Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3SYT6

- CLGN_BOVIN

UniProt

Q3SYT6 - CLGN_BOVIN

Protein

Calmegin

Gene

CLGN

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. binding of sperm to zona pellucida Source: Ensembl
    2. protein complex assembly Source: Ensembl
    3. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calmegin
    Gene namesi
    Name:CLGN
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear envelope Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 606587CalmeginPRO_0000236245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi147 ↔ 181By similarity
    Disulfide bondi347 ↔ 351By similarity
    Modified residuei556 – 5561PhosphoserineBy similarity
    Modified residuei572 – 5721PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiQ3SYT6.

    Interactioni

    Subunit structurei

    Interacts with PPIB and PDILT. Interacts with ADAM2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SYT6.
    SMRiQ3SYT6. Positions 47-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 466447LumenalSequence AnalysisAdd
    BLAST
    Topological domaini488 – 606119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati263 – 276141-1Add
    BLAST
    Repeati280 – 293141-2Add
    BLAST
    Repeati299 – 312141-3Add
    BLAST
    Repeati318 – 331141-4Add
    BLAST
    Repeati335 – 348142-1Add
    BLAST
    Repeati352 – 365142-2Add
    BLAST
    Repeati366 – 379142-3Add
    BLAST
    Repeati380 – 393142-4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni313 – 34634Interaction with PPIBBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calreticulin family.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305105.
    GeneTreeiENSGT00430000030841.
    HOVERGENiHBG005407.
    InParanoidiQ3SYT6.
    KOiK09551.
    OMAiEEKHAKP.
    OrthoDBiEOG77126Z.
    TreeFamiTF300618.

    Family and domain databases

    Gene3Di2.10.250.10. 1 hit.
    2.60.120.200. 2 hits.
    InterProiIPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view]
    PANTHERiPTHR11073. PTHR11073. 1 hit.
    PfamiPF00262. Calreticulin. 1 hit.
    [Graphical view]
    PRINTSiPR00626. CALRETICULIN.
    SUPFAMiSSF49899. SSF49899. 2 hits.
    SSF63887. SSF63887. 1 hit.
    PROSITEiPS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SYT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFQGFWLCL GLLFISVNAE FMDDSVEMED FDENSEETDE LSSEIKYKTP    50
    QPVGEVYFTE TFDSGRLAGW VLSKAKKDDI DAEISIYDGR WEIEELKENR 100
    IPGDRGLVLK SRAKHHAISA VLAKPFIFAD KPLVVQYEVN FQDGIDCGGA 150
    YIKLLADTDG LNLENFYDKT SYTIMFGPDK CGEDYKLHFI FRHKHPKTGV 200
    FEEKHAKPPD VDLKRFFTDR KTHLYTLVMN PDDTFEVLID QIVVNKGSLL 250
    EDVVPPINPP KEIEDPTDEK PDDWDERAKI PDASAVKPED WDESEPPQIV 300
    DSSAVKPDGW LDNEPEFIPD PNAEKPFDWN EDMDGEWEAP HISNPACRIG 350
    CGEWSPPMID NPKYKGIWRP PMIDNPNYQG IWSPRKIPNP DYFEDNHPFL 400
    LTSFRALGLE LWSMTSDIYF DNFIICSEKE VADRWAADGW GMKILIENAN 450
    EPSIFKQLMS ATEQRPWLWF IYLLTAALPI ALIGSFCWPR KVKKKYEDVA 500
    FEKLDICKPQ TKGALEQEVK EEKAALEKPV DLEEEKKQSD GEIVEKEEEG 550
    EPEEKSEEEI EIIEGQEEGN KSNKSGSEDE MKEADESTGS GDGPIKSVRK 600
    RRVRKE 606
    Length:606
    Mass (Da):69,515
    Last modified:October 11, 2005 - v1
    Checksum:i4FAE7CE2EBF8EB4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103401 mRNA. Translation: AAI03402.1.
    RefSeqiNP_001029377.1. NM_001034205.2.
    UniGeneiBt.17314.

    Genome annotation databases

    EnsembliENSBTAT00000002071; ENSBTAP00000002071; ENSBTAG00000001580.
    GeneIDi504256.
    KEGGibta:504256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103401 mRNA. Translation: AAI03402.1 .
    RefSeqi NP_001029377.1. NM_001034205.2.
    UniGenei Bt.17314.

    3D structure databases

    ProteinModelPortali Q3SYT6.
    SMRi Q3SYT6. Positions 47-442.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q3SYT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002071 ; ENSBTAP00000002071 ; ENSBTAG00000001580 .
    GeneIDi 504256.
    KEGGi bta:504256.

    Organism-specific databases

    CTDi 1047.

    Phylogenomic databases

    eggNOGi NOG305105.
    GeneTreei ENSGT00430000030841.
    HOVERGENi HBG005407.
    InParanoidi Q3SYT6.
    KOi K09551.
    OMAi EEKHAKP.
    OrthoDBi EOG77126Z.
    TreeFami TF300618.

    Miscellaneous databases

    NextBioi 20866586.

    Family and domain databases

    Gene3Di 2.10.250.10. 1 hit.
    2.60.120.200. 2 hits.
    InterProi IPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view ]
    PANTHERi PTHR11073. PTHR11073. 1 hit.
    Pfami PF00262. Calreticulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00626. CALRETICULIN.
    SUPFAMi SSF49899. SSF49899. 2 hits.
    SSF63887. SSF63887. 1 hit.
    PROSITEi PS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiCLGN_BOVIN
    AccessioniPrimary (citable) accession number: Q3SYT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3