Q3SYP2 (CTRC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chymotrypsin-C
EC=3.4.21.2

Gene names

Name:

Ctrc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has chymotrypsin-type protease activity and hypocalcemic activity By similarity.
Catalytic activity	Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.
Sequence similarities	Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 29	13	Activation peptide By similarity		PRO_0000288616
	Chain	30 – 268	239	Chymotrypsin-C		PRO_0000288617
Regions
	Domain	30 – 267	238	Peptidase S1
Sites
	Active site	74	1	Charge relay system By similarity
	Active site	121	1	Charge relay system By similarity
	Active site	216	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Disulfide bond	17 ↔ 141		By similarity
	Disulfide bond	59 ↔ 75		By similarity
	Disulfide bond	155 ↔ 222		By similarity
	Disulfide bond	186 ↔ 202		By similarity
	Disulfide bond	212 ↔ 243		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SYP2 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: F5B813882E5F93C4	FASTA	268	29,470
	10 20 30 40 50 60 MLGITVLAAI LACASSCGDP TFPPNLSARV VGGEDAVPNS WPWQVSLQYL RDDTWRHTCG 70 80 90 100 110 120 GSLITTSHVL TAAHCINTNL TYRVGLGKYN LTVEDEEGSV YAEVDTIYVH EKWNRLLLWN 130 140 150 160 170 180 DIAIIKLAEP VELSDTIQVA CIPEQDSLLP GDYPCYVTGW GRLWTNGPIA EVLQQGLQPI 190 200 210 220 230 240 VNHTTCSRLD WWFIKVRETM VCAGGDGVIS ACNGDSGGPL NCPVEDGLWQ VHGIVSFGSS 250 260 RGCNTYKKPV VFTRVSAYID WIKEKIQL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC103715 mRNA. Translation: AAI03716.1. BC115516 mRNA. Translation: AAI15517.1. BC115517 mRNA. Translation: AAI15518.1.
IPI	IPI00378682.
RefSeq	NP_001029047.1. NM_001033875.2.
UniGene	Mm.440471.
3D structure databases
HSSP	HSSP built from PDB template 2D26 based on UniProtKB P00772.
ProteinModelPortal	Q3SYP2.
SMR	Q3SYP2. Positions 17-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SYP2.
Protein family/group databases
MEROPS	S01.157.
Proteomic databases
PRIDE	Q3SYP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	76701.
KEGG	mmu:76701.
UCSC	uc008vpk.1. mouse.
Organism-specific databases
CTD	11330.
MGI	MGI:1923951. Ctrc.
Phylogenomic databases
eggNOG	roNOG04592.
GeneTree	ENSGT00550000074117.
HOGENOM	HBG755338.
HOVERGEN	HBG013304.
InParanoid	Q3SYP2.
Gene expression databases
ArrayExpress	Q3SYP2.
Bgee	Q3SYP2.
CleanEx	MM_CTRC.
Genevestigator	Q3SYP2.
Family and domain databases
InterPro	IPR009003. Pept_cys/ser_Trypsin-like. IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
KO	K01311.
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	345647.
SOURCE	Search...

Entry information

Entry name

CTRC_MOUSE

Accession

Primary (citable) accession number: Q3SYP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program