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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARPC5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARPC5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002461722 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ3SYX9.
PeptideAtlasiQ3SYX9.
PRIDEiQ3SYX9.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29795N.
STRINGi9913.ENSBTAP00000054193.

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 12Combined sources3
Helixi16 – 19Combined sources4
Beta strandi21 – 23Combined sources3
Helixi39 – 47Combined sources9
Helixi51 – 58Combined sources8
Beta strandi59 – 61Combined sources3
Helixi69 – 85Combined sources17
Helixi88 – 90Combined sources3
Helixi91 – 96Combined sources6
Helixi100 – 114Combined sources15
Helixi121 – 145Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00G1-151[»]
1TYQX-ray2.55G1-151[»]
1U2VX-ray2.55G1-151[»]
2P9IX-ray2.46G1-151[»]
2P9KX-ray2.59G1-151[»]
2P9LX-ray2.65G1-151[»]
2P9NX-ray2.85G1-151[»]
2P9PX-ray2.90G1-151[»]
2P9SX-ray2.68G1-151[»]
2P9UX-ray2.75G1-151[»]
3DXKX-ray2.70G1-151[»]
3DXMX-ray2.85G1-151[»]
3RSEX-ray2.65G1-151[»]
3UKRX-ray2.48G1-151[»]
3UKUX-ray2.75G1-151[»]
3ULEX-ray2.50G1-151[»]
4JD2X-ray3.08G1-151[»]
4XEIX-ray3.87G1-151[»]
4XF2X-ray5.00G/Z1-151[»]
ProteinModelPortaliQ3SYX9.
SMRiQ3SYX9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3SYX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
HOVERGENiHBG050583.
InParanoidiQ3SYX9.
KOiK05754.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVGEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,230
Last modified:January 23, 2007 - v3
Checksum:iF39FB10DC68E6F79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103337 mRNA. Translation: AAI03338.1.
RefSeqiNP_001030524.1. NM_001035447.2.
UniGeneiBt.8254.

Genome annotation databases

GeneIDi614345.
KEGGibta:614345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103337 mRNA. Translation: AAI03338.1.
RefSeqiNP_001030524.1. NM_001035447.2.
UniGeneiBt.8254.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00G1-151[»]
1TYQX-ray2.55G1-151[»]
1U2VX-ray2.55G1-151[»]
2P9IX-ray2.46G1-151[»]
2P9KX-ray2.59G1-151[»]
2P9LX-ray2.65G1-151[»]
2P9NX-ray2.85G1-151[»]
2P9PX-ray2.90G1-151[»]
2P9SX-ray2.68G1-151[»]
2P9UX-ray2.75G1-151[»]
3DXKX-ray2.70G1-151[»]
3DXMX-ray2.85G1-151[»]
3RSEX-ray2.65G1-151[»]
3UKRX-ray2.48G1-151[»]
3UKUX-ray2.75G1-151[»]
3ULEX-ray2.50G1-151[»]
4JD2X-ray3.08G1-151[»]
4XEIX-ray3.87G1-151[»]
4XF2X-ray5.00G/Z1-151[»]
ProteinModelPortaliQ3SYX9.
SMRiQ3SYX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29795N.
STRINGi9913.ENSBTAP00000054193.

Proteomic databases

PaxDbiQ3SYX9.
PeptideAtlasiQ3SYX9.
PRIDEiQ3SYX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi614345.
KEGGibta:614345.

Organism-specific databases

CTDi10092.

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
HOVERGENiHBG050583.
InParanoidiQ3SYX9.
KOiK05754.

Miscellaneous databases

EvolutionaryTraceiQ3SYX9.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC5_BOVIN
AccessioniPrimary (citable) accession number: Q3SYX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.