Q3SYV9 (ARHL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 44.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Poly(ADP-ribose) glycohydrolase ARH3 EC=3.2.1.143 Alternative name(s): ADP-ribosylhydrolase 3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 365 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds By similarity. |
| Catalytic activity | Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the ADP-ribosylglycohydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW poly(ADP-ribose) glycohydrolase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 365 | 365 | Poly(ADP-ribose) glycohydrolase ARH3 | PRO_0000277612 | |||||
Regions | |||||||||
| Compositional bias | 2 – 6 | 5 | Poly-Ala | ||||||
Sites | |||||||||
| Metal binding | 42 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 77 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 78 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 79 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 315 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 317 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 317 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 318 | 1 | Magnesium 2 By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC103360 mRNA. Translation: AAI03361.1. |
| IPI | IPI00692404. |
| RefSeq | NP_001030417.1. NM_001035340.1. |
| UniGene | Bt.51810. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CWC based on UniProtKB Q5SMG9. |
| ProteinModelPortal | Q3SYV9. |
| SMR | Q3SYV9. Positions 19-364. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q3SYV9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 521650. |
| KEGG | bta:521650. |
Organism-specific databases | |
| CTD | 54936. |
Phylogenomic databases | |
| eggNOG | maNOG05037. |
| GeneTree | ENSGT00390000015369. |
| HOVERGEN | HBG080863. |
| InParanoid | Q3SYV9. |
| OrthoDB | EOG466VMC. |
| PhylomeDB | Q3SYV9. |
Family and domain databases | |
| InterPro | IPR005502. Ribosyl_crysJ1. [Graphical view] |
| KO | K11687. |
| Pfam | PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view] |
| SUPFAM | SSF101478. Ribosyl_crysJ1. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ARHL2_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3SYV9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with