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Q3SYT6 (CLGN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calmegin
Gene names
Name:CLGN
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions By similarity.

Subunit structure

Interacts with PPIB and PDILT. Interacts with ADAM2 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the calreticulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 606587Calmegin
PRO_0000236245

Regions

Topological domain20 – 466447Lumenal Potential
Transmembrane467 – 48721Helical; Potential
Topological domain488 – 606119Cytoplasmic Potential
Repeat263 – 276141-1
Repeat280 – 293141-2
Repeat299 – 312141-3
Repeat318 – 331141-4
Repeat335 – 348142-1
Repeat352 – 365142-2
Repeat366 – 379142-3
Repeat380 – 393142-4
Region313 – 34634Interaction with PPIB By similarity

Amino acid modifications

Modified residue5561Phosphoserine By similarity
Modified residue5721Phosphoserine By similarity
Disulfide bond147 ↔ 181 By similarity
Disulfide bond347 ↔ 351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SYT6 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 4FAE7CE2EBF8EB4D

FASTA60669,515
        10         20         30         40         50         60 
MRFQGFWLCL GLLFISVNAE FMDDSVEMED FDENSEETDE LSSEIKYKTP QPVGEVYFTE 

        70         80         90        100        110        120 
TFDSGRLAGW VLSKAKKDDI DAEISIYDGR WEIEELKENR IPGDRGLVLK SRAKHHAISA 

       130        140        150        160        170        180 
VLAKPFIFAD KPLVVQYEVN FQDGIDCGGA YIKLLADTDG LNLENFYDKT SYTIMFGPDK 

       190        200        210        220        230        240 
CGEDYKLHFI FRHKHPKTGV FEEKHAKPPD VDLKRFFTDR KTHLYTLVMN PDDTFEVLID 

       250        260        270        280        290        300 
QIVVNKGSLL EDVVPPINPP KEIEDPTDEK PDDWDERAKI PDASAVKPED WDESEPPQIV 

       310        320        330        340        350        360 
DSSAVKPDGW LDNEPEFIPD PNAEKPFDWN EDMDGEWEAP HISNPACRIG CGEWSPPMID 

       370        380        390        400        410        420 
NPKYKGIWRP PMIDNPNYQG IWSPRKIPNP DYFEDNHPFL LTSFRALGLE LWSMTSDIYF 

       430        440        450        460        470        480 
DNFIICSEKE VADRWAADGW GMKILIENAN EPSIFKQLMS ATEQRPWLWF IYLLTAALPI 

       490        500        510        520        530        540 
ALIGSFCWPR KVKKKYEDVA FEKLDICKPQ TKGALEQEVK EEKAALEKPV DLEEEKKQSD 

       550        560        570        580        590        600 
GEIVEKEEEG EPEEKSEEEI EIIEGQEEGN KSNKSGSEDE MKEADESTGS GDGPIKSVRK 


RRVRKE 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC103401 mRNA. Translation: AAI03402.1.
RefSeqNP_001029377.1. NM_001034205.2.
UniGeneBt.17314.

3D structure databases

ProteinModelPortalQ3SYT6.
SMRQ3SYT6. Positions 47-442.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ3SYT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002071; ENSBTAP00000002071; ENSBTAG00000001580.
GeneID504256.
KEGGbta:504256.

Organism-specific databases

CTD1047.

Phylogenomic databases

eggNOGNOG305105.
GeneTreeENSGT00430000030841.
HOVERGENHBG005407.
InParanoidQ3SYT6.
KOK09551.
OMAEEKHAKP.
OrthoDBEOG77126Z.
TreeFamTF300618.

Family and domain databases

Gene3D2.10.250.10. 1 hit.
2.60.120.200. 2 hits.
InterProIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERPTHR11073. PTHR11073. 1 hit.
PfamPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSPR00626. CALRETICULIN.
SUPFAMSSF49899. SSF49899. 2 hits.
SSF63887. SSF63887. 1 hit.
PROSITEPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866586.

Entry information

Entry nameCLGN_BOVIN
AccessionPrimary (citable) accession number: Q3SYT6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families