Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable C->U-editing enzyme APOBEC-2

Gene

APOBEC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.By similarity

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalyticBy similarity1
Metal bindingi98Zinc; catalyticBy similarity1
Active sitei100Proton donorBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C->U-editing enzyme APOBEC-2 (EC:3.5.4.36)
Alternative name(s):
mRNA(cytosine(6666)) deaminase 2
Gene namesi
Name:APOBEC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444221 – 224Probable C->U-editing enzyme APOBEC-2Add BLAST224

Proteomic databases

PaxDbiQ3SYR3.
PRIDEiQ3SYR3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005974.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035907.

Structurei

3D structure databases

ProteinModelPortaliQ3SYR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 169CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX13. Eukaryota.
ENOG4111K4B. LUCA.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ3SYR3.
KOiK18772.
OMAiQSKAFEP.
OrthoDBiEOG091G0JNJ.
TreeFamiTF331356.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKEEAAAA AEPASQNGEE VENLEDPEKL KELIELPPFE IVTGERLPAH
60 70 80 90 100
YFKFQFRNVE YSSGRNKTFL CYVVEAQSKG GQVQASRGYL EDEHATNHAE
110 120 130 140 150
EAFFNSIMPT FDPALRYMVT WYVSSSPCAA CADRIVKTLN KTKNLRLLIL
160 170 180 190 200
VGRLFMWEEP EIQAALRKLK EAGCRLRIMK PQDFEYIWQN FVEQEEGESK
210 220
AFEPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,962
Last modified:October 11, 2005 - v1
Checksum:i54881038F34C504C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280381 mRNA. Translation: ABB90107.1.
BC103438 mRNA. Translation: AAI03439.1.
RefSeqiNP_001029527.1. NM_001034355.1.
UniGeneiBt.49125.

Genome annotation databases

EnsembliENSBTAT00000036043; ENSBTAP00000035907; ENSBTAG00000005974.
GeneIDi509619.
KEGGibta:509619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280381 mRNA. Translation: ABB90107.1.
BC103438 mRNA. Translation: AAI03439.1.
RefSeqiNP_001029527.1. NM_001034355.1.
UniGeneiBt.49125.

3D structure databases

ProteinModelPortaliQ3SYR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035907.

Proteomic databases

PaxDbiQ3SYR3.
PRIDEiQ3SYR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036043; ENSBTAP00000035907; ENSBTAG00000005974.
GeneIDi509619.
KEGGibta:509619.

Organism-specific databases

CTDi10930.

Phylogenomic databases

eggNOGiENOG410IX13. Eukaryota.
ENOG4111K4B. LUCA.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ3SYR3.
KOiK18772.
OMAiQSKAFEP.
OrthoDBiEOG091G0JNJ.
TreeFamiTF331356.

Gene expression databases

BgeeiENSBTAG00000005974.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABEC2_BOVIN
AccessioniPrimary (citable) accession number: Q3SYR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 11, 2005
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.