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Q3SYT6

- CLGN_BOVIN

UniProt

Q3SYT6 - CLGN_BOVIN

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Protein

Calmegin

Gene
CLGN
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. binding of sperm to zona pellucida Source: Ensembl
  2. protein complex assembly Source: Ensembl
  3. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calmegin
Gene namesi
Name:CLGN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 466447Lumenal Reviewed predictionAdd
BLAST
Transmembranei467 – 48721Helical; Reviewed predictionAdd
BLAST
Topological domaini488 – 606119Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear envelope Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 606587CalmeginPRO_0000236245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi147 ↔ 181 By similarity
Disulfide bondi347 ↔ 351 By similarity
Modified residuei556 – 5561Phosphoserine By similarity
Modified residuei572 – 5721Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiQ3SYT6.

Interactioni

Subunit structurei

Interacts with PPIB and PDILT. Interacts with ADAM2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3SYT6.
SMRiQ3SYT6. Positions 47-442.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati263 – 276141-1Add
BLAST
Repeati280 – 293141-2Add
BLAST
Repeati299 – 312141-3Add
BLAST
Repeati318 – 331141-4Add
BLAST
Repeati335 – 348142-1Add
BLAST
Repeati352 – 365142-2Add
BLAST
Repeati366 – 379142-3Add
BLAST
Repeati380 – 393142-4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni313 – 34634Interaction with PPIB By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the calreticulin family.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305105.
GeneTreeiENSGT00430000030841.
HOVERGENiHBG005407.
InParanoidiQ3SYT6.
KOiK09551.
OMAiEEKHAKP.
OrthoDBiEOG77126Z.
TreeFamiTF300618.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYT6-1 [UniParc]FASTAAdd to Basket

« Hide

MRFQGFWLCL GLLFISVNAE FMDDSVEMED FDENSEETDE LSSEIKYKTP    50
QPVGEVYFTE TFDSGRLAGW VLSKAKKDDI DAEISIYDGR WEIEELKENR 100
IPGDRGLVLK SRAKHHAISA VLAKPFIFAD KPLVVQYEVN FQDGIDCGGA 150
YIKLLADTDG LNLENFYDKT SYTIMFGPDK CGEDYKLHFI FRHKHPKTGV 200
FEEKHAKPPD VDLKRFFTDR KTHLYTLVMN PDDTFEVLID QIVVNKGSLL 250
EDVVPPINPP KEIEDPTDEK PDDWDERAKI PDASAVKPED WDESEPPQIV 300
DSSAVKPDGW LDNEPEFIPD PNAEKPFDWN EDMDGEWEAP HISNPACRIG 350
CGEWSPPMID NPKYKGIWRP PMIDNPNYQG IWSPRKIPNP DYFEDNHPFL 400
LTSFRALGLE LWSMTSDIYF DNFIICSEKE VADRWAADGW GMKILIENAN 450
EPSIFKQLMS ATEQRPWLWF IYLLTAALPI ALIGSFCWPR KVKKKYEDVA 500
FEKLDICKPQ TKGALEQEVK EEKAALEKPV DLEEEKKQSD GEIVEKEEEG 550
EPEEKSEEEI EIIEGQEEGN KSNKSGSEDE MKEADESTGS GDGPIKSVRK 600
RRVRKE 606
Length:606
Mass (Da):69,515
Last modified:October 11, 2005 - v1
Checksum:i4FAE7CE2EBF8EB4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103401 mRNA. Translation: AAI03402.1.
RefSeqiNP_001029377.1. NM_001034205.2.
UniGeneiBt.17314.

Genome annotation databases

EnsembliENSBTAT00000002071; ENSBTAP00000002071; ENSBTAG00000001580.
GeneIDi504256.
KEGGibta:504256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103401 mRNA. Translation: AAI03402.1 .
RefSeqi NP_001029377.1. NM_001034205.2.
UniGenei Bt.17314.

3D structure databases

ProteinModelPortali Q3SYT6.
SMRi Q3SYT6. Positions 47-442.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q3SYT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002071 ; ENSBTAP00000002071 ; ENSBTAG00000001580 .
GeneIDi 504256.
KEGGi bta:504256.

Organism-specific databases

CTDi 1047.

Phylogenomic databases

eggNOGi NOG305105.
GeneTreei ENSGT00430000030841.
HOVERGENi HBG005407.
InParanoidi Q3SYT6.
KOi K09551.
OMAi EEKHAKP.
OrthoDBi EOG77126Z.
TreeFami TF300618.

Miscellaneous databases

NextBioi 20866586.

Family and domain databases

Gene3Di 2.10.250.10. 1 hit.
2.60.120.200. 2 hits.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCLGN_BOVIN
AccessioniPrimary (citable) accession number: Q3SYT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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