Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:CAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002714332 – 472Adenylyl cyclase-associated protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei287N6-methyllysineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3SYV4.
PeptideAtlasiQ3SYV4.
PRIDEiQ3SYV4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013363.

Interactioni

Subunit structurei

Homodimer. Binds actin monomers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017775.

Structurei

3D structure databases

ProteinModelPortaliQ3SYV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 450C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST144

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 256Ala/Pro/Ser-richAdd BLAST39
Compositional biasi230 – 241Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the CAP family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ3SYV4.
KOiK17261.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMRNLVER LERVVGRLEA VSHASDTHCG YGDSAAKAGT TPYVQAFDSL
60 70 80 90 100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAGNK
110 120 130 140 150
LSDLLAPISE QIQEVVTFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP
160 170 180 190 200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF
210 220 230 240 250
HTTGLAWSRT GPVAKELSGL PSGPSAGSGP PPPPPGPPPP PVPTSSGSDD
260 270 280 290 300
SASRSALFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GLIRSGPKPF
310 320 330 340 350
SASKPDPPKP VAKKEPALLE LEGKKWRVEN QENVSNLMIE DTELKQVAYI
360 370 380 390 400
FKCVNSTLQI KGKINSITVD NCKKLGLVFD DVVGIVEIIN SKDVKVQVMG
410 420 430 440 450
KVPTISINKT DGCHVYLSKN SLDCEIVSAK SSEMNVLIPT EGGDFNEFPV
460 470
PEQFKTLWNG QKLVTTVTEI AG
Length:472
Mass (Da):51,273
Last modified:January 23, 2007 - v3
Checksum:i8D164F8B19927E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103366 mRNA. Translation: AAI03367.1.
RefSeqiNP_001030182.1. NM_001035010.2.
XP_005204711.1. XM_005204654.3.
XP_005204712.1. XM_005204655.3.
UniGeneiBt.48990.

Genome annotation databases

GeneIDi504519.
KEGGibta:504519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103366 mRNA. Translation: AAI03367.1.
RefSeqiNP_001030182.1. NM_001035010.2.
XP_005204711.1. XM_005204654.3.
XP_005204712.1. XM_005204655.3.
UniGeneiBt.48990.

3D structure databases

ProteinModelPortaliQ3SYV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017775.

Proteomic databases

PaxDbiQ3SYV4.
PeptideAtlasiQ3SYV4.
PRIDEiQ3SYV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504519.
KEGGibta:504519.

Organism-specific databases

CTDi10487.

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ3SYV4.
KOiK17261.

Gene expression databases

BgeeiENSBTAG00000013363.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAP1_BOVIN
AccessioniPrimary (citable) accession number: Q3SYV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.