Reviewed, UniProtKB/Swiss-Prot Q3SYP2 (CTRC_MOUSE)

Names and origin

Protein names

Recommended name:
    Chymotrypsin-C
    EC=3.4.21.2

Gene names

Name:

Ctrc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has chymotrypsin-type protease activity and hypocalcemic activity By similarity.
Catalytic activity	Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.
Sequence similarities	Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 29	13	Activation peptide By similarity		PRO_0000288616
	Chain	30 – 268	239	Chymotrypsin-C		PRO_0000288617
Regions
	Domain	30 – 267	238	Peptidase S1
Sites
	Active site	74	1	Charge relay system By similarity
	Active site	121	1	Charge relay system By similarity
	Active site	216	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Disulfide bond	17 ↔ 141		By similarity
	Disulfide bond	59 ↔ 75		By similarity
	Disulfide bond	155 ↔ 222		By similarity
	Disulfide bond	186 ↔ 202		By similarity
	Disulfide bond	212 ↔ 243		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SYP2-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: F5B813882E5F93C4	FASTA	268	29,470
	10 20 30 40 50 60 MLGITVLAAI LACASSCGDP TFPPNLSARV VGGEDAVPNS WPWQVSLQYL RDDTWRHTCG 70 80 90 100 110 120 GSLITTSHVL TAAHCINTNL TYRVGLGKYN LTVEDEEGSV YAEVDTIYVH EKWNRLLLWN 130 140 150 160 170 180 DIAIIKLAEP VELSDTIQVA CIPEQDSLLP GDYPCYVTGW GRLWTNGPIA EVLQQGLQPI 190 200 210 220 230 240 VNHTTCSRLD WWFIKVRETM VCAGGDGVIS ACNGDSGGPL NCPVEDGLWQ VHGIVSFGSS 250 260 RGCNTYKKPV VFTRVSAYID WIKEKIQL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC103715 mRNA. Translation: AAI03716.1. BC115516 mRNA. Translation: AAI15517.1. BC115517 mRNA. Translation: AAI15518.1.
IPI	IPI00378682.
RefSeq	NP_001029047.1.
UniGene	Mm.440471
3D structure databases
SMR	Q3SYP2. Positions 17-268.
ModBase	Search...
Protein family/group databases
MEROPS	S01.157.
Genome annotation databases
Ensembl	ENSMUSG00000062478. Mus musculus. [Contig view]
GeneID	76701.
KEGG	mmu:76701.
Organism-specific databases
MGI	MGI:1923951. Ctrc.
Phylogenomic databases
HOGENOM	Q3SYP2.
HOVERGEN	Q3SYP2.
Enzyme and pathway databases
BRENDA	3.4.21.2. 244.
Gene expression databases
ArrayExpress	Q3SYP2.
Bgee	Q3SYP2.
CleanEx	MM_CTRC.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	345647.
SOURCE	Search...

Entry information

Entry name

CTRC_MOUSE

Accession

Primary (citable) accession number: Q3SYP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2005
Last modified:	March 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)