ID   CTRC_MOUSE              Reviewed;         268 AA.
AC   Q3SYP2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-MAR-2009, entry version 30.
DE   RecName: Full=Chymotrypsin-C;
DE            EC=3.4.21.2;
DE   Flags: Precursor;
GN   Name=Ctrc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has chymotrypsin-type protease activity and hypocalcemic
CC       activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa,
CC       Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Elastase
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC103715; AAI03716.1; -; mRNA.
DR   EMBL; BC115516; AAI15517.1; -; mRNA.
DR   EMBL; BC115517; AAI15518.1; -; mRNA.
DR   IPI; IPI00378682; -.
DR   RefSeq; NP_001029047.1; -.
DR   UniGene; Mm.440471; -.
DR   SMR; Q3SYP2; 17-268.
DR   MEROPS; S01.157; -.
DR   Ensembl; ENSMUSG00000062478; Mus musculus.
DR   GeneID; 76701; -.
DR   KEGG; mmu:76701; -.
DR   MGI; MGI:1923951; Ctrc.
DR   HOGENOM; Q3SYP2; -.
DR   HOVERGEN; Q3SYP2; -.
DR   BRENDA; 3.4.21.2; 244.
DR   NextBio; 345647; -.
DR   ArrayExpress; Q3SYP2; -.
DR   Bgee; Q3SYP2; -.
DR   CleanEx; MM_CTRC; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Protease; Serine protease;
KW   Signal; Zymogen.
FT   SIGNAL        1     16       Potential.
FT   PROPEP       17     29       Activation peptide (By similarity).
FT                                /FTId=PRO_0000288616.
FT   CHAIN        30    268       Chymotrypsin-C.
FT                                /FTId=PRO_0000288617.
FT   DOMAIN       30    267       Peptidase S1.
FT   ACT_SITE     74     74       Charge relay system (By similarity).
FT   ACT_SITE    121    121       Charge relay system (By similarity).
FT   ACT_SITE    216    216       Charge relay system (By similarity).
FT   CARBOHYD     25     25       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     79     79       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    182    182       N-linked (GlcNAc...) (Potential).
FT   DISULFID     17    141       By similarity.
FT   DISULFID     59     75       By similarity.
FT   DISULFID    155    222       By similarity.
FT   DISULFID    186    202       By similarity.
FT   DISULFID    212    243       By similarity.
SQ   SEQUENCE   268 AA;  29470 MW;  F5B813882E5F93C4 CRC64;
     MLGITVLAAI LACASSCGDP TFPPNLSARV VGGEDAVPNS WPWQVSLQYL RDDTWRHTCG
     GSLITTSHVL TAAHCINTNL TYRVGLGKYN LTVEDEEGSV YAEVDTIYVH EKWNRLLLWN
     DIAIIKLAEP VELSDTIQVA CIPEQDSLLP GDYPCYVTGW GRLWTNGPIA EVLQQGLQPI
     VNHTTCSRLD WWFIKVRETM VCAGGDGVIS ACNGDSGGPL NCPVEDGLWQ VHGIVSFGSS
     RGCNTYKKPV VFTRVSAYID WIKEKIQL
//