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Q3SYT8

- NCPR_BOVIN

UniProt

Q3SYT8 - NCPR_BOVIN

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Protein
NADPH--cytochrome P450 reductase
Gene
POR
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 By similarity.

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactori

FAD By similarity.
FMN By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 20132FMN By similarity
Add
BLAST
Nucleotide bindingi314 – 32512FAD By similarity
Add
BLAST
Nucleotide bindingi451 – 46111FAD By similarity
Add
BLAST
Nucleotide bindingi529 – 54719NADP By similarity
Add
BLAST
Nucleotide bindingi624 – 64017NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. NADPH-hemoprotein reductase activity Source: UniProtKB-EC
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. cellular organofluorine metabolic process Source: Ensembl
  2. positive regulation of monooxygenase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductase (EC:1.6.2.4)
Short name:
CPR
Short name:
P450R
Gene namesi
Name:POR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Endoplasmic reticulum membrane; Peripheral membrane protein
Note: Anchored to the ER membrane by its N-terminal hydrophobic region By similarity.

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 678677NADPH--cytochrome P450 reductase
PRO_0000245573Add
BLAST

Proteomic databases

PaxDbiQ3SYT8.
PRIDEiQ3SYT8.

Structurei

3D structure databases

ProteinModelPortaliQ3SYT8.
SMRiQ3SYT8. Positions 64-678.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 224145Flavodoxin-like
Add
BLAST
Domaini279 – 521243FAD-binding FR-type
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Phylogenomic databases

eggNOGiCOG0369.
HOVERGENiHBG000432.
InParanoidiQ3SYT8.
KOiK00327.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYT8-1 [UniParc]FASTAAdd to Basket

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MADSNMDAGT TTSEMVAEEV SLFSTTDVIL FSLIVGVMTY WFLFRKKKEE    50
VPEFTKIQTT TSSVKDRSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK 100
DAHRYGMRGM AADPEEYDLA DLSSLPEIEK ALAIFCMATY GEGDPTDNAQ 150
DFYDWLQETD VDLSGVKYAV FALGNKTYEH FNAMGKYVDK RLEQLGAQRI 200
FDLGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELMVH 250
TDMDMAKVYT GEMGRLKSYE NQKPPFDAKN PFLAVVTTNR KLNQGTERHL 300
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGEILGA DLDIIMSLNN 350
LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPTEHE 400
QLRKMASSSG EGKELYLRWV LEARRHILAI LQDYPSLRPP IDHLCELLPR 450
LQARYYSIAS SSKVHPNSVH ICAVAVEYET KTGRINKGVA TSWLRAKEPA 500
GENGGRALVP MYVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL 550
RQQGKEVGET LLYYGCRRSD EDYLYREELA GFHKDGALTQ LNVAFSREQP 600
QKVYVQHLLK KDKEHLWKLI HEGGAHIYVC GDARNMARDV QNTFYDIVAE 650
QGAMEHAQAV DYVKKLMTKG RYSLDVWS 678
Length:678
Mass (Da):77,021
Last modified:January 23, 2007 - v3
Checksum:iC4103BC020D8842C
GO

Sequence cautioni

The sequence AAI03400.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103399 mRNA. Translation: AAI03400.1. Different initiation.
RefSeqiNP_001030467.1. NM_001035390.1.
UniGeneiBt.41220.

Genome annotation databases

GeneIDi532512.
KEGGibta:532512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103399 mRNA. Translation: AAI03400.1 . Different initiation.
RefSeqi NP_001030467.1. NM_001035390.1.
UniGenei Bt.41220.

3D structure databases

ProteinModelPortali Q3SYT8.
SMRi Q3SYT8. Positions 64-678.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q3SYT8.
PRIDEi Q3SYT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 532512.
KEGGi bta:532512.

Organism-specific databases

CTDi 5447.

Phylogenomic databases

eggNOGi COG0369.
HOVERGENi HBG000432.
InParanoidi Q3SYT8.
KOi K00327.

Miscellaneous databases

NextBioi 20875716.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000208. P450R. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiNCPR_BOVIN
AccessioniPrimary (citable) accession number: Q3SYT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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