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Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:CAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 472471Adenylyl cyclase-associated protein 1PRO_0000271433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei31 – 311PhosphotyrosineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei290 – 2901PhosphoserineBy similarity
Modified residuei295 – 2951PhosphoserineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SYV4.
PRIDEiQ3SYV4.

Interactioni

Subunit structurei

Homodimer. Binds actin monomers (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017775.

Structurei

3D structure databases

ProteinModelPortaliQ3SYV4.
SMRiQ3SYV4. Positions 316-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini307 – 450144C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 25639Ala/Pro/Ser-richAdd
BLAST
Compositional biasi230 – 24112Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the CAP family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ3SYV4.
KOiK17261.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMRNLVER LERVVGRLEA VSHASDTHCG YGDSAAKAGT TPYVQAFDSL
60 70 80 90 100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAGNK
110 120 130 140 150
LSDLLAPISE QIQEVVTFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP
160 170 180 190 200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF
210 220 230 240 250
HTTGLAWSRT GPVAKELSGL PSGPSAGSGP PPPPPGPPPP PVPTSSGSDD
260 270 280 290 300
SASRSALFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GLIRSGPKPF
310 320 330 340 350
SASKPDPPKP VAKKEPALLE LEGKKWRVEN QENVSNLMIE DTELKQVAYI
360 370 380 390 400
FKCVNSTLQI KGKINSITVD NCKKLGLVFD DVVGIVEIIN SKDVKVQVMG
410 420 430 440 450
KVPTISINKT DGCHVYLSKN SLDCEIVSAK SSEMNVLIPT EGGDFNEFPV
460 470
PEQFKTLWNG QKLVTTVTEI AG
Length:472
Mass (Da):51,273
Last modified:January 23, 2007 - v3
Checksum:i8D164F8B19927E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103366 mRNA. Translation: AAI03367.1.
RefSeqiNP_001030182.1. NM_001035010.2.
XP_005204711.1. XM_005204654.3.
XP_005204712.1. XM_005204655.3.
UniGeneiBt.48990.

Genome annotation databases

GeneIDi504519.
KEGGibta:504519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103366 mRNA. Translation: AAI03367.1.
RefSeqiNP_001030182.1. NM_001035010.2.
XP_005204711.1. XM_005204654.3.
XP_005204712.1. XM_005204655.3.
UniGeneiBt.48990.

3D structure databases

ProteinModelPortaliQ3SYV4.
SMRiQ3SYV4. Positions 316-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017775.

Proteomic databases

PaxDbiQ3SYV4.
PRIDEiQ3SYV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504519.
KEGGibta:504519.

Organism-specific databases

CTDi10487.

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ3SYV4.
KOiK17261.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCAP1_BOVIN
AccessioniPrimary (citable) accession number: Q3SYV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.