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Reviewed, UniProtKB/Swiss-Prot Q3SYW2 (CO2_BOVIN)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Complement C2
    EC=3.4.21.43
Alternative name(s):
    C3/C5 convertase
Cleaved into the following 2 chains:
    1- Recommended name:
            Complement C2b fragment
    2- Recommended name:
            Complement C2a fragment
Gene names
Name: C2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase By similarity.

Catalytic activity

Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Contains 3 Sushi (CCP/SCR) domains.

Contains 1 VWFA domain.

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Ontologies

Keywords
   Biological processComplement pathway
Immune response
Innate immunity
   Cellular componentSecreted
   DomainRepeat
Signal
Sushi
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processcomplement activation, classical pathway

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 750730Complement C2
PRO_0000236266
Chain21 – 244224Complement C2b fragment By similarity
PRO_0000236267
Chain245 – 750506Complement C2a fragment By similarity
PRO_0000236268

Regions

Domain22 – 8665Sushi 1
Domain87 – 14660Sushi 2
Domain149 – 20658Sushi 3
Domain255 – 453199VWFA
Domain465 – 742278Peptidase S1

Sites

Active site5081Charge relay system By similarity
Active site5621Charge relay system By similarity
Active site6801Charge relay system By similarity

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation6521N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 65 By similarity
Disulfide bond51 ↔ 84 By similarity
Disulfide bond89 ↔ 131 By similarity
Disulfide bond117 ↔ 144 By similarity
Disulfide bond151 ↔ 191 By similarity
Disulfide bond177 ↔ 204 By similarity
Disulfide bond493 ↔ 509 By similarity
Disulfide bond676 ↔ 706 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3SYW2-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 25D199DB5CB43B21

FASTA75082,906
        10         20         30         40         50         60 
MDPLMAVLCL LPLYPGLATA ALSCPKNVNI SGGSFTLSNG WNPGSILTYS CPLGHYPYPV 

        70         80         90        100        110        120 
VTRLCKSNGQ WQIPRSTRST KAICKPVRCP APVSFENGVY IPRLGSHPVG GNLSFECEDG 

       130        140        150        160        170        180 
FTLRGSAVRQ CRPNGMWDGE TAVCDNGASH CPNPGISVGA VRTGSRFGLG DKVRYRCSSN 

       190        200        210        220        230        240 
LVLTGSAERE CQDDGVWSGT EAICRQPYSY DFPEDVAPAL GTSFSHLLAT TNPIQQKKKQ 

       250        260        270        280        290        300 
NLGRKIQIQR SGHLNLYLLL DASQSVSKDD FEIFKDSASR MVDRIFSFEI KVSVAIITFA 

       310        320        330        340        350        360 
SKPKIIMSVL EDRSRDVTEV ENSLRNINYK DHENGTGTNI YEALHAVYIM MNNQMNRPHM 

       370        380        390        400        410        420 
NPGAWQEIRH AIILLTDGKS NMGGSPKVAV DNIKEVLNIN QKRKDYLDIY AIGVGSLHVD 

       430        440        450        460        470        480 
WKELNNLGSK KDGERHAFIL KDVQALSQVF EHMLDVSQLT DPICGVGNMS ANASAQERTP 

       490        500        510        520        530        540 
WHVTIKPKSQ ETCRGALISD QWVLTAAHCF RNAEDRTLWR VSVGDPNFQG SKEFQIEEAV 

       550        560        570        580        590        600 
ISPGFNVFSK KSQGIPEFYG DDIALLKLTQ KVKMSTHARP ICLPCTVGAN LALRKLPGST 

       610        620        630        640        650        660 
CRDHEKELLN QVSIPAHFVA LNGDKLNINL KTGSEWTNCV KVVLKDKTTF PNLTDVREVV 

       670        680        690        700        710        720 
TDQFLCSGTQ GDDSPCKGES GGAVFLERRL RFFQVGLVSW GLYNPCGGSS KNSRKPAPHG 

       730        740        750 
KVPRDFHINL FRLQPWLRQH LEGILNFVPL

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

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Cross-references

Sequence databases

BC103357 mRNA. Translation: AAI03358.1.
IPIIPI00713581.
RefSeqNP_001029664.1.
UniGeneBt.48846

3D structure databases

SMRQ3SYW2. Positions 245-748.
ModBaseSearch...

Genome annotation databases

GeneID515440.
KEGGbta:515440.

Phylogenomic databases

HOVERGENQ3SYW2.

Enzyme and pathway databases

BRENDA3.4.21.43. 251.

Family and domain databases

InterProIPR011360. Compl_C2_B.
IPR016060. Complement_control_module.
IPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP.
IPR002035. VWF_A.
[Graphical view]
Gene3DG3DSA:2.10.70.10. Complement_control_module. 2 hits.
PfamPF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFPIRSF001154. Compl_C2_B. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00032. CCP. 3 hits.
SM00020. Tryp_SPc. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS50923. SUSHI. 3 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCO2_BOVIN
AccessionPrimary (citable) accession number: Q3SYW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents