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Q3SYX9

- ARPC5_BOVIN

UniProt

Q3SYX9 - ARPC5_BOVIN

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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARPC5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

  1. regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARPC5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 151150Actin-related protein 2/3 complex subunit 5PRO_0000246172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PRIDEiQ3SYX9.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29795N.

Structurei

Secondary structure

1
151
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 123
Helixi16 – 194
Beta strandi21 – 233
Helixi39 – 479
Helixi51 – 588
Beta strandi59 – 613
Helixi69 – 8517
Helixi88 – 903
Helixi91 – 966
Helixi100 – 11415
Helixi121 – 14525

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00G1-151[»]
1TYQX-ray2.55G1-151[»]
1U2VX-ray2.55G1-151[»]
2P9IX-ray2.46G1-151[»]
2P9KX-ray2.59G1-151[»]
2P9LX-ray2.65G1-151[»]
2P9NX-ray2.85G1-151[»]
2P9PX-ray2.90G1-151[»]
2P9SX-ray2.68G1-151[»]
2P9UX-ray2.75G1-151[»]
3DXKX-ray2.70G1-151[»]
3DXMX-ray2.85G1-151[»]
3RSEX-ray2.65G1-151[»]
3UKRX-ray2.48G1-151[»]
3UKUX-ray2.75G1-151[»]
3ULEX-ray2.50G1-151[»]
4JD2X-ray3.08G1-151[»]
ProteinModelPortaliQ3SYX9.
SMRiQ3SYX9. Positions 9-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3SYX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

HOVERGENiHBG050583.
InParanoidiQ3SYX9.
KOiK05754.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARP2/3_p16_Arc.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVGEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,230
Last modified:January 23, 2007 - v3
Checksum:iF39FB10DC68E6F79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103337 mRNA. Translation: AAI03338.1.
RefSeqiNP_001030524.1. NM_001035447.2.
UniGeneiBt.8254.

Genome annotation databases

GeneIDi614345.
KEGGibta:614345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103337 mRNA. Translation: AAI03338.1 .
RefSeqi NP_001030524.1. NM_001035447.2.
UniGenei Bt.8254.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 G 1-151 [» ]
1TYQ X-ray 2.55 G 1-151 [» ]
1U2V X-ray 2.55 G 1-151 [» ]
2P9I X-ray 2.46 G 1-151 [» ]
2P9K X-ray 2.59 G 1-151 [» ]
2P9L X-ray 2.65 G 1-151 [» ]
2P9N X-ray 2.85 G 1-151 [» ]
2P9P X-ray 2.90 G 1-151 [» ]
2P9S X-ray 2.68 G 1-151 [» ]
2P9U X-ray 2.75 G 1-151 [» ]
3DXK X-ray 2.70 G 1-151 [» ]
3DXM X-ray 2.85 G 1-151 [» ]
3RSE X-ray 2.65 G 1-151 [» ]
3UKR X-ray 2.48 G 1-151 [» ]
3UKU X-ray 2.75 G 1-151 [» ]
3ULE X-ray 2.50 G 1-151 [» ]
4JD2 X-ray 3.08 G 1-151 [» ]
ProteinModelPortali Q3SYX9.
SMRi Q3SYX9. Positions 9-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29795N.

Proteomic databases

PRIDEi Q3SYX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 614345.
KEGGi bta:614345.

Organism-specific databases

CTDi 10092.

Phylogenomic databases

HOVERGENi HBG050583.
InParanoidi Q3SYX9.
KOi K05754.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q3SYX9.
NextBioi 20899066.

Family and domain databases

Gene3Di 1.25.40.190. 1 hit.
InterProi IPR006789. ARP2/3_p16_Arc.
[Graphical view ]
PANTHERi PTHR12644. PTHR12644. 1 hit.
Pfami PF04699. P16-Arc. 1 hit.
[Graphical view ]
SUPFAMi SSF69103. SSF69103. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC5_BOVIN
AccessioniPrimary (citable) accession number: Q3SYX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3