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Q3SYX9 (ARPC5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name=p16-ARC
Gene names
Name:ARPC5
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Cell projection By similarity.

Sequence similarities

Belongs to the ARPC5 family.

Ontologies

Keywords
   Cellular componentCell projection
Cytoplasm
Cytoskeleton
   LigandActin-binding
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of actin filament polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell projection

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 151150Actin-related protein 2/3 complex subunit 5
PRO_0000246172

Secondary structure

1 ..................... 151
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q3SYX9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F39FB10DC68E6F79

FASTA15116,230
        10         20         30         40         50         60 
MSKNTVSSAR FRKVDVGEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK 

        70         80         90        100        110        120 
NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN 

       130        140        150 
SSAVLLQWHE KALAAGGVGS IVRVLTARKT V

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[2]"Crystal structure of Arp2/3 complex."
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N., Choe S., Pollard T.D.
Science 294:1679-1684(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
[3]"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
Nolen B.J., Littlefield R.S., Pollard T.D.
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC103337 mRNA. Translation: AAI03338.1.
IPIIPI00716307.
RefSeqNP_001030524.1. NM_001035447.2.
UniGeneBt.8254.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00G1-151[»]
1TYQX-ray2.55G1-151[»]
1U2VX-ray2.55G1-151[»]
2P9IX-ray2.46G1-151[»]
2P9KX-ray2.59G1-151[»]
2P9LX-ray2.65G1-151[»]
2P9NX-ray2.85G1-151[»]
2P9PX-ray2.90G1-151[»]
2P9SX-ray2.68G1-151[»]
2P9UX-ray2.75G1-151[»]
3DXKX-ray2.70G1-151[»]
3DXMX-ray2.85G1-151[»]
3RSEX-ray2.65G1-151[»]
3UKRX-ray2.48G1-151[»]
3UKUX-ray2.75G1-151[»]
3ULEX-ray2.50G1-151[»]
ProteinModelPortalQ3SYX9.
SMRQ3SYX9. Positions 9-150.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29795N.

Proteomic databases

PRIDEQ3SYX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID614345.
KEGGbta:614345.

Organism-specific databases

CTD10092.

Phylogenomic databases

HOVERGENHBG050583.
KOK05754.

Family and domain databases

Gene3D1.25.40.190. 1 hit.
InterProIPR006789. ARP2/3_p16_Arc.
[Graphical view]
PANTHERPTHR12644. PTHR12644. 1 hit.
PfamPF04699. P16-Arc. 1 hit.
[Graphical view]
SUPFAMSSF69103. p16_Arc. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ3SYX9.
NextBio20899066.

Entry information

Entry nameARPC5_BOVIN
AccessionPrimary (citable) accession number: Q3SYX9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents