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Protein

Probable C->U-editing enzyme APOBEC-2

Gene

APOBEC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.By similarity

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalyticBy similarity1
Metal bindingi98Zinc; catalyticBy similarity1
Active sitei100Proton donorBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-72200 mRNA Editing: C to U Conversion
R-BTA-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C->U-editing enzyme APOBEC-2 (EC:3.5.4.36)
Alternative name(s):
mRNA(cytosine(6666)) deaminase 2
Gene namesi
Name:APOBEC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:26028 APOBEC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444221 – 224Probable C->U-editing enzyme APOBEC-2Add BLAST224

Proteomic databases

PaxDbiQ3SYR3
PRIDEiQ3SYR3

Expressioni

Gene expression databases

BgeeiENSBTAG00000005974

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035907

Structurei

3D structure databases

ProteinModelPortaliQ3SYR3
SMRiQ3SYR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 169CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IX13 Eukaryota
ENOG4111K4B LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033754
HOVERGENiHBG107155
InParanoidiQ3SYR3
KOiK18772
OMAiQSKAFEP
OrthoDBiEOG091G0JNJ
TreeFamiTF331356

Family and domain databases

InterProiView protein in InterPro
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKEEAAAA AEPASQNGEE VENLEDPEKL KELIELPPFE IVTGERLPAH
60 70 80 90 100
YFKFQFRNVE YSSGRNKTFL CYVVEAQSKG GQVQASRGYL EDEHATNHAE
110 120 130 140 150
EAFFNSIMPT FDPALRYMVT WYVSSSPCAA CADRIVKTLN KTKNLRLLIL
160 170 180 190 200
VGRLFMWEEP EIQAALRKLK EAGCRLRIMK PQDFEYIWQN FVEQEEGESK
210 220
AFEPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,962
Last modified:October 11, 2005 - v1
Checksum:i54881038F34C504C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280381 mRNA Translation: ABB90107.1
BC103438 mRNA Translation: AAI03439.1
RefSeqiNP_001029527.1, NM_001034355.1
UniGeneiBt.49125

Genome annotation databases

EnsembliENSBTAT00000036043; ENSBTAP00000035907; ENSBTAG00000005974
GeneIDi509619
KEGGibta:509619

Similar proteinsi

Entry informationi

Entry nameiABEC2_BOVIN
AccessioniPrimary (citable) accession number: Q3SYR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health