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Q3SYX9

- ARPC5_BOVIN

UniProt

Q3SYX9 - ARPC5_BOVIN

Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARPC5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

    GO - Biological processi

    1. regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Alternative name(s):
    Arp2/3 complex 16 kDa subunit
    Short name:
    p16-ARC
    Gene namesi
    Name:ARPC5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell projection By similarity

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 151150Actin-related protein 2/3 complex subunit 5PRO_0000246172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Post-translational modificationi

    Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    PRIDEiQ3SYX9.

    Interactioni

    Subunit structurei

    Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Protein-protein interaction databases

    DIPiDIP-29795N.

    Structurei

    Secondary structure

    1
    151
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 123
    Helixi16 – 194
    Beta strandi21 – 233
    Helixi39 – 479
    Helixi51 – 588
    Beta strandi59 – 613
    Helixi69 – 8517
    Helixi88 – 903
    Helixi91 – 966
    Helixi100 – 11415
    Helixi121 – 14525

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K8KX-ray2.00G1-151[»]
    1TYQX-ray2.55G1-151[»]
    1U2VX-ray2.55G1-151[»]
    2P9IX-ray2.46G1-151[»]
    2P9KX-ray2.59G1-151[»]
    2P9LX-ray2.65G1-151[»]
    2P9NX-ray2.85G1-151[»]
    2P9PX-ray2.90G1-151[»]
    2P9SX-ray2.68G1-151[»]
    2P9UX-ray2.75G1-151[»]
    3DXKX-ray2.70G1-151[»]
    3DXMX-ray2.85G1-151[»]
    3RSEX-ray2.65G1-151[»]
    3UKRX-ray2.48G1-151[»]
    3UKUX-ray2.75G1-151[»]
    3ULEX-ray2.50G1-151[»]
    4JD2X-ray3.08G1-151[»]
    ProteinModelPortaliQ3SYX9.
    SMRiQ3SYX9. Positions 9-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3SYX9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARPC5 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050583.
    KOiK05754.

    Family and domain databases

    Gene3Di1.25.40.190. 1 hit.
    InterProiIPR006789. ARP2/3_p16_Arc.
    [Graphical view]
    PANTHERiPTHR12644. PTHR12644. 1 hit.
    PfamiPF04699. P16-Arc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69103. SSF69103. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SYX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNTVSSAR FRKVDVGEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN    50
    MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK 100
    NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT 150
    V 151
    Length:151
    Mass (Da):16,230
    Last modified:January 23, 2007 - v3
    Checksum:iF39FB10DC68E6F79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103337 mRNA. Translation: AAI03338.1.
    RefSeqiNP_001030524.1. NM_001035447.2.
    UniGeneiBt.8254.

    Genome annotation databases

    GeneIDi614345.
    KEGGibta:614345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103337 mRNA. Translation: AAI03338.1 .
    RefSeqi NP_001030524.1. NM_001035447.2.
    UniGenei Bt.8254.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K8K X-ray 2.00 G 1-151 [» ]
    1TYQ X-ray 2.55 G 1-151 [» ]
    1U2V X-ray 2.55 G 1-151 [» ]
    2P9I X-ray 2.46 G 1-151 [» ]
    2P9K X-ray 2.59 G 1-151 [» ]
    2P9L X-ray 2.65 G 1-151 [» ]
    2P9N X-ray 2.85 G 1-151 [» ]
    2P9P X-ray 2.90 G 1-151 [» ]
    2P9S X-ray 2.68 G 1-151 [» ]
    2P9U X-ray 2.75 G 1-151 [» ]
    3DXK X-ray 2.70 G 1-151 [» ]
    3DXM X-ray 2.85 G 1-151 [» ]
    3RSE X-ray 2.65 G 1-151 [» ]
    3UKR X-ray 2.48 G 1-151 [» ]
    3UKU X-ray 2.75 G 1-151 [» ]
    3ULE X-ray 2.50 G 1-151 [» ]
    4JD2 X-ray 3.08 G 1-151 [» ]
    ProteinModelPortali Q3SYX9.
    SMRi Q3SYX9. Positions 9-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29795N.

    Proteomic databases

    PRIDEi Q3SYX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 614345.
    KEGGi bta:614345.

    Organism-specific databases

    CTDi 10092.

    Phylogenomic databases

    HOVERGENi HBG050583.
    KOi K05754.

    Enzyme and pathway databases

    Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    EvolutionaryTracei Q3SYX9.
    NextBioi 20899066.

    Family and domain databases

    Gene3Di 1.25.40.190. 1 hit.
    InterProi IPR006789. ARP2/3_p16_Arc.
    [Graphical view ]
    PANTHERi PTHR12644. PTHR12644. 1 hit.
    Pfami PF04699. P16-Arc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69103. SSF69103. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
    3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
      Nolen B.J., Littlefield R.S., Pollard T.D.
      Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

    Entry informationi

    Entry nameiARPC5_BOVIN
    AccessioniPrimary (citable) accession number: Q3SYX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3