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Protein

Chymotrypsin-C

Gene

Ctrc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has chymotrypsin-type protease activity and hypocalcemic activity.By similarity

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay systemBy similarity
Active sitei121 – 1211Charge relay systemBy similarity
Active sitei216 – 2161Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.157.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Gene namesi
Name:Ctrc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923951. Ctrc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 2913Activation peptideBy similarityPRO_0000288616Add
BLAST
Chaini30 – 268239Chymotrypsin-CPRO_0000288617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 141PROSITE-ProRule annotation
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ3SYP2.
PRIDEiQ3SYP2.

Expressioni

Gene expression databases

CleanExiMM_CTRC.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039879.

Structurei

3D structure databases

ProteinModelPortaliQ3SYP2.
SMRiQ3SYP2. Positions 30-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 267238Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ3SYP2.
KOiK01311.
PhylomeDBiQ3SYP2.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGITVLAAI LACASSCGDP TFPPNLSARV VGGEDAVPNS WPWQVSLQYL
60 70 80 90 100
RDDTWRHTCG GSLITTSHVL TAAHCINTNL TYRVGLGKYN LTVEDEEGSV
110 120 130 140 150
YAEVDTIYVH EKWNRLLLWN DIAIIKLAEP VELSDTIQVA CIPEQDSLLP
160 170 180 190 200
GDYPCYVTGW GRLWTNGPIA EVLQQGLQPI VNHTTCSRLD WWFIKVRETM
210 220 230 240 250
VCAGGDGVIS ACNGDSGGPL NCPVEDGLWQ VHGIVSFGSS RGCNTYKKPV
260
VFTRVSAYID WIKEKIQL
Length:268
Mass (Da):29,470
Last modified:October 11, 2005 - v1
Checksum:iF5B813882E5F93C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103715 mRNA. Translation: AAI03716.1.
BC115516 mRNA. Translation: AAI15517.1.
BC115517 mRNA. Translation: AAI15518.1.
RefSeqiNP_001029047.1. NM_001033875.2.
UniGeneiMm.489680.

Genome annotation databases

GeneIDi76701.
KEGGimmu:76701.
UCSCiuc008vpk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103715 mRNA. Translation: AAI03716.1.
BC115516 mRNA. Translation: AAI15517.1.
BC115517 mRNA. Translation: AAI15518.1.
RefSeqiNP_001029047.1. NM_001033875.2.
UniGeneiMm.489680.

3D structure databases

ProteinModelPortaliQ3SYP2.
SMRiQ3SYP2. Positions 30-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039879.

Protein family/group databases

MEROPSiS01.157.

Proteomic databases

PaxDbiQ3SYP2.
PRIDEiQ3SYP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76701.
KEGGimmu:76701.
UCSCiuc008vpk.1. mouse.

Organism-specific databases

CTDi11330.
MGIiMGI:1923951. Ctrc.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ3SYP2.
KOiK01311.
PhylomeDBiQ3SYP2.

Miscellaneous databases

ChiTaRSiCtrc. mouse.
PROiQ3SYP2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CTRC.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiCTRC_MOUSE
AccessioniPrimary (citable) accession number: Q3SYP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.