqi NP_001030524.1. NM_001035447.2.
UniGenei Bt.8254.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 G 1-151 [» ]
1TYQ X-ray 2.55 G 1-151 [» ]
1U2V X-ray 2.55 G 1-151 [» ]
2P9I X-ray 2.46 G 1-151 [» ]
2P9K X-ray 2.59 G 1-151 [» ]
2P9L X-ray 2.65 G 1-151 [» ]
2P9N X-ray 2.85 G 1-151 [» ]
2P9P X-ray 2.90 G 1-151 [» ]
2P9S X-ray 2.68 G 1-151 [» ]
2P9U X-ray 2.75 G 1-151 [» ]
3DXK X-ray 2.70 G 1-151 [» ]
3DXM X-ray 2.85 G 1-151 [» ]
3RSE X-ray 2.65 G 1-151 [» ]
3UKR X-ray 2.48 G 1-151 [» ]
3UKU X-ray 2.75 G 1-151 [» ]
3ULE X-ray 2.50 G 1-151 [» ]
4JD2 X-ray 3.08 G 1-151 [» ]
ProteinModelPortali Q3SYX9.
SMRi Q3SYX9. Positions 9-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29795N.

Proteomic databases

PRIDEi Q3SYX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 614345.
KEGGi bta:614345.

Organism-specific databases

CTDi 10092.

Phylogenomic databases

HOVERGENi HBG050583.
KOi K05754.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q3SYX9.
NextBioi 20899066.

Family and domain databases

Gene3Di 1.25.40.190. 1 hit.
InterProi IPR006789. ARP2/3_p16_Arc.
[Graphical view ]
PANTHERi PTHR12644. PTHR12644. 1 hit.
Pfami PF04699. P16-Arc. 1 hit.
[Graphical view ]
SUPFAMi SSF69103. SSF69103. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC5_BOVIN
AccessioniPrimary (citable) accession number: Q3SYX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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