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Protein

Calmegin

Gene

CLGN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calmegin
Gene namesi
Name:CLGN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 466LumenalSequence analysisAdd BLAST447
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 606CytoplasmicSequence analysisAdd BLAST119

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000023624520 – 606CalmeginAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124N6-acetyllysineBy similarity1
Disulfide bondi147 ↔ 181By similarity
Disulfide bondi347 ↔ 351By similarity
Modified residuei556PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1
Modified residuei575PhosphoserineBy similarity1
Modified residuei577PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei597PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ3SYT6.
PRIDEiQ3SYT6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001580.

Interactioni

Subunit structurei

Interacts with PPIB and PDILT. Interacts with ADAM2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002071.

Structurei

3D structure databases

ProteinModelPortaliQ3SYT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati263 – 2761-1Add BLAST14
Repeati280 – 2931-2Add BLAST14
Repeati299 – 3121-3Add BLAST14
Repeati318 – 3311-4Add BLAST14
Repeati335 – 3482-1Add BLAST14
Repeati352 – 3652-2Add BLAST14
Repeati366 – 3792-3Add BLAST14
Repeati380 – 3932-4Add BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni313 – 346Interaction with PPIBBy similarityAdd BLAST34

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
GeneTreeiENSGT00430000030841.
HOVERGENiHBG005407.
InParanoidiQ3SYT6.
KOiK09551.
OMAiPACRIGC.
OrthoDBiEOG091G04SS.
TreeFamiTF300618.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 2 hits.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFQGFWLCL GLLFISVNAE FMDDSVEMED FDENSEETDE LSSEIKYKTP
60 70 80 90 100
QPVGEVYFTE TFDSGRLAGW VLSKAKKDDI DAEISIYDGR WEIEELKENR
110 120 130 140 150
IPGDRGLVLK SRAKHHAISA VLAKPFIFAD KPLVVQYEVN FQDGIDCGGA
160 170 180 190 200
YIKLLADTDG LNLENFYDKT SYTIMFGPDK CGEDYKLHFI FRHKHPKTGV
210 220 230 240 250
FEEKHAKPPD VDLKRFFTDR KTHLYTLVMN PDDTFEVLID QIVVNKGSLL
260 270 280 290 300
EDVVPPINPP KEIEDPTDEK PDDWDERAKI PDASAVKPED WDESEPPQIV
310 320 330 340 350
DSSAVKPDGW LDNEPEFIPD PNAEKPFDWN EDMDGEWEAP HISNPACRIG
360 370 380 390 400
CGEWSPPMID NPKYKGIWRP PMIDNPNYQG IWSPRKIPNP DYFEDNHPFL
410 420 430 440 450
LTSFRALGLE LWSMTSDIYF DNFIICSEKE VADRWAADGW GMKILIENAN
460 470 480 490 500
EPSIFKQLMS ATEQRPWLWF IYLLTAALPI ALIGSFCWPR KVKKKYEDVA
510 520 530 540 550
FEKLDICKPQ TKGALEQEVK EEKAALEKPV DLEEEKKQSD GEIVEKEEEG
560 570 580 590 600
EPEEKSEEEI EIIEGQEEGN KSNKSGSEDE MKEADESTGS GDGPIKSVRK

RRVRKE
Length:606
Mass (Da):69,515
Last modified:October 11, 2005 - v1
Checksum:i4FAE7CE2EBF8EB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103401 mRNA. Translation: AAI03402.1.
RefSeqiNP_001029377.1. NM_001034205.2.
UniGeneiBt.17314.

Genome annotation databases

EnsembliENSBTAT00000002071; ENSBTAP00000002071; ENSBTAG00000001580.
GeneIDi504256.
KEGGibta:504256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103401 mRNA. Translation: AAI03402.1.
RefSeqiNP_001029377.1. NM_001034205.2.
UniGeneiBt.17314.

3D structure databases

ProteinModelPortaliQ3SYT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002071.

Proteomic databases

PaxDbiQ3SYT6.
PRIDEiQ3SYT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002071; ENSBTAP00000002071; ENSBTAG00000001580.
GeneIDi504256.
KEGGibta:504256.

Organism-specific databases

CTDi1047.

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
GeneTreeiENSGT00430000030841.
HOVERGENiHBG005407.
InParanoidiQ3SYT6.
KOiK09551.
OMAiPACRIGC.
OrthoDBiEOG091G04SS.
TreeFamiTF300618.

Gene expression databases

BgeeiENSBTAG00000001580.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 2 hits.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLGN_BOVIN
AccessioniPrimary (citable) accession number: Q3SYT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.